Calaamadeysanayaan buro CA 19-9. Falanqaynta CA 19-9: caadi iyo markii uu ka soo sara kiciyey

calaamadeysanayaan buro CA 19-9 waa miisaanka kelli glycoprotein sare. Waxaa la soo saaray unugyada epithelium ee nidaamka dheefshiidka. Sida falanqayn immunohemilyuminestsentny habka cilmi isticmaalo. CA 19-9 waxa uu la xidhiidhaa heley kansarka.

warbixin guud

Si aad u barato wax ku noolaha sida loo isticmaalo dhiig arooriyaha. CA 19-9 - an calaamadeysanayaan burada wax ku ool ah. Its qeexidda waxaa loo isticmaalaa in cudurka, la socodka iyo goor hore la ogaado metastasis caloosha, xameetida, beerka, xiidmaha (colon iyo malawadka) ah. CA 19-9 heerarka kordhay ku dhowaad dhammaan bukaanka qaba burooyinka mindhicirka, gaar ahaan ganaca. Soo saaridda unugyada in burooyinka, glycoprotein guskiisa galay wareegga systemic. Kuurgalo iyo qiimaynta content, khubaro ku leeyihiin fursad ay ku raaci koorsada cudurka. Falanqaynta CA19-9, heerka of taas oo qof caafimaad qaba aan ka badnayn 10 U / ml looma isticmaalo in cudurka hoose.

Waa maxay kansarka ganaca? oo kooban

Cudurkaan oncological taariikhda ku jira liiska ku heley ugu khatarta badan. About 90% bukaanada dhiman sannaddii kowaad oo cudurka gudahood. Waqtiga ogaanshaha in 80% bukaannada helay metastases fog ama gobolka. Khubarada this yeelaan inta badan la qarsoon badan cudurada ka. Cudurku wuxuu inta badan qaatay, sida hababka chronic bararka aaga socodka xubnaha hepatopancreatoduodenal (cholelithiasis, cholecystitis, pankreatit chronic). In xidhiidh la leh baahida loo qabo this sida ugu dhaqsaha badan si ay u fuliyaan cudurka kala duwan ah, marka laga reebo jiritaanka kansar. Tani, markeeda, dooro doonaa istaraatijiyad ugu waxtarka badan daweynta ka mid ah xaaladaha raaga.

Antigen CA 19-9. fiirsashada

In kansarka ganaca waxaa jira heer sare ah glycoprotein. Falanqaynta CA19-9, taas oo ka kooban sharci ee kor ku xusan, waxay u baahan tahay ogaanshaha ee carcinoma, qiimaynta macquul ah resection. At-fiirsashada ah oo ka badan 1000 U neoplasm / ml arko buuxsan,% bukaannada kaliya 5. Haddii content uu yahay mid hoos ku qoran tirooyinka tilmaamay, burada sida caadiga ah waxa loo saari karaa. Si kastaba ha ahaatee, ka dib markii ay fara gelin ah mudo hal ilaa toddoba bilood, waxaa jira halis ah oo soo noq. calaamadeysanayaan buro CA 19-9 waa kii labaad ee muhiimadda ay leedahay ka dib markii EW calaamadeysanayaan loogu ogaado kansar caloosha ah. Intaa waxaa dheer, waxbarasho dheeraad ah oo miisaankiisu sare kelli glycoprotein xilsaaray Alfa-fetoprotein ee ogaanshaha iyo la socodka daaweynta kansarka beerka, mareenka biliary iyo kaadi haysta.

siyaadiyaa

Heerarka sare ee glycoprotein ah oo laga dheehan karo ku saabsan asalka ah heley kala duwan bararka iyo benign ee beerka iyo habdhiska dheefshiidka (ilaa 500, laakiin sida caadiga ah 100 U / ml), iyo cystic fibrosis. Xaaladda hore fiirsashada waxaa kordhay 12% bukaannada. Heerka ugu badan ee this - wax ka badan 45 U / ml. Glycoprotein raaca in bile ah. Marka tan la eego, cholestasis kasta oo ay wehlin karaan in la kordhiyo ay ka kooban tahay. Xaaladaha noocaas ah waxaa lagama maarmaan ah si ay u qabtaan cilmi-isku mar GGT (gamma-glutamattransferazy) iyo phosphatase xumadoodu. fiirsashada la kordhiyo sidoo kale lagu ogaan karaa on asalka ah ee burooyin kale Deegaamaynta (in kansarka mindhicirka, kansarka ugxan sidaha), cudurka beerka (cirrhosis, hepatitis).

Maqnaanshaha ama heer la dhimay

Khubarada ayaa sheegay in fiirsashada caadiga ah kama saarayso joogitaanka kansarka ganaca. Xaaladdan oo kale, waxaa lagu ogaan karaa cudurka marxalad hore marka heerka ayaa weli ma lahaa waqti ay ku kici. Daraasaddu waxay ku bukaanlayda qaadato daawada, hoos content ee glycoprotein waxay muujinayaan karaan waxtarka ah ee waxqabadyada-daweynta.

