"Theophylline": tilmaamaha loo isticmaalo. "Theophylline": muujinaya in loo isticmaalo ee analogues

Haddii qof xanuunka xirmidda marin-haweed, tan waxay muujin kartaa joogitaanka chronic obstructive pulmonary disease (COPD). Cudurkani waa caadi. Inta badan dhacdo ee cudurkan arkay in dadka sigaarka cabba. Horumarinta ee cudurkan waxaa sababa hit cudurka, ama waxa qaar ka mid ah dhaawac sambabada. Qofka qaba Cidhiidh marinka hawada si dhib leh neefta siidaysid karin. Sidaas darteed, calaamadaha ugu muhiimsan waa daliilka dyspnea cudurka, qufac, iyo wax soo saarka xaako ah. Waxaa muhiim ah in la ogaado. The ugu caansan waa horumarinta noocyo ka mid ah COPD. Tani waxay dhacdo neefta, boronkiitada chronic, emphysema, bronchiectasis. In daaweynta oo ka mid ah iyo dad badan oo cudurro kale oo kaa caawin doona daroogada sida "Theophylline" sida. Tilmaamaha loogu isticmaalo daroogada lagu dabooli doonaa ee qoraalkan ku xusan. Faahfaahin dheeraad ah oo arrintan ku saabsan.

description

"Theophylline", kuwaas oo ka kooban in la hoos lagu qeexay doonaa, waa budo crystalline cad. Waa wax yar L. biyo qabow (in saamiga 1: 180), laakiin waxaa si fudud u kala diri biyo kulul (in cabirku yahay 1:85). Waxa kale oo ay u kala diray in alkalis iyo acids.

Qaab-dhismeedka

In dejinta this qayb weyn ee firfircoon yahay theophylline. halkan sidoo kale ka mid ah qaybaha kaabayaal ah qaarkood. Oo kuwaasu - laktosmonohydrat lactose, milmahayn magnesium, Rusheyn kartaa, methacrylic acid.

Form sii daayo

Waxaa jira noocyada dhowr ah oo arrintan la xiriira. "Theophylline" macmalay sida kiniinno sii daayo-gaaray (0.1 g, 0,25 g), kaabsoosha (0.125 g, 0.5 g), oo dabada (0.2 g).

falalka pharmacological

Ka shaqeynayaan of dejinta yiri waa kala weji duwan. "Theophylline", dib u eegista ah kuwaas oo wanaagsan, nasashada Jimicsiyada muruqyada bronkie, ayaa tallaabo dhiirrigelin iyo vasodilator ah. diyaarinta Tani waxay xaqiijineysaa in hawlgalka caadiga ah ee xarunta neef mareenka. Baabi'iyo xanuun diaphragm iyo hagaajiyo hawlaha ay muruqyada intercostal sidoo kale ku kordhinaya "Theophylline". Its isticmaalo habka caadiga ah oo yareysa fursadda ah muujinta dareen diidmo oo xasaasiyadeed ee meydadka nooca neefsashada. Ayaa sheegay in diyaarinta ku isticmaali kartaa saamayn lagu durayo. Joogitaanka walxaha firfircoon oo medicament ee kor u caadi ah ee shaqo-mareenka, yaraynta heerka carbon dioxide iyo hawo kordhay. "Theophylline" ku ool ah u kordhiyaa wareegga wadnaha. waxay kaloo ka caawisaa si loo yareeyo midab ah ee weelasha maskaxda, kelyaha iyo wadnaha. Marka fulinta daaweynta dheer ayaa waxaa loo kordhiyay mareenka biliary, microcirculation caadi iyo iska caabin erythrocyte in lahayo ku kordhay. In dadka buka ka hypotension, waxaa laga yaabaa in hoos u cadaadiska dhiigga. Hirgelinta qaata diyaarinta noocan oo kale ah sida "theophylline", oo ay la socdaan beta-blockers, iyo antibiotics keenaysaa in halis kordhaysa oo ah waxyeelo.

Tilmaamayaasha

Ka dhig sheegay daroogada at dhacdo ee bronki neef, neef status, boronkiitada obstructive, emphysema pulmonary. Sidoo kale waxaa loo isticmaalaa sida gargaar ah carruurta dhasha la xibin gal. Isticmaal "Theophylline" ugu horrayn sida bronchodilator ah. Sidoo kale, waxay u isticmaal sida cardiotonic dhexdhexaad ah (kordhiyaa xoogga foosha wadnaha) iyo durayo (durayo) daroogada daliilka gabsiiya asal ahaan kelyaha iyo wadnaha. Mararka qaarkood waxaa si wadajir ah waxaa maamula la bararka kale oo bronchodilators.

sharaxaad faahfaahsan oo spectrum ee samaynta yiri

Marka hore, ee daaweynta ee COPD waa bronchodilators shaqo. Waxay qaadi siidaynta hawo-mareenka. Mid ka mid ah daawooyinkan, sidii horeba kor ku xusan, diyaarinta sida waa sida "theophylline". Tilmaamaha loogu isticmaalo waxa lagu tilmaamay sida daroogada bronchodilator ah, taas oo fulisa ku furid waxa loogu yeero ee receptors purine. Joogitaanka sida farsamo saameyn ay hubisaa in ka kaxayntu ay of dubaaxin ee muruqa siman of bronkie, tirtiridda xanuun diaphragm ka, dardargelinta Ogsijiinta oo sambabada, hagaajinta shaqada ee muruqyada intercostal. Sidaas darteed, hawo furo, qofka si fudud u neefsato.

