The daroogada "Carboplatin": tilmaamaha loo isticmaalo, analogs iyo dib u eegis

Maxaa bedeli karaa daroogada this sida "Carboplatin"? Analogs daroogada this hoos ku tixi doona. Sidoo kale in qalabka of this article loo soo bandhigi doonaa macluumaad ku saabsan isticmaalka saxda ah ee lacagaha la sheegay, tilmaamo ay, waxyeelo iyo sababo.

description Curiska, qaabka medicament ah

In waxa foomka waa daroogada la heli karo "Carboplatin"? saaraha ayaa sheegay in qalab la iibsan karaa sida budada cad lyophilized loogu talagalay diyaarinta of xal xididka. Its qayb firfircoon waa carboplatin, iyo dheeraad ah - mannitol.

In iibinta shancosbitaal duray "Carboplatin", oo sideeda oo ka mid ah oo aynu kor ku soo bandhigay, ku yimaado dhalooyin in waxaa la geeyaa bokisyada.

guryaha pharmacological

Waa maxay daawada "Carboplatin"? Tilmaamaha warbixinta isticmaalka, warcelin waa xarunta imanba adag oo ay ku jiraan biraha culus sida platina.

Khubarada ayaa soo jeedinaya in hab ay of tallaabo of qalab this waxaa sabab u ah awoodda ay leedahay in loo xidho DNA. Sidaas darteed, la aasaasay vnutrispiralnye crosslinking bedeli dhismeedka DNA oo la xakameeyo ay Avv. Saameyn la mid ah waxay dhacdaa iyadoo aan loo eegin waji wareegga gacanta. Waa in la ogaadaa in carboplatin fuuq, inta lagu guda jiro taas oo la aasaasay foomka firfircoon ee daroogada waa badan gaabis ah ka badan fuuq ee cisplatin.

beegyada uu ogeed of medicament ah

Sidee jidhka bini'aadamka waa "Carboplatin" qaybinta daroogada? Tilmaamaha loogu isticmaalo sheegayaa in ka dib markii maamulka keli ah wakiilka this ee foomka of faleebo (iv) 60 daqiiqo, in fiirsashada dhiigga free (i.e. ultrafiltration kasteba) iyo guud ahaan hoos u platina waafaqsan model laba-waji ah pharmacokinetics si ugu horreeyey.

Laga bilaabo wakhtiga free platina-nolosha qiyaastii 2 saacadood, iyo T1 terminal a / 2 - 3-6 saacadood. Sidoo kale waa in la ogaadaa in platina guud waxa lagu gartaa la mid ah hore ee nus-nolosha, laakiin at the dhamaadka-dheer (oo ku saabsan maalinta a).

Maamulka isdabajoog ah daroogada ee 4 maalmood oo isku xigta ee raasamaal dhiigga platina ah ayaa lagu arkay. Ka dib markii maalin ka dib markii codsiga ah ee daroogada ah oo ku saabsan 85% ka mid ah qayb firfircoon ee plasma ku xidhan tahay in ay xaalad borotiinada.

Sidee tirtiridda daroogada "Carboplatin"? Guide ayaa sheegay in diyaarinta qayib inta badan kelyaha (ku dhowaad 30% ee qiyaasta sii daayay qaab unmodified).

In aadanuhu CS 60 ml / min oo kor ku xusan oo ku saabsan 65% iyo 70% wax soo saarka dhanka Electricity loo isticmaalo 11 iyo 23 saacadood, siday u kala horreeyaan.

Tan iyo tirtiridda "Carboplatin" qaadataa meel ku dhow gebi ahaan sifeynta glomerular, kaliya fiirsashada yar oo lagu arkay ugu tubules kelyaha, kaas oo sharxaya awood u hooseeyo nephrotoxic daroogada marka loo eego cisplatin.

daroogada Anticancer "Carboplatin": maragga

Xaaladaha qaarkood, muujinaysaa isticmaalka daroogada hoos tixgelin? Sida laga soo xigtay tilmaamaha, waa lagu daaweyn ah burooyinka soo socda:

• kansarka ugxansiduhu,
• kansarka afka minka;
• burooyinka cell jeermiga in rag iyo dumarba,
• sarcoma osteogenic;
• kansarka sanbabada,
• medulloblastoma;
• barar ah qoorta iyo madaxa.

