Wakiilada Antiplatelet: liiska daawooyinka. Daawada xinjirowga iyo wakiilada antiplatelet, sifooyinka ay

Kordhi dhiig inta badan sababa thrombosis taas oo horseedaysa cawaaqib daran, oo ay ku jiraan dhimasho,. horumarka Farmashiiste oggolaadaan nolosha bukaannada ku badbaadin xanuunada sida ay sabab u tahay daaweynta dayactirka sida qaata daawooyinka antiplatelet.

Waa maxay daawada xinjirowga lidka?

guryaha Rheological dhiigga isugu dheeli tiran xaga nidaamka xinjirowga iyo xinjirowga lidka ku ah. In ilaalinta dheelitirka sida daawada xinjirowga lidka ku ah dabiiciga ah ka qayb antithrombin III iyo heparin, kaas oo ka shaqeeya shaqo antithrombotic toos ah, waxa weeye, si looga hortago formation of xinjir dhiig. hab ay of tallaabo of dambe la xiriira si ay u sameeyaan adag la antithrombin III, taasoo keentay in formation of antithrombin firfircoon. Waxa uu, ka bacdi, wuxuu masuul ka yahay ku qabanaya in thrombin, taas oo aan firfircoonayn - waxay gacan ka geysaneysaa in Iscelin of formation thrombus. Antithrombin III laftiisa ayaa sidoo kale wuxuu leeyahay sifooyin xinjirowga by inactivating thrombin, si kastaba ha ahaatee, dareen-celin ka soo baxa si tartiib ah.

Awoodda heparin si loo hubiyo in inactivation of thrombin ku xiran tahay xaddiga antithrombin III ee dhiigga. dose habayn loo baahan yahay loo baahan yahay oo ku salaysan falanqaynta. Inta badan u baahan tahay magacaabidda labada daawo ee hal mar - heparin iyo antithrombin III, at qiyaasta la mid ah waxaa si gaar ah loo doortay ee qof kasta.

Qabanaya si antithrombin - ma shaqo kaliya ee heparin. Intaa waxaa dheer, inuu awoodo inuu dumin fibrin aan ka qaybgalka plasmin, waxaa lagu magacaabaa lysis non-enzymatic. reaction Tani waa formation of xeryahooda kala duwan ee walxaha bayoloji firfircoon, oo ay ku jiraan peptides iyo hormoonnada. Waxaa ka mid ah qaababka kale ee la kala saaro xakamaynta of tiro ka mid ah ensaymes ku lug leh geeddi-bararka (yaraynaysaa ay xoogooda), iyo sidoo kale hawshooda u ah ee lipase lipoprotein iyo hagaajinta socodka dhiigga ee weelasha wadnaha.

Waa maxay wakiilada antiplatelet?

Diyaargaraw xinjirowga lidka ku ah iyo wakiilada antiplatelet si waxtar leh loo isticmaalo dawada. Magacani wuxuu helay lacag, kaas oo la xakameeyo lagala kulmo ee (xulkii) unugyada dhiigga - unugyada dhiigga cas iyo xinjiraha. hab ay of tallaabo of walxaha waa kala duwan, taas oo loo ogol yahay kooxaha dhowr ah. wakiilada Antiplatelet, liiska ballaaran ee daroogada taas waxaa loo kala saaraa sida soo socota.

1. Doodeen Calcium ( "Verapamil").
2. inhibitors Insaymkaas, taas oo ka mid ah walxaha cabudhinayo cyclooxygenase (acetylsalicylic acid, "naproxen", "indomethacin") iyo cyclase ku adenylate iyo phosphodiesterase ( "Ticlopidine", "Pentoxifylline").
3. Daawooyinka kicin formation of prostacyclin ( "pirazolinov").
4. Prostanoids ( "Prostacyclin" iyo analogues asal dardaro ay).
5. Daawooyinka lagu cabudhinayo dheecaanku ka mid ah walxaha ku jira platelets ( "Pyracetam").

maragga

daroogada Antiplatelet - daroogada magacooda lagu yaqaan in ay dad badan oo ay sabab u tahay codsiga ballaaran. Shaqada ugu weyn ee group this - of prophylaxis thrombosis. daroogada Antiplatelet - daawooyin wax ku ool ah u codsan in tiro ka mid ah heley wadnaha, iyo sidoo kale ka dib markii qaliin (filtarka wadnaha bedalay).

wakiilada Antiplatelet: liiska daawooyinka caadi ahaan loo isticmaalo in dhaqanka caafimaad

Daawooyinka ka tirsan kooxdan, ilaa xad badan, oo kulligoodna waxay lahaan dhegyadii iyaga u gaar ah. Selection of daroogada waxay ku xiran tahay kiiska caafimaad. Iyo, dabcan, is-daawo xaalad this tahay mid aan habooneyn.