Waxa faa'iido ah oo la hubo, "Theophylline". Tilmaamaha loogu isticmaalo daroogada waxay muujinaysaa in this wanaagsan saameyn ku yeelan kara ma aha oo kaliya on mareenka-mareenka, laakiin sidoo kale on nidaamyada kale ee jirka. daroogada Tani waxay ka caawisaa in ay ballaariso ku xididdada dhiigga wadnaha iyo durugsan, joogsaneyso habka of Amda dhiig xinjirowga, waa tallaabo fudud lagu durayo. Waxay bixisaa hawl manjooyin kicinta ee muruqa wadnaha (myocardium), cadaadis dhiig oo hooseeya, iyo sidoo kale saamayn faa'iido on habka dhexe ee neerfayaasha. Sidaas darteed, daroogada waa inay awoodaan inay u dhaqmaan oo isu, mar isagoo antiasthmatic, bronchodilator, durayo, spasmolytic, vasodilatory iyo guryaha cardiotonic.

"Theophylline": tilmaamaha loo isticmaalo

Si loo go'aamiyo qiyaasta, waxaa jira shuruudo badan. "Theophylline", sida ay tilmaanta, aad u baahan tahay in ay carruurta ku qabsan 14 jir iyo dadka waaweyn, 300 mg maalin kasta 2-3 jeer. Xaaladdan oo kale, daawada waa in biyo ka cabbaan ee u tiro badan. Haddii loo baahdo, ee qiyaasta waa la kordhin karaa in 500 mg 2 jeer maalintii, haddii uu takhtarku ku talinayaa. Haddii bukaanku leeyahay miisaanka jidhka ka yar 60 kg, qiyaasta waa in ay ahaataa 100 mg 2 jeer maalintii. Xaaladdan oo kale, soo dhaweynta loo magacaabay subaxda iyo fiidka of diyaarinta this sida "Theophylline". Waxbarashada dhigayaa in daawo loo baahan yahay si ay u bilaabaan la qiyaaso yar oo si tartiib ah iyaga ku sii badin in ay. daroogada waa in la sameeyaa xilliyada caadiga ah. Waa in ay noqon 2-3 maalmood. Sida laga soo xigtay waxbarashada, haddii habka daaweynta loo baahan yahay si ay u qabtaan nidaamka lagu ogaanayo joogto ah. Oo kuwaasu - fulinta falanqaynta dhiig, cabbirka cadaadiska dhiigga, X-ray, ECG, go'aaminta heerka kolestaroolka iyo unugga. muujinta saamaynta ku daweynta ee ku yidhi hab beegantay labo maalmood ka dib. Waxaa muhiim ah in la ogaado. In soo dhaweynta si wadajir ah daroogada la antispasmodics la sii kordhaya tayada shaqo ee habka daaweynta. "Theophylline" yaraynaysaa tallaabo daroogada wakiilada kahortaga shubanka. xilliga bogsashada waa in ay ahaataa si taxadar leh in la sameyn wax soo saarka kaafiinka iyo murugada.

Qaadashada daawada xilliga uurka iyo nuujinta

"Theophylline" saameyn on caloosha ku hoos category "C" ah by FDA. Qalab guskiisa ka celiyaha mandheerta. Haweenka uurka leh waxaa la odhan karaa daroogada kaliya xaaladaha halkaas oo lacagta la filayaa in hooyada waa ka weyn yahay khatarta ka iman karta in ilmaha caloosha ku. In muddada aan Bilood oo toddobaad ee uurka ugu dambeysa waa in ay qaataan daawada, logu tilmaamo adag. Waxaa muhiim ah in la xusuusto.

Of galku badan oo soo jeedinaya in ansixin theophylline inta lagu guda jiro III bilood ee uurka waa la dhimay. Tani waxay u baahan tahay waxaa laga yaabaa in go'aanka inta badan soo noqnoqda ee-fiirsashada oo ah walaxda in dhiig iyo hoos u suurto galka ah ee qiyaasta.

Naasnuujinta "Theophylline" dhacaa caanaha iyo waxay keeni kartaa astaamaha caro carruurta ama calaamadaha kale ee sumoobo. Waxaa muhiim ah in la ogaado. fiirsashada walax sheegay in caanaha naaska waa qiyaastii u dhiganta ay ka kooban tahay ee serum dhiiggii hooyada. Sidoo kale, tani waxay ka dhigan si weyn uu hakiyo jaqayo.

sababo

tilmaamaha "Theophylline" loo isticmaalo sida kor lagu sharaxay, waa u haddii ay jiraan:

• Idiosyncrasy.
• Tayroodh.
• Wadnaxanuun myocardial Ba'an.
• stenosis Subaortic. Tani waa cudur non-bararka ee ventricle bidix ee unugyada muruqa wadnaha. Waxaa lagu gartaa hadal ah meel cidhiidhi ah oo af badan oo ay saabka.
• Arrythmia.
• Qalalka iyo xaaladaha kale ee la marsiiyo.
• Uurka.