Oo mamnuucday isticmaalka xal faleebo

Waa maxay daawada sababo leeyahay "carboplatin"? Isticmaalka daroogada waxaa ka mamnuuc ah haddii:

• naas-nuujinta,
• heley halis kelyaha (tus, CC wax ka yar 15 ml / min);
• uurka;
• diidmo in carboplatin iyo daawooyin kale, oo ay ku jiraan platina ah;
• myelosuppression daran;
• dhiig la'aan weyn, oo ay ku jiraan kuwa lagu arkay ee la soo dhaafay dhawaan,
• ee carruurnimada.

Sidoo kale si taxadir leh daawada waxaa loo qoray, waayo,

• tallaalka dhawaan;
• maqalka;
• cudurada kelyaha,
• hematopoiesis dhuuxa lafta niyadjab, oo ay ku jiraan xaaladaha ka dib markii radiotherapy iyo chemotherapy;
• isticmaalka isku midka ah ee daroogada nephrotoxic (tus, "Cisplatin");
• caabuqyada ba'an ee viral, fangas iyo asal bakteeriyada.

Medicament "Carboplatin": tilmaamaha loo isticmaalo

Sidee Lagu Daweyn daroogada anticancer ah waa in la isticmaalaa? Sida laga soo xigtay khubaro ah, medicament this lagu saleyn karaa sida monotherapy ah, ama isku dhafan oo siyaabo kale oo saamayn la mid ah (tus, isku dhafan oo "Paclitaxel" diyaarinta).

Iyada oo ku xidhan waxa size iyo meesha bukaanka waa kooban buro, dhaqaatiirtu waxa ay isticmaali kacmaha kala duwan "Carboplatin". Waa in la intravenously maamulo sida faleebo ah in ka badan 17-55 daqiiqo.

Sidee baan u isticmaalaa daawada "Carboplatin"? Hagaha dhibcood u qaadashada socda qalab this:

• 100 mg / square meter jirka bukaanka maalin kasta muddo 5 maalmood ah;
• 300-400 mg / mitir laba jibaaran oo ah bukaan socodka, mar 4 toddobaad kasta.

Waa in la ogaadaa in bareeg u dhexeeya maamulka of daroogada, ee tiro ka mid ah 100 kun oo platelets / mm iyo 1.5 kun oo neutrophils / mm, waa in ay ugu yaraan 4 todobaad.

Ka hor iyo ka dib codsiga ah "carboplatin" cabitaanno qaban dheeraad ah iyo sidoo kale fulinta diuresis khasabka ayaa loo baahan yahay.

Haddii bukaanku leeyahay sumoobo daran hematological ama dhexdhexaad ah waxaa laga yaabaa in u baahan tahay si loo yareeyo qiyaasta of daroogada si uu 26%.

Marka heley kelyaha la taaban karo u kordhiyaa halista ah ee saamaynta sun ah ee daroogada, oo sidaas daraaddeed loo yareeyo qiyaasta ku salaysan heerka CC ah.

In dadka waayeelka ah, iyo sidoo kale horay u sameeyay therapy myelosuppressive, qiyaasta waa in la dhimay by 22-25%.

Ka hor inta in ay isticmaalaan, xal galiyey waa in ay qabtaan oo ay kormeerka muuqaal ah si loo ogaado haddii ay jiraan waa wax qalad ah in midabka ama nijaasta ahaa.

Maxaa qasan kartaa daawada budada "Carboplatin"? Tilmaamaha loogu isticmaalo ee sheegaya in daroogada firfircoon waa in lagu qasi in glucose xal 5% ama chloride sodium 9%. Xaaladdan oo kale fiirsashada arkay waa in ay ahaataa 0.5-1 mg / ml.

xal Daawada waa in la diyaariyaa wax yar ka hor waxaa la isticmaalayo, tan iyo nolosha shelf ugu badan ee diyaarinta kala duwan waa u siman yihiin in ay hal maalin.