"Aspirin"

In sharciyeynta eicosanoids hemostasis waa qayb kuwaas oo ka soo baxay ee lagu qayilo ee arachidonic acid. Waxaa ka mid ah kuwa ugu muhiimsan ee A2 thromboxane, iyo shaqo ugu weyn - hubinta xulkii dhiig xinjirowga. tallaabo ee aspirin la faray in Iscelin of enzyme ah, loo yaqaan cyclooxygenase. Sidaas darteed of Avv this u dhigan tomboksana A2, sidaas daraaddeed dhaxalsiiyeen geedi socodka samaynta thrombus. Saamaynta kordhiyaa marka dib-u-qaadashada daroogada ay sabab u raasamaal. Waayo, Iscelin dhamaystiran oo cyclooxygenase baahan yahay qaato maalin. qiyaasta si mug leh u yaraynaysaa suurtagalnimada waxyeellooyinka, "Aspirin" xataa iyadoo la isticmaalayo joogto ah. Qiyaasta kordheen aan la aqbali karin, tan iyo markii ay jirto halista jahawareerka dhiig.

"Ticlopidine"

daawooyinka waxay ku saleysan yihiin xanibeen receptors gaar ah in ka mas'uul ah xinjiro dhiig yihiin. Caadi ahaan, marka aad link iyaga jiro isbeddel ah ee ADP xulkii dhiig xinjirowga shidan oo u qaabeysan, iyo "Ticlopidine" hakiyo geedi socodka this. feature A of wakiilka antiplatelet waa bioavailability sare, oo waxaa lagu gaarayaa by nuugid xawaaraha sare. Ka dib markii la kansali saamayn lagu arkay xataa 3-5 maalmood. khasaare waa tiro badan oo ah waxyeelo, taas oo ka mid ah lallabo caadiga ah, shuban, dhiig iyo Agranulocytosis.

"Clopidogrel"

wakiilada Antiplatelet sida ay nooca tallaabo la mid tahay "ayuu ticlopidine", laakiin ay faa'iido waa sumoobo ka hooseeya marka loo eego. Intaa waxaa dheer, halista waxyeellooyinka markii qaadashada daroogada tani waa aad uga hooseeya. Waqtigan xaadirka ah ku takhasusay siin doorashada si "clopidogrel" sabab u tahay maqnaanshaha dhibaatooyin kale sida Agranulocytosis iyo Torombositobiiniya.

"Eptifibatide"

daroogada wuxuu ku siinayaa xulkii by xanibeen glycoprotein ah, oo ku yaalla xuub dhiig xinjirowga ku. Qoondeeyay bolusdose xididka, sida caadiga ah ee angina iyo angioplasty si loo yareeyo suurtagalnimada of Wadnaxanuun myocardial.

"Dipyridamole"

Saamaynta ugu weyn ee daroogada - vasodilatation tiirsan, sida ballaarinta xididdada dhiigga, laakiin muujiyeen saamaynta antiplatelet lagu arkay marka daawooyin kale oo la isku daray. "Dipyridamole" with "aspirin" magacaabay, haddii ay jirto halis sare u ah xinjiro dhiig. Waxa kale oo ay suurogal tahay in lagu biiriyo ah "warfarin", taas oo si wax ku ool codsatay markii waalka wadnaha bedalay in uu yareeyo suurtagal ah embolisms. In monotherapy saamayn ka yar fahmayaan.

daroogada Antiplatelet - daroogada (liiska: "Elikvis", "clopidogrel" iyo kuwa kale), waxaa si balaadhan looga isticmaalaa in ku dhaqanka.

sababo

Magacaabidda therapy antiplatelet u baahan tahay taariikhda taxaddar, taas oo ka mid ah warbixin ku saabsan cuduro kale. In jiritaanka cudurkan oo contraindication ah qaata daawooyinka kooxdaan, iyo hagaajinta qorshaha daaweynta. Xaaladaha noocaas ah, oo xul ah ee daawooyinka qofka iyo qaadashada, iyo daaweynta waxaa lagu fuliyaa ka yar kormeer caafimaad adag. Xaaladdan oo kale ma ballan madax banaan wakiilada antiplatelet, maxaa yeelay, natiijadu waxay noqon kartaa musiibo doonaan.

