The daroogada "Remicade": tilmaamaha loo isticmaalo, dhabta ah

Si tayo leh waxaa loola jeedaa "Remicade"? Tilmaamaha loogu isticmaalo, dib u eegista bukaanka ee dawadan lagu hoos lagu soo bandhigay doonaa. Sidoo kale in this article, waxaad ku baran doonaa oo ku saabsan xaaladaha kasta, qori daroogada, haddii waxa uu leeyahay sababo iyo waxyeello ka soo gaartey, taas oo ka kooban tahay qayb ka mid ah iyo wixii la mid ah.

Form, halabuurka

Diyaarinta "Remicade" waxaa soo saaray qaab budo lyophilized loogu talagalay diyaarinta of xal galiyey. Walaxda firfircoon ee daroogada waa infliximab. Waxa kale oo ku jira qaybaha dheeraadka ah sida polysorbate 80, sodium hydrogen dihydrate phosphate, sucrose iyo sodium laktosmonohydrat phosphate dihydrogen.

guryaha Key

Waa maxay daawada "Remicade"? Tilmaamaha Isticmaalka sheegayaa in ay tahay wakiilka ah jirka.

Socota jirka gudihiisa, daroogada bilaabmin si ay ula falgalaan foomamka L iyo transmembrane ee Alfa galleeyda buro (TNFα), laga yareeyo dhaqdhaqaaqa by formation of adag oo ah mid deggan.

khubaro Research waxay muujinayaan in walax daroogada firfircoon yaraynaysaa dhexgalka gacanta (bararka), iyo tirada calamado bararka ee meelaha ay dhibaatadu xiidmaha. Haddaba waxaa jira caafimaad si caddaalad ah oo degdeg ah ay xuub-axaleedka.

Pharmacokinetics

Maxay yihiin xuduudaha pharmacokinetic ayaa daawada "Remicade"? Fiiro gaar ah, gobolka warcelin in duro hal faleebo of infliximab qadarkuu ilaa 20 mg / kg raacay by kordhay saami in ay fiirsashada ugu badnaan.

codsiga si isdabajoog ah daroogada sababa raasamaal yar oo ah walaxda firfircoon ee serum ah.

Siyaabaha of reebay daroogada oo aan loo aqoonsan.

Tilmaamayaasha

Waayo, waxa laga yaabaa in ujeedada loo magacaabo daroogada "Remicade"? Isticmaalka daawada this lagu muujiyay xaaladaha soo socda:

• Rheumatoid arthritis foomka firfircoon (haddii bukaanka loola dhaqmo dawooyinka antiinflammatory aasaasiga ah waxay ahayd natiijo la'aan). Therapy waxaa fuliyey isku dhafan oo "methotrexate". isku darka Tani waxay u ogolaaneysaa for yareynta calaamadaha cudurka, iyo sidoo kale horumar ah ee wadajirka ah oo dhan.
• cudurka Crohn ee bukaanada qaangaarka ah. Xaaladdan oo kale waxay ka caawisaa in ay "Remicade"? Guide dhigayaa in therapy diyaarinta waa in la qabtaa haddii ay dhacdo of-diid ama waxtardarradoodu, laakiin sidoo kale la sababo in daawada caadiga ah. In cudurka sida "Remicade kor u tirtiridda dhammaan calaamadaha cudurka, dembidhaafka dayactirka iyo Caafimaadka deg deg ah ee nabarrada, xidhitaanka fistula iyo in la wanaajiyo xaaladda bukaanka.
• cudurka Crohn ee dhallinyarada. Daaweynta la daroogada this waa la fuliyay in ay dhacdo diid ama waxtardarradoodu, laakiin sidoo kale la sababo in nidaamka caadiga ah ee daaweynta. Medicament "Remicade" yaraysaa astaamaha iyo taageerada dembidhaafka iyo wanaajinaya tayada nolosha bukaannada dhallinyarada.
• Ulcerative colitis ee dadka waaweyn. Drug "Remicade", taas oo u eegay hoos lagu soo bandhigay, waxaa maamula ay dhacdo in therapy caadiga ahayd natiijo la'aan. Daaweynta wakiilka this yaraynaysaa calaamadaha cudurka, ka xabka xiidmaha bogsashada, yareynta ama la baabiiyo of qaadashada GCS. Sidoo kale waa in la ogaadaa in, ka dib shaqo ka mid ah qalabka ay meesha baahida loo qabo in uu isbitaal galo.
• Ulcerative colitis carruurta. Daaweynta la daroogada this qoray in carruurta da'doodu tahay 6-18 sano, haddii cadaato therapy caadiga ah aysan anfac lahayn.
• spondylitis Ankylosing (la karti therapy caadiga ah). Sida cudurka ka caawiyaa daawo "Remicade"? Tilmaamaha loogu isticmaalo ayaa sheegay in qalab this yaraynaysaa calaamadaha cudurka iyo hagaajinaysaa hawlaha kalagoysyada.
• Psoriasis (la karti therapy caadiga ah). Sida psoriasis caawiyo "Remicade"? khubaro Guest sheegaya in daroogada taas oo yaraynaysa bararka ee maqaarka iyo normalizes geeddi-socodka kala keratinocyte.
• arthritis psoriatic (waayo, karti therapy caadiga ah). The medicament "Remicade" maamula isku dhafan oo "MTX" ama sida monotherapy leh sababo ama dulqaad in dambaysta ah. Sidaas darteed, daaweynta hoos calaamadaha arthritis, bukaanka soo hagaagtay hawl functional, iyo sidoo kale hoos u heerka horumarka radiographic in psoriatic arthritis.