Taas oo u baahan cilmi

imtixaanka ee calaamadeysanayaan buro CA 19-9 waxaa loo baahan yahay in lala socdo wax ku oolnimada waxqabadyada-daweynta kansarka ganaca, iyo sidoo kale goor hore la ogaado cudurka ku xoogeystay. Baadhitaanka ayaa u ogolaanaya cudurka kala duwan ee kansar cudurro kale (tus, pankreatit) a. Tusiyaha CA 19-9 muujinaysaa baahsanaanta habka malignant, joogitaanka kansarka ee asalka ah metastases fog cudurka.

Xaaladaha qaarkood, daraasadda loo xilsaaray

imtixaanka ee calaamadeysanayaan buro CA 19-9 waxaa lagu talinayaa in muujinta calaamadaha kansarka ganaca: lallabo, xanuun caloosha, cagaarshow, miisaan lumis ah. Marmar loo xilsaaray bukaanka baadhitaan la-fiirsashada ah markii hore sare ee glycoprotein iyo daaweyn. Falanqaynta lagu talinayaa in looga shakisan yahay cudurka kansarka ee xameetida ama marinka biliary, beerka, caloosha ama mindhicirka. Research sidaas maamula isku dhafan oo baaritaano kale.

qoraalka

qiimaha tixraaca kala duwan kuwaas oo waa in ay ahaadaan heerka antigen - 0-35 U / ml. Sida aynu hore u kor ku xusan, fiirsashada sare ee glycoprotein muujinaysaa joogitaanka kansar ee beeryarada. The content sare, cudurka stage badan oo horumarsan. heer xad-dhaaf ah ayaa tilmaamaya metastasis buro.

macluumaad muhiim ah

content Test tixgeliyo glycoprotein si gaar ah muhiim in la ogaado hore ee faafitaanka xadka- kansarka ee beeryarada. About 7-10% dadka aan haysan hiddo in ey miisaanka kelli glycoprotein sare. Iyadoo la raacayo, ee jirka ku jirto awoodda ah hidde in synthesize antigen ee CA 19-9. Sidaas darteed, xitaa in cudurka heerka kansar ah glycoprotein waa lama dareemo ee serum ah.

Wixii macluumaad dheeraad ah,

Ka hor inta aadan dhiig ku deeqaan, khubaro ku talinaynaa in aan sigaar nus-saac. Qiimaha lagu ogaanayo baaritaanka uu kordho, halka daraasadda on EW. Waxa intaa dheer in dejinta cudurka ugu sax ah iyo daaweynta loo baahan yahay ballan ku habboon baaritaano lagula talinayaa CA 72-4, wadarta bilirubin, CA 242. waxbarashada Laboratory magacaabi khubarada sida hepatologist, sugan, dhakhtar qalliin ama Oncologist.

gunaanad

Khubarada la soco in kansarka maanta ee beeryarada waa sii kordhaysa caadi ah in bukaan 30 sano ka dib. cudurada Tani waa mid aad u liidata ogaado oo liidata kasteba si therapy. Marka tan la eego, imtixaanada ugu xasaasi ah ayaa loo baahan yahay in iyada la aqoonsado. Nasiib darro, daraasadda of fiirsashada antigen ma loo isticmaali karaa cudurka hore ee wareega cudurka. Si kastaba ha ahaatee, baaritaankaan waa ugu xasaasi ah oo xog badan ee lagu qiimeeyo waxtarka daawaynta, ogaanshaha marxaladaha hore ee metastasis kansarka. Waxaa sugan in, ku takhasusay baadhitaanka isticmaalaa natiijada hababka ogaanshaha kala duwan. Waxa intaa dheer in shaybaarka, bukaanka waxaa loo doortay iyo baaritaan xarkaha. Waxaa ugu heli karo oo ka mid ah hadda waa Maraykanka. In qabashada uu xirfad tilmaami karaa size buro ka soo laba sentimitir. Si loo caddeeyo size, booska, iyo faafinta kansar qori CT scan a. Isticmaalka habkan, waxaa lagu ogaan karaa ka size buro saddex sentimitir. Waa in la sheegay in dhaqanka CT ku xiran yahay in ay soo saaraan qiyaas qaar ka mid ah X-rays. Sidaa darteed, daraasaddan aan la sameeyaa si joogto ah ama sida prophylaxis. stress ka yar jirka bukaanka bixisaa MRI ah. Laakiin noocan oo kale ah cilmi looma fuliyo dadka qabto wax implants biraha. Dhammaan oo ka mid ah tallaabooyin lagu ogaanayo, oo ay la socdaan baaritaano dhiig lagu ogaan karaa marxaladaha hore ee horumarinta kansarka ama metastasis ee beeryarada.