Liiska sababo:

• xasaasiyad,
• diathesis hemorrhagic,
• halista ah ee dhiig-bax,
• beerka iyo kelyaha ba'an la'aan;
• taariikhda arrhythmia;
• hypertension, oo daran;
• cudurada obstructive nidaamka neef-mareenka;
• da'da carruurta ee (ee wax soo saarka ugu badan).

Intaa waxaa dheer, dad badan oo ka mid ah wakiilada antiplatelet (liiska alaabta dib loo eego in this article) yihiin xilliga uurka iyo nuujinta. Muddadan, waa in la door bido daawooyinka in ay yihiin ammaan ee ilmaha iyo hooyada.

wakiilada Antiplatelet. Daroogada: liiska uurka

Haddii aad ku xad-wareegga uurjiifka halista ah ee ilmo iska soo ridid. Tani waxay ifafaale waxaa lagu magacaabaa la'aan fetoplacental. Haddii aad ku xad-gaarsiinta ogsajiinta dhiigga ilmaha caloosha ku koraya hypoxia daran, taas oo halis ma aha oo kaliya kala duwanaanta dhinaca horumarinta, laakiin sidoo kale dhimashada. Marka baaritaanka cudurada u baahan daaweyn degdeg ah, taas oo ka kooban in hagaajinta socodka dhiigga, yaraynta nafwaayay dhiigga. Waayo, kanu iyo wakiilada antiplatelet magacaabay, si kastaba ha ahaatee, in ay ogaadaan in dhammaan daawooyinka kooxdaan ma aha ammaan inta aad uurka leedahay. Suurto gal ah in la isticmaalo oo kaliya qaar ka mid ah lacagaha.

"Kurantil"

daroogada waa mid aad u caan ah oo ay sabab u tahay xaqiiqada ah in ay liiska sababo ma uurka iyo nuujinta. Walaxda Firfircoon "ogashahay" - dipyridamole hore ku tilmaamay, taas oo weynaadaa xididdada dhiigga iyo hakiyo formation thrombus. Waxaa hagaajinaysaa socodka dhiigga myocardial, hubinta bixinta lacagta loo baahan yahay ee ogsijiin. Sidaas, K "Urantia" waxaa loo isticmaali karaa in jiritaanka cudur wadnaha ee haweenka uurka leh. Si kastaba ha ahaatee, ay calaamad ugu weyn ee uurka leh waa failure placentofetal. By hagaajinta guryaha rheological dhiigga iyo vasodilatation, weelasha urka ka hortagga mandheerta, si ilmaha caloosha ku ma ay dhibaatadu ka hypoxia. Faa'iidada A dheeraad ah ee daroogada la odhan karaa saamayn immunomodulating. Daawada wuxuu kobciyaa soo saarka ee interferon, oon ku yareeyo halista cudurada viral in hooyada. In kasta oo "Kurantil" iyo waxa loo isticmaali karaa xilliga uurka iyo nuujinta, laakiin waa in ay qoraan oo keliya haddii la tilmaamay. Iyadoo qaadashada daroogada waa in la yareeyo isticmaalka shaaha iyo kafeega sida ay hoos u ah waxtarkeeda. daroogada Antiplatelet - daroogada (liiska kor ku xusan) in aan la ogoley in lagu sakhraamo noocan oo kale ah. Inkasta oo uurka aan iyaga lagula talinayaa in ay ka qayb qaataan hab kasta.

wakiilada Antiplatelet, liiska daawooyinka oo ay ku jiraan daraasiin magacyada, si waxtar leh loo isticmaalo daawaynta cudurada nidaamka wadnaha iyo. Si kastaba ha ahaatee, la soco oo ka mid ah dhibaatooyinka ay suurtagal tahay la xidhiidha hoos ku nafwaayay dhiigga iyo Iscelin xinjirowga. daroogada Antiplatelet - daroogada oo loo isticmaali karo oo keliya iyada oo ay kormeerayaan dhakhtarka xaadirka ah, ayuu kor u soo qaado doonaa qiyaasta loo baahan yahay oo dabcan ka mid ah daaweynta.