sababo

Daaweynta "Remicade" mamnuuc anshaxa marka:

• habka faafa daran (tus, sepsis, malax, qaaxada, caabuqyada fursad-) ;
• dareenka sii kordhaya ee bukaanka in infliximab iyo borotiinada murine iyo wax kasta oo qaybaha kale ee daroogada;
• da'doodu ka yar 6 sano (ulcerös kolit iyo cudurka Crohn);
• uurka;
• wadnaha,
• da'doodu ka yar tahay 18 sano,
• naas-nuujinta.

Drug "Remicade": tilmaamaha loo isticmaalo. Oo halkaas oo ay ku soo galaan (haddii oo kaliya in isbitaalka)?

daawo viewed waa in la maamulay oo kaliya iyada oo ay kormeerayaan of takhasuska (ie isbitaalka) ah oo leh qibrad ku filan oo baaritaanka iyo daawaynta guul oo ka mid ah cudurada kor ku xusan.

Xalka la soo bandhigo dropwise intravenously ka badan 120 daqiiqo. Heerka waa in aanay noqon ka badan 2 ml halkii daqiiqo. Hirgelinta hannaanka loo baahan yahay iyadoo la isticmaalayo nidaamka galiyey.

qiyaasta daawada waxay ku xiran tahay caddaynta.

rheumatoid arthritis

In shaqo ogaanshaha sida dose hore waa in ay ahaataa oo ku saabsan 3 mg halkii kg. medicament waxaa maamula si joogta ah ugu 3-6 todobaad. Markaasaa waxaa u isticmaali labadii biloodba mar.

Haddii ay dhacdo in saamaynta ay ku daweyn aan la gaarin, ka fiirsaneysa inay la joojiyo oo therapy.

Sida caadiga ah daroogada waa "Remicade" la rheumatoid arthritis wada maamula la "methotrexate".

ulcerös kolit

qiyaasta Bilowga marka cudurka sida waa 5 mg halkii kg miisaanka jidhka. Qiyaasta isku mid ah daroogada la maamulo 3-6 todobaad ka dib. Markaas daaweynta ku fuliyay laba bilood oo kasta.

Haddii loo baahdo, ee qiyaasta waa la kordhin karaa ilaa 10 mg halkii kg. Saamaynta daaweynta waxaa badanaa lagu arkay 14 todobaad gudahood. Haddii ay sidaa tahay, haddii aanay ahayn, waa in aad sii wado daawada.

psoriatic arthritis

arthritis psoriatic daroogada "Remicade" maamula in dose hore of 5 mg halkii kg. medicament waxaa maamula si joogta ah ugu 3-6 todobaad. Markaasaa waxaa u isticmaali 7-8 toddobaad kasta.

Qoro dawooyinka lagu dari karaa "methotrexate".

cudurka Crohn

In cudurka sida ee dadka waaweyn waxaa lagu muujiyey qaadasho hal of 5 mg halkii kg. Haddii saamaynta ku daweynta aan la gaari waayo, 2 toddobaad ee la soo dhaafay, daroogada rogay.

Haddii wax tallaabo ah daroogada wanaagsan, qorshayaasha soo socda:

• Xalka la durey in dose la mid ah sida in galiyey hore, iyo ka dib markii 3-6 toddobaad isticmaali. Ka dib markii in, ka dhigi irbado labadii bilood ee kasta. Haddii loo baahdo, ee qiyaasta waa la kordhin karaa ilaa 10 mg halkii kg.
• Daawada waxaa maamula at kaliya noqoshada haddii aan ka weyn yahay 16 todobaad ka dib marka la isticmaalo ugu horeysay.

cudurka Crohn ee carruurta yaryar

Crohn dhexdhexaad ah ama daran ee carruurta ka yar 18 sano waxay ku lug leedahay isticmaalka dose hore of 5 mg halkii kg. irbado Xiga waa in la sameeyaa in 3-6 todobaad. Markaas daawada loo isticmaalo laba bilood kasta haddii loo baahdo, laga beddelo si qiyaasta a of 10 mg halkii kg.

Sida caadiga ah, daroogada la weheliso immunomodulators 6-mercaptopurine, "azathioprine" ama "methotrexate". Haddii saamaynta ku daweynta aan la gaarin (for 10-11 asbuuc), isticmaalka daroogada waa loo baahnayn.

cudurka Crohn waxaa la socda fistula

Hal dose oo ah daroogada ee cudurka sida waa 5 mg halkii kg (dadka waaweyn). Daawada isticmaali 3-6 toddobaad ka dib. Haddii saamaynta ku daweynta ka dib markii 3 irbado aan arkay, ka dibna daaweyn dheeraad ah tahay mid aan habooneyn.