Waxqabadka by-qof

Maxaa falcelin xun keena daroogada "Carboplatin"? Reviews oo ku saabsan qalab this sheegan in ay ka cadhaysiiyaan karaan horumarinta saamaynta xun ee soo socda:

• xubnaha caloosha iyo mindhicirka: 11-12 saacadood isticmaalka daroogada ka dib, bukaanka waxaa laga yaabaa in ay la kulmaan lalabo iyo matag. khatarta hoos u reactions emetic isticmaalaya dhaweynta hore antiemetics, iyo sidoo kale maamulka go'aysa ee medicament ah muddo 5 maalmood ah, ama faleebo a joogto ah xididka maalmo. Sidoo kale, qaar ka mid ah bukaanka lahaa dhibaato sida shubanka, calool xanuun, caabuq afka iyo caloosha oo.
• nidaamka hematopoietic: isticmaalka qaadasho sare ee "carboplatin" xakamayn kartaa shaqo ee hematopoiesis dhuuxa lafaha. Sidoo kale, tiro badan oo ah dadka bukaanka ah calaamadaha cad ee anemia, xoogga taas oo ku xiran qiyaasta of daroogada loo isticmaalo. Inta badan kala kulantay iyo dhibaatooyin caafimaad oo ay ka mid yihiin cudurada faafa, xummad, dhiig-bax iyo septic shock.
• NA durugsan iyo bartamaha habdhiska: jirto suurtagalnimada sare ah horumarinta neuropathies durugsan, iyo sidoo kale hoos u of hummaag seed u qoto dheer, gaar ahaan dadka ka weyn 65 sano. Intaa waxaa dheer, astaamo ay suurtogal tahay habdhiska xanuunada hawlgalka. daaweyn muddo dheer la daawada keeni kartaa neurotoxicity wadareed.
• HAY'ADAHA aragga, in isticmaalka lacagaha ay u badan tahay in sii daraysa ku meel gaar ah ama khasaare dhamaystiran oo aragti, iyo luminta awood u leh inay iftiinka u arkaan iyo kala saaro midabada. dib u soo celinta Sight iyo horumar sida caadiga ah dhacdaa dhowr toddobaad gudahood ka dib markii joojiyo of daroogada. In dadka qaba shaqada kelyaha oo yaraada, kuwaas oo lagu daaweeyaa qaadasho sare ee daroogada, arkay indho cortical.
• xubnaha maqalka: hordhaca ah ee "Carboplatin" in bukaanka qaar ka mid ah waxaa jira ototoxicity, taas oo u muuqato in qaab maqal la'aanta iyo tinnitus.
• Xasaasiyad: qandho, erythematous finan, pruritus, anaphylactic reaction, urtikaria, hypotension iyo bronchospasm. Saamaynta waa ay dhici karaan in dhowr daqiiqo ka dib markii maamulka daroogada. Sidoo kale, marmar dhif ah, bukaanada la kulmi kartaa dermatitis exfoliative.
• nidaamka Kelyaha: hordhaca ah ee "Carboplatin" bukaanada qaar la kulmaan koror ku meel gaadh ah oo khafiif ah in ay isugu soo urureen daroogada dhiigga iyo HOL. Xaaladdan oo kale, dhaawac ba'an kelyaha waa mid aad u dhif ah. Halista nephrotoxicity ku saabsan asalka ah ee isticmaalka wakiilka wuxuu kordhiyaa qiyaasta, iyo sidoo kale dadka horay loola dhaqmo si cisplatin.
• dheelitirka elektrolytka: hypocalcemia, hypokalemia, hypomagnesemia, iyo hyponatremia.
• Beerka: kororka ku meel gaar ah ee ay isugu soo urureen bilirubin, ACT iyo phosphatase xumadoodu in dhiigga laga dheehan karo. Dadka la daaweeyaa qaadasho sare ee daroogada si uu autologous dhuuxa lafaha, lagu arkay khaladaad beerka.
• Dareen-celinta kale: syndrome hemolytic-uremiskt, daal, alopecia, gabsiiya wadnaha, calaamadaha hargabka oo kale, myalgia / arthralgia, dareen diidmo oo xasaasiyadeed, xanuunada cerebrovascular.

