The daroogada "salofalk": analogs iyo tilmaamaha loo isticmaalo

jidhka bini'aadamka la dhibtoonaya noocyo kala duwan oo cudurro, fudud oo adag, naftiisa oo dhan. Far ka ugu dambeeyey ee taxane ah oo dhibaatooyin caafimaad mashquulin cudur mindhicireed barar. Si ay iyaga la dagaallami si ay u horumariyaan tiro ka mid ah daawooyinka kala duwan mabaadiida kala duwan ee ficil.

mesalazine Maandooriyaha waa qayb maamulaha koox ku filan badan oo dawooyinka ( "salofalk" analogs) si loola dagaallamo cudurro mindhicirka bararka gaar ah.

Curiska "salofalk", pharmacodynamics

Sida hore loo sheegay, qayb weyn ee firfircoon yahay medicament mesalazine. Sida kaabayaal u adeegtaa tiro ka mid ah qaybaha, gaar ahaan, sida carbonate sodium, glycine, povidone, cellulose mikrokristallin, silicas, iyo titanium, milmahayn calcium, sodium croscarmellose, hypromellose acetate ugu weyn butylmethacrylate.

hakiyo "Salofalk" (dhagaxyada ah, kiniin, dabada, ganaax) (depresses) geedi socodkii nuutrofilkaagu iyo Avv lipoxygenase in aadanuhu prostaglandins iyo leukotrienes. walaxda firfircoon yaraynaysaa heerka of socdaalka, phagocytosis iyo degranulation of neutrophils, yaraynaysaa dheecaan ee limfosaytis. Intaas waxaa sii dheer, medicament waa awood u ku qabanaya xagjirka lacag la'aan oo markii danbe baabbi'in iyagii, i.e. muujinayaa saamayn antioxidant. Sidoo kale mesalazine awood u ku qabanaya la xagjirka lacag la'aan soo sameeyey noocyada ogsijiin Waxyeelo.

Tilmaamayaasha loo isticmaalo

Meesha ugu weyn, taas oo laga helay isticmaalka "salofalk" - daaweyn for ulcerös kolit iyo cudurka Crohn.

Cudurku wuxuu marka hore waa hab chronic bararka ayaa weli ma caddeeyo dabeecadda. Its horumarinta waxaa keena dhexgalka ah sababo hidde iyo xaaladaha deegaanka.

cudurka Crohn lagu gartaa karaa sida caabuq granulomatous chronic of mareenka caloosha iyo mindhicirka. Marxaladani waxay qabsan karaan dhammaan qaybaha habka dheefshiidka, waxay saamaysaa dhamaan lakabyada tube dheefshiidka. natiijo waxay noqon kartaa horumarinta lymphadenitis, ulceration iyo nabaro xagtin gidaarka mindhicirkaaga ma aha.

Form sii daayo daroogada

Soo-saareyaasha ayaa bixiyaan macaamiishooda "salofalk" daroogada (la mid ah saaraysa kala duwanaan karaan) in a noocyo dhowr kala duwan ee wax soo saarka.

In foomka kiniinka ku jiri kara 250 ama 500 mg ah qayb weyn ee firfircoon - mesalazine. In mid ka mid ah bacda ku jiri kara 500 mg ama 1 g oo ah walaxda ugu weyn. medicament The qaab dabada (dabada maamulka malawadka) sidoo kale waxaa laga heli karaa laba qaadashada - 250 iyo 500 mg ah qayb weyn ee. Sidoo kale waxaa laga iibsan karaa farmasiyada iyo ganaax xumbo maamulka malawadka. The ugu waxtarka badan ee foomka fasaxa bukaanka kasta oo gaar ah kaa caawin doona inaad dooratid dhakhtarka ku dawaynaya.

kiniiniyada keeneysa in mudada

qiyaasta Standard ee dadka waaweyn - saddex jeer maalintii 500 mg. Haddii la degree daran cudurka laga helay, dhakhtarka dhigto wuxuu xaq u leeyahay in la kordhiyo qiyaasta inay 3-4 g maalintii. Dabcan ee therapy socon kartaa 2 ilaa 3 bilood. Haddii dawada loo qaato sida qiyaas ka hortag ah, waxaa la sameeyaa by nidaamka caadiga ah (1.5 g saddex qiyaasood oo lagu jiro maalinta).

Codsiga salofalk "User bukaanka ka yar '(analogs kala duwanaan karaan in mudada qiyaasta) ayaa ku talineysa in ay bixiyaan si waafaqsan miisaanka ilmaha. Ilmaha la miisaanka jidhka aan ka badnayn 40 kg, dhakhtarka kuu qoray 250 mg ah ee daawada saddex jeer maalintii. Haddii miisaanka ilmaha ka badan 40 kg, waxa uu muujinayaa qiyaasta la mid ah sida loogu talagalay dadka waaweyn: 500 mg saddex jeer maalintii.