Iyadoo saamaynta wanaagsan ee daroogada, qorshayaasha soo socda:

• reintroduction 3-6 toddobaad ka dibna laba bilood oo kasta ka dib,
• medicament ah waxaa lagu qaataa noqoshada haddii ay qaateen wax ka yar 16 toddobaad.

spondylitis ankylosing

Sida isticmaalka daroogada cudurka "Remicade"? Tilmaamaha loogu isticmaalo wadamada in cudurkan qiyaasta hore ee daawada waa in ay ahaataa 5 mg halkii kg. Taas ka dib, daawada waxaa maamula 3-6 toddobaad ka dib.

Daaweynta waa in aan la sii haddii, lix todobaad saamaynta ma aha dareemi gudahood.

psoriasis

In daaweynta dose bilaabo psoriasis waa daroogada 5 mg halkii kg. codsiga si isdabajoog ah medicament ee maamula 3-6 toddobaad ka dib, ka dibna - mar siddeed toddobaad kasta.

Hab-diyaarinta of xal faleebo

Xalka waa in la diyaariyaa sida soo socota:

• Waxa ay xisaabin dose iyo tirada fijaan.
• budo daroogada ayaa waxaa la kala diri in 10 ml oo dareere isticmaalaya sirinj. Si arrintan loo sameeyo, ka saar furka dareeraha ku shubtay (caag ah), iyo tirtiri goolhayaha la khamriga. Irbadda la geliyo iyada oo ay xarunta, iyo dheecaanka waxaa lagu hanuuniyey derbigii.
• Xalka waxaa si taxadar leh ku kiciyeen (dhaqdhaqaaqa wareeg) ilaa waa baabba'ay budada ah. dareere Drug waa in ay ahaataa mid midab ama towns huruud ah. Haddii inta lagu guda jiro isku qasin xumbada waxay fijaankeedii ku sameeyay, waxaa lagama maarmaan ah in la nooga xal of 5 daqiiqo. The foomamka qiyaasta final laga yaabaa in qayb ka wanaagsan translucent.
• mugga guud ee daawada waxaa laga beddelo si 0.9% chloride (250 ml) ee xal sodium. Ujeedada this dareeraha diyaar lagu darayaa dhalada, kuwaas oo horey u ka kooban yahay chloride sodium. Labada qaybood waxaa si fiican isku qasan.
• Hordhac of diyaarinta waxaa lagu fuliyaa ma dambayn 3 saacadood ka dib diyaarinta xal daroogada.

Waa mamnuuc in la galo daroogada la wakiilada kale iyada oo loo marayo nidaam la mid ah. Haddii ay jiraan walxaha shisheeye ama qayb ka Doolaal in xalka, waxaa laguma talinayo.

lacagta aan la isticmaalin ee daroogada in la adeegsadaa.

waxyeellooyin

Marka la isticmaalayo medicament ah, falcelinta soo socda:

• murugada, arxandarro, walaaca kordhay, dawakhaad, somnolence, isku yaacsanaan, xusuus la'aan, psychosis, madax-xanuun,
• barar sambabada, hogaga, bronchoconstriction, dyspnea, dareen diidmo oo xasaasiyadeed, pneumonia, goror, boronkiitada, pleuritis;
• conjunctivitis, keratoconjunctivitis, endophthalmitis;
• barar iyo kaadi mareenka cudurada;
• baddu, qas ah wareegga durugsan, bradycardia, ecchymosis, hematoma, dubaaxin vascular, syncope, uurkuna waa, ku taqasuusay, petechiae, arrhythmia;
• Torombositobiiniya, dhiig yari, neytrotsitopeniya, leykotsitopeniya, lymphopenia, Lymphadenopathy, lymphocytosis;
• cheilitis, calool, cholecystitis, reflux, diverticulitis, shuban, lallabo, saxarada, beerka oo yaraada,
• finan maqaarka ah, maqaar qalalan, alopecia, seborrhea, cuncun, ka qaadmay, finan, dhidid kordhay, dermatitis, fangas, burooyinka, hyperkeratosis, erysipelas, xadgudub ku ah midabka maqaarka, qarax bullous.

Reviews of diyaarinta

Haddaba aad u ogaato sida loo isticmaalo daroogada "Remicade". Tilmaamaha isticmaalka daroogada ayaa kor lagu sharaxay.

Xaaladaha intooda badan, tixgeliyo hab si ay ula qabsadaan hawsha. Sidaa darteed, warcelin ka bukaan helay inta badan wanaagsan. Dadka isticmaala xal this, sheegay in ka dib markii la duray xanuun waxaa ku dhowaad si buuxda u tegey. Si kastaba ha ahaatee, qaar ka mid ah bukaanka ka baqaysaa tiirsanaanta, waxay keeni kartaa.