Peptides gaaban iyo polypeptides oo qayb ka ah nafaqada isboortiga. Maxaa si ay u doortaan?

Peptides waa hab caan ah oo loo isticmaalo in nidaamka ee diyaarinta nafaqada isboortiga ee ciyaaraha fudud ee hiwaayadda iyo xirfad cayaareed [3]. All peptides - sports ka kooban nafaqo - waxa loo qaybin karaa 2 kooxood: gaaban (yar) peptides iyo polypeptides ( "weyn"). peptides The ka kooban yihiin qaybaha fudud - acids amino. Haddii peptide ay ku jiraan tiro yar oo acids amino, tusaale ahaan 3 ama 4, - waa peptide gaaban. Haddii peptide waa 20-30 acids amino, iyo qaar kaloo badan - waa polypeptide ah. Polypeptides - this ku dhowaad waa isku mid sida in ka mid ah borotiinka - taagoo muhiimka ah ee jirka. Maxay muhiim u tahay horyaalka galay peptides gaaban iyo polypeptides? From dhererka peptide waxay ku xiran tahay in ay shaqada, hufnaanta iyo ammaanka marka loo isticmaalo in nafaqo isboortiga.

Currently caan u sidii cayaareed ah qaybaha nafaqada waa polypeptides kor u gubashadii baruurta, kordhin mass muruqa, la kordhiyo difaaca jirka, wanaajiyo caafimaadka guud ahaan. Si kastaba ha ahaatee, waxay leedahay cillado muhiim ah. Polypeptides, gaar ahaan hoormoonka peptide, waxaa laga yaabaa in aynan kasta oo kale, uu carqaladeeyo hormoonnada dabiiciga ah ee jirka ku jira. Intaa waxaa dheer, ee peptides oo dhan "weyn" waa shisheeye jidhka oo sababi kara dareen diidmo oo xasaasiyadeed. dhaqdhaqaaqa jirka High in si joogto ah oo tijaabo u Orodyahanka, inta badan gacan ka hoos u dhac in difaac, taas oo sii kordhiyaa dhinaca dareen diidmo oo xasaasiyadeed ka isticmaalaya polypeptides ah. Maxaa yeelay, polypeptides waxaa inta badan go'doonsan ka shaqeeyo xoolaha [2, 3, 9], jebiso nadiifinta technology iyaga oo ku nijaasta waxyeelada waxaa laga yaabaa in la joogo - borotiinada shisheeye, Goosimo DNA, fayrasyada, prions, kaas oo sidoo kale hantidaan immunogenicity (awoodda si ay u abaari xasaasiyadda) iyo waxay keeni kartaa in horumarka cudurada.

waxaa suurtagal ah in sidaas la sameeyo, si ay u sii guryaha waxtar leh ee polypeptides bioregulatory iyo waqti isku mid ah in meesha laga saaro qaladaad ay? Haa, hadda waxa uu noqday suurtagal ah. Sidaas darteed of sano cilmi, waxaa la ogaaday in polypeptide kasta waa xarunta firfircoon - in qayb yar oo ka mid ah, kaas oo masuul ka ah shaqo ee peptide ah. Ku salaysan falanqaynta ee halabuurka ah ee polypeptides sida ay technology gaar saxda Pharma GmbH peptides gaaban ayaa laga abuuray, oo ka kooban 2, 3 ama 4 harta amino acid [5, 6, 7]. peptides noocan oo kale ah oo gaaban oo aan lagama maarmaan ah in laga unugyada xayawaanka jaraan, oo waxay kiimikaad la samaysan karin. Waa ammaan, maxaa yeelay, peptides dardaro ma ku jiraan waxyaabaha keeni xasaasiyad. Sayidka peptides gaaban IPH on dhismeedka gabi ahaanba isku si dabiici ah oo firfircoon (functional) polypeptide xarumaha taagoo oo aan gartay by jidhka sida walxaha shisheeye. Waxaa muhiim ah in la ogaado in peptides gaaban IPH, isagoo muhiimad "shaqo" ee Britain polypeptide loo isticmaalo ee nafaqada ciyaaraha heer ka hooseeya ee "peptides weyn."