Iyada oo daryeel waxaa lagama maarmaan ah si ay u qabtaan soo dhaweynta ah ee daroogada lagu jiro muujinta cudurka kolit oo ka mid ah caloosha iyo mindhicirka yar.

shuruudaha gaarka ah

Sigaarka oo si weyn u saameeyaa qabashada shiid iyo Digo of walxaha sida sida theophylline. Waa in la xusuusnaado. Dadka sigaarka 1-2 baakad sigaar ah maalintii, waxay leeyihiin muddo ay hoos u bar-nolosha. In bukaanka qaba cagaarshowga, wadnaha ama neefsashada failure muujiyeen, sidoo kale cudurada viral iyo hyperthermia dhacdaa reebay deceleration oo ah walaxda firfircoon. Reception alaabta khamriga iyo nooca-caffeine sidoo kale uu saameyn weyn ku-shiid ee theophylline.

dhexgalka

The daroogada "Theophylline" kor u saamayn potentiation of β2-agonister ah. Waxaa kale oo kobcin kara gariirka, taas waxaa keena nooc ka mid ah daroogada sympathomimetic iyo waa awoodaa inuu xakameeyo nidaamka of nuugista phenytoin. tirtiridda tartiib ah u tahay dhacdaa in ay is dhexgalka ee "erythromycin" iyo "phenobarbital." Oo macnaheedu yahay "Theophylline" waxay bixisaa kordhiyo Digo ee kelyaha ee lithium. Xaaladdan oo kale, dheelitirka-ku-daweyn loo jeediyo in bukaanka qaadato ee cusbada u dhiganta. The daroogada "cimetidine" kordhinaya fiirsashada ee heerarka theophylline dhiig, iyo kordhiyaa waqtiga ay baxaan. Daawooyinka la saamaynta la mid ah hoos la soo daabici doonaa.

Joogitaanka waxyeellooyin

Marka la helo daawooyinka ayaa sheegay in waxa laga yaabaa in calaamadaha xun kala duwan. kuwaas oo:

• Waxaad la kulmi karaan astaamaha wareer, hurdo la'aan, madax xanuun, suuxid, walaaca, gariirka, wareer, qalalka.
• In nidaamka wadnaha iyo - arrhythmia, tachycardia, angina been ah, hoos u dhac lama filaan ah dhiig-karka, kog.
• Laga soo bilaabo nidaamka dheefshiidka - bixitaanka lallabo, matag, laab, shuban, yaaqyaaqsi, ulcerös, gastritis.
• Marka waajib ku ah hab soo dhaweynta oo laga dheehan karo daliilka qaar ka mid ah cadaanyo qaab cuncun, gubasho, urtikaria, dermatitis, qandho, dhidid iyo maqaarka finanka.

badinta

Xaaladdan oo kale, waxaa jira astaamo gaar ah. Under daliilka, kuwaas oo ku lug leh:

- cadhoodaan,

- wareer;

- gariir,

- tachycardia;

- arrhythmia;

- hypotension;

- lallabo,

- shuban;

- matag la shaydi ah oo dhiig ah,

- hyperglycemia;

- aysiidh dheefshiidka.

Marka calaamadahan lagu qoro daaweyn gaar ah. Magac ahaan, qaadeen by:

• Habka dhuxusha firfircoonaan.
• Gobolka Waraabka isku darka mindhicirka ee cusbada iyo xal-tones polyetylen.
• soo dhaweynta xididka "MCP" ama "Ondansetron" oo leh calaamado calaamadeeyay ah lalabo iyo matag.
• Reception "benzodiazepines", "Phenobarbital" (ama sodium thiopental) iyo dabcineyso muruqa durugsan at dhacdo ee qalal.

"Theophylline": dhigooda

Waxaa jira dhowr dawooyinka kala duwan ee noocan ah. Xaaladdan oo kale, tixgelin daawooyinka soo socda:

- "Teobiolong" ( "Theobilongum").

- "Spofillinretard" "(Spophillin faafiyo").

- "Perfillon" ( "PerphyUon").

- "Neoefrodal" ( "Neo-Efrodal").

- "Franol" ( "Franol").

kaydinta

The budo iyo kiniiniyada ( "theophylline") lagu kaydiyaa meel gudcur ah, oo qalalan. Ay nolosha shelf waa shan sano. shumacyo Kaydinta waa in la sameeyaa qaboojiyaha. Isla mar ahaantaana waa in aan la xayiray. Ay shelf-nolosha afar sano.

natiijada

Ka dib markii reading kor ku xusan, mid ka qiyaasi kartaa waxa a daroogada sida "theophylline", qiimaha oo la aqbali karo (gudahood 70-160 masaxo.). Sidoo kale ee qoraalkan ku xusan sheegay oo ku saabsan tilmaamaha loo isticmaalo oo ka mid ah daroogada oo ay la dhexgalo siyaabo kale.