macluumaad gaar ah

Maxaan bukaan ogaado ka hor inta la isticmaalayo daawada "Carboplatin"? Tilmaamaha, comments ku doodaya in galiyey of daroogada this kaliya iyada oo ay kormeerayaan joogta ah shaqaalaha caafimaadka la fulin karo, oo ku takhasusay daaweynta wakiilada cytotoxic. In this monitor suurto gal waxyeello sun optional, gaar ahaan marka qaadasho sare ee daroogada.

In koorsada of therapy wakiilka this iyo in ka badan saddexda bilood ee soo socota, bukaanka waa in ay isticmaalaan uurka lagu kalsoonaan karo.

Waayo, diyaarinta iyo maamulka xiga ee xal daroogada loo baahan yahay in la isticmaalo sahay caafimaad aan aluminium ku jira. Tan waxa u sabab xaqiiqda ah in marka uu ula dhaqmo soo dadajin daroogada waxaa la aasaasay iyo hoos u oggolyahay daroogada calaamadeeyay.

Inta lagu jiro daaweynta, "Carboplatin" looga baahan yahay imtixaanka dareemayaasha wareegsan, oo ay ku jiraan dadka waayeelka ah iyo hore loola dhaqmo si cisplatin.

Isticmaalka daawada waxay keeni kartaa in horumarka saamaynta iyadana, oo sidaas daraaddeed-daaweyn pre Waa in la fuliyo tijaabooyin audiometric.

Iyada oo ay kormeerayaan of a xadgudubyada Caafimaad ahaan la taaban karo ee dhagaysiga laga yaabaa in u baahan tahay a dose sixitaanka "Carboplatin" ama ay dhamaystiran la baabiiyo.

Haddii sheyga galo maqaarka ama indhaha, isla markiiba ku luqluqo biyo fara badan. Haddii liqay, habka loo baahan yahay si wax looga qabto caawimo u qalma.

daawooyinka la mid ah

Maxaa analogues daroogada lagu beddeli karo "Carboplatin"? Tilmaamaha loogu isticmaalo kuma jiraan saaraysa warbixin lahayn. waxaa Behind waxaad yeelan doontaa in ay soo jeedin dhakhtar khibrad leh. Sida caadiga ah, khubaro ku talinaynaa isticmaalka analogues kuwan "Carboplatin" "Tsitoplatin", "Teksalok", "Displanor", "Oksiplat", "Oxaliplatin", "Platinol", "Cisplatin", "Eloxatin", "Platikad", "Plaksat "" Oksitan "," Oksatera "," Ekzorum ".

Reviews daroogada anticancer

Haddaba aad u ogaato sababta aad u baahan tahay daawada noocan oo kale ah sida "Carboplatin" ( "Carboplatin Teva"). Tilmaamaha loogu isticmaalo daroogada this ayaa sidoo kale kor lagu sharaxay.

Qiimeynta bukaanka sumoobo iyo Diidmada ay of "carboplatin" daroogada waa lagu muransan yahay. Dadka qaarkood waxay ka hadlaan natiijooyinka fiican daaweynta kansarka kala duwan oo kale oo aad u badan ku xuso saamaynta sun ah ee daroogada on xubnaha kala duwan ee aadanaha iyo nidaamyada, iyo sidoo kale ifafaale kale oo xun. Khubarada ayaa sheegaya in waxa la xidhiidha dulqaad u gaar ah bukaanka oo ah walaxda daroogada firfircoon iyo xaaladda guud ee ay. Si kastaba ha ahaatee waxay u baahan yihiin chemotherapy kansarka. Haddii daroogada "Carboplatin" bukaanka ma ku haboon yahay sabab qaar ka mid ah ama mid kale, ka dibna waxaa la bedelay analogs. Tani daroogada antitumor bedelka ka caawisaa in 90% ka mid ah xaaladaha.