Faa'iidada kale muhiim ah oo IPH peptides gaaban waa awoodda ay u leeyihiin waxaa ka wanaagsan ee jidhku u nuugo marka la barbar dhigo polypeptides ah. Sidee tani u dhici? Borotiin iyo polypeptides jidhka galaan cunto, galaan caloosha iyo xiidmaha. peptides gaaban oo ka kooban 2 ama 3 harta amino acid - Waxaa ay la kaashanayo of falgalka gaar ah (peptidases) "gooyaa" Goosimo yar yihiin. Markaas peptides gaaban galaan dhiigga iyo gaadiid si muruqyada iyo xubnaha kale iyo unugyada, kaas oo ay leeyihiin saamayn sharciyeed. Inta badan oo ka mid ah polypeptides, taas oo aan ka helno sida qayb ka mid ah nafaqada sports noqon doonaa "gooyaa" peptidase oo aan lahayn saamayn la doonayo, ama saamaynta ay noqon doontaa taagta daran. In this peptides gaaban IPH qayb ka mid ah nafaqada isboortiga waa doono isla markiiba ka caloosha iyo mindhicirrada gala dhiigga iyo unugyada, aan jabiyay. Currently saxda Pharma GmbH loogu talagalay oo ku dhexsameeysmo taxane ah oo peptides gaaban, loo yaqaan IPH, waayo, wershedaha dawooyinka, cuntada, la isku qurxiyo iyo isboortiga, kuwaas oo kicin difaaca jirka, nidaamka neerfaha iyo hormoonada jidhka, leeyihiin guryaha antioxidant, dhaqaajiso-shiid iyo u adeega ka hortaga kansarka iyo kor u socdeyba [5, 6, 7, 8]. Waa in la ogaadaa in polypeptides aan had iyo jeer la ogaado hab saxda ah ee dhaqdhaqaaqa noolaha, halka for peptides gaaban IPH waxbarashada noocan oo kale ah inta badan ka sahlan qaban oo aan ilaa hiddo loo raad raaco karo hab ay tallaabo peptide dhan [1, 5, 6, 7, 8, 10 ]. Tani waxay u ogolaaneysaa in aad si kalsooni leh u diyaariso ee waxtarka iyo nabadgelyada peptides gaaban IPH soo saaray saxda Pharma GmbH (Germany).

Sayidka, ka peptides gaaban IPH, isagoo dhammaan saamaynta noolaha ee polypeptides, ammaan ah, non-immunogenic, waxay leeyihiin hab sayniska ku salaysan ficilka iyo waa xalka ugu wanaagsan sida a qaybaha nafaqada isboortiga [4] iyo dulinka ah ee horumarinta Farmashiiste casriga ah iyo daawada kelli.

Ilo xaqiijiyo waxtarka iyo nabadgelyada peptides gaaban

1. Ashapkin aayadaha, Linkov NS, Havinson VH, Vanyushin BF hababka Epigenetic xeerka peptidergic ah ee ra'yi dhiibashada hiddo-ee gaboobaya unugyada aadanaha // Kiimikada noole. - 2015. - V. 80, Issue. 3. - P. 374-388.
2. Zilov WAA qaybaha Protein cuntooyinka gaarka ah ee Isboorti ee // Nafaqada. - 2014 - T.83, №53. - C. 133.
3. Mezenova NY, vertuhaya aayadaha, Volkov aayadaha, Baydalinova LIS Mezenova OJ Determination of xuduudaheedu farsamada ee budo ah peptides firfircoon ka qolfo kalluunka oo qayb ka ah wax soo saarka bio-si nafaqada isboortiga // Talaaboda Guri ka mid ah jaamacadaha. Applied Chemistry iyo bayotechnoolajiyadda. - 2016 - №2 (17). - S. 104-114.
4. Havinson VH, Trofimova SV, Trofimov AV, Kachan ey, Wiener Usmanov IA Terekhina RN, Kryuchek ES, EA Pyrozhkov Hababka ku salaysan kordhinta heerka diyaarinta gymnasts heer sare isticmaalaan tababarka iyo peptide bioregulators jirka gaar ah. // Tilmaamaha. - St. Petersburg: St. Petersburg Bio-sharciyeynta iyo Institute Gerontology.. - 2013. - 44 p.
5. Khavinson V.Kh., Polyakova vo, Linkova NS, Dudkov AV, Kvetnoy IM Peptides Sharciyeyn Cortical Thymocytes kaladuwan, Faafidda qoryaha, iyo Apoptosis // Journal of Amino acids. 2011. ArticleID 517137. P. 1-5.
6. Khavinson V.Kh., Tendler SM, Rfsyanenko NA, Tarnovskaya SI, Linkova NS, Ashapkin aayadaha, Yakutseni PP, Vanyushin BF Tetrapeptide KEDW macaamila DNA oo dejisa Gene Expression // American Journal of Biomedical Sciences. - 2015. - Vol. 7, N3. - P. 156-169. Khavinson V.Kh., Tendler SM, Vanyushin BF, Kasyanenko NA, Kvetnoy IM, Linkovan.S., Ashapkin aayadaha, Polyakova vo, Basharina VS, Bernaotte A. Peptide Regulation of Expression Gene iyo Avv Protein ee bronki epithelium // sambabada. - 2014 - Vol. 192. - P. 781-791.
7. Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV peptide The semax saamayn ku muujinta hiddo-xiriira nidaamka difaaca jirka iyo maskaxda vascular rat ischemia focal: hiddawadayaasha oo dhan falanqaynta transcriptional // BMC Genomics . - 2014 - Vol. 15. - P. 228.
8. Stadnik J., P. Kęska Hilibka iyo hilibka si cajiib leh sida il of peptides bioactive // ActaSci Pol .Technol. Aliment. - 2015. - Vol. 14, N 3. - P. 181-190.
9. Sweetwyne MT, Pippin JW, Eng Wasarada, Hudkins KL, Chiao Ya, Campbell MD, Marcinek DJ, Alpers CE, Szeto HH, Rabinovitch PS, Shankland SJ peptide mitochondrial-beegsaday The, SS-31, hagaajinaysaa naqshadaha glomerular in jiirka ah ee da 'wayni // Int Keli. 2017 S0085-2538 (16) 30652-4.