Inhibitors proton pump: hab garoomada iyo codsiga in daawo

By inhibitors bamka proton waa koox ka mid ah wakiilada pharmacological in la yareeyo heerka of dheecaan of aashito ee caloosha. Saamayn toos ah ku ah canaliculi secretory, waxay ku ool ah u horseedi in ay boogaha la doonayo daweynta saamayn, gastritis erosive, GERD. Kooxda ayaa ka mid ah hannaanka ka mid ah daroogada ee qaab-dhismeedka kiimikada la mid ah, laakiin xuduudaheedu pharmacodynamic kala duwan, i.e. ficil ahaan daawooyinka la mid ah u dhaqmaan on unugyada secretory, laakiin sidaas la sameeyo in meelo badan iyo xawaare kala duwan.

inhibitors proton pump: dhinacyo kelli diyaarinta saamaynta

proton pump waa qaab-dhismeedka protein lays maamul adag oo ka mid ah udhigo hydrogen in Lumen ku gastric. Waxay ka kooban tahay laba cunsur kiimikaad duwana, haddii kale loo yaqaan subunits. Ta hore waxa weeye si gaar ah oo borotiin ah iyo waxaa la dhisay ka acids amino. In stuffer xuub gacanta u dhaqmo si gaar ah, u gudbaya 10 jeer, taas oo horseedaysa formation of siddo channel 5-secretory. Isagoo maraya saabka of udhigo dhaco Lumen gastric gudaha iyo siiyaan acidification ee dhexdhexaad ah iyo hoos u index hydrogen. Xaaladdan oo kale, waa in mid ka mid ah oo siddooyinkuna waa xarunta firfircoon ee borotiin ah - isku xigxiga oo ka mid ah 800 oo acids amino, oo catalyzes burburka ee ATP, substrate ugu weyn ee gacanta tamarta.

subunit kale waa adag protein ah in ka kooban yahay isku xigxiga polypeptide ah, siday u kala horreeyaan dhisme ku amray qaarkood iyo silsilado glycoprotein. Qaybta baaxad weyn oo Britain waa ka baxsan cytoplasm ah, iyo qayb ka mid ah glycoprotein malaha waa adag receptor ekstratsitoplazmaticheskim in diiro signal ee hawshooda u ah ee eulayska H + \ K + -ATPase. Xaaladdan oo qayb protein ah ee Britain ay u soo gudbo xuubka mar, soo jeedinaya miraheeda sida element Xiriirisa dibadda iyo receptor subunit ugu horeysay ee masuul ka ah qabashada cadaanyo horseed ee Avv protons.

Iyadoo la raacayo, qaab-dhismeedka bamka proton ku tubules secretory unugyada parietal soo gunaanadi karo, sida hab fudud ku xakamayn kartaa dheecaan ah ee H + galay saabka jidhka. Ku haysta muuqashadii ugu xaq - waa Iscelin of enzyme mas'uulka ka ah ereygu wuxuu ka dhigi inhibitors bamka proton.

Isticmaalka inhibitors in bukaan eegida

In daawada, inhibitors bamka proton hubkaas ayaa loo isticmaalaa, gaar ahaan gastroenterology, kaas oo la xidhiidha awoodda ay u leeyihiin in la yareeyo ashitada ee gastric dheecaan, iyo sidaas loo yareeyo xoogga saamaynta waxyeello on derbiga caloosha, kaas oo si gaar ah muhiim marka lagu kacsada. Xaaladdan oo kale saamaynta ay ku daweyn madax bannaan yahay etiology ee geedi socodka bararka, sida laga saaro by saameynta ay dagaal badan ee deegaanka ee daacadnimada ee jirka. Sidoo kale spectrum ee heley oo daaweyn loo isticmaalo wax ku ool ah proton inhibitors bamka ayaa la ballaariyay by boog gastric iyo boog dyspepsia, erosive iyo foomamka GERD non-erosive.

Waxaa ka mid ah daawooyinka ugu caansan waxaa ka mid ah inhibitors proton bamka la socda magacyo generic omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole, iyo kuwa kale. ka mid ah magacyada ganacsiga u istaagaan soo baxay, sida "Omez". Daawooyinka waxaa laga heli karaa foomka kaabsal. Waxaa loo qaataa afka ee qiyaasta qoray ee takhasuska ah, taas oo kala duwan iyada oo ku xidhan nooca gaarka ah ee cudurka. Iyada oo u ogolaanaya is-maamulka, maadaama ay jirto koox ka mid ah bukaanka ka cabanaya sii daridda xilliyeed ee boogaha gastric ama dyspepsia chronic. Xaaladaha kale, soo dhaweynta waxaa ay wadahadal la gashey dhakhtarka waqtiga gelitaanka.