Kiniiniga waxaa fiican in la qaato marka la dhameystiro hadhuudhka ah, ma caynkan ah oo cab badan oo dareeraha (doorbidayaa oo biyo ah).

Nidaamku wuxuu of dhagaxyada ah

Foomkan sii daayo "salofalk" daroogada (dhagaxyada ah) waxaa loo doortay uu dhakhtarka xaadirka ah gaar ahaan si gaar ah, oo ku salaysan guud ahaan sawirka caafimaad ee caafimaadka bukaan-socodka. Xaaladaha intooda badan inta lagu jiro sii daridda ah ee ulcerös kolit bukaanka waxaa loo xilsaaray in ay helaan qiyaas 500 mg ama 1 g saddex jeer inta lagu jiro maalinta (t. E. mugga maalin walba ah ee medicament waa ka 1.5 ilaa 3.0 g). Waxaad qaadan kartaa dose hal mar 3 bacaha. Haddii bukaan-socodka waa in dembidhaaf, "salofalk" qaataan qiyaas 1.5 g maalin kasta, waayo, taasu waxa loo qaybin karaa 3 qiyaasood oo qaaday ama dhammaan daroogada mar.

Haddii aynu ka hadlayno sii daridda ah ee ulcerös kolit carruurta (laga bilaabo 6 sano iyo ka weyn), dhakhtarka xaadirka qoray daroogada at heerka of 30-50 mesalazine mg halkii 1 kg ee miisaanka. dose oo dhan waxaa laga yaabaa in hal mar ama kala qaybiyey 3 jeer maalintii oo dhan.

dhagaxyada ah waa in la dilaa on carrabka iyo, iyada oo aan lagu calaaliyo, liqidda. Daawada waa in ay cabaan cabitaano badan. Si saamaynta ay ku daweyn jiray dhagaxyada ah u adkaysta waa in si joogto ah iyo si joogto ah loo qaaday. stage Xiisad of ulcerös kolit badanaa dhinto 2-3 bilood gudahood, dose maalin dheeraad ah oo la aqbali karo hoos u dhigay 1.5 g maalintii.

Ujeedada iyo hab codsiga of dabada

Buuggan "Salofalk" (shumac) edbinta ku talinaysaa qiyaasta a of 500 mg (1 malawadka saboostada 500 mg ama 2 - 250 mg) saddex jeer maalintii. Haddii cudurka in marxaladda ba'an, qiyaasta maalin kasta waxaa loo laalaabi karo. Haddii bukaanka lagu meeleeyo Dabcan dheer daaweynta ama qaabilaadda target - Gaarna profilatikada (ka hortagga labakaclaynta), qiyaasta caadi ah kiiskan waa 250 mg (1 shumac) saddex jeer inta lagu jiro maalinta.

Bukaanka ka yar qiyaasta ku xiran tahay miisaanka jidhka. Carruurta oo miisaankeedu yahay in ka yar 40 kg "salofalk" (shumac) tilmaamaha loo isticmaalo dejisa magacaabi ½ qiyaasta dadka waaweyn ah, t. E. 250 mg saddex jeer maalintii. Haddii miisaanka ilmaha ka badan 40 kg, waxaa loo qoondeeyey in qiyaasta daawada sida bukaanada qaangaarka ah (saddex jeer maalintii 500 mg).

ganaax rectal

Drug "salofalk" - ganaax waa la heli karo in dhalada la siiyo maamulka malawadka. Nidaamka waxaa la sameeyaa hal mar fiidkii ka hor wakhtiga jiifka. Bukaanka ayaa ka hor maamulka ka mid ah daroogada lagu talinayaa in la sii daayo mindhicirka. Inta ay maalin walba ah ee daroogada la doortay isagoo ku salaysan miisaanka bukaanka (marka la eego 30-50 mg / kg). Haddii uu cudurku waa daran ama waa in geeddi-socodka lagu soo kordhay, qiyaasta ugu badan ee lagu jiro maalintii ay gaari karaan ilaa 3 sano si looga hortago soo noq khubarada sida caadiga ah ku talinaynaa qaadashada "salofalk" afka (kiniin). Xaaladdan oo kale qiyaasta (maalin) waxaa sidoo kale loo xilsaaray in ay miisaanka - 15-30 mg / kg miisaankiisa jirka. All mugga maalin kasta daawada maalintii oo dhan waxaa lagu talinayaa in la kala qaybiyaa laba marxaladood.

Sababo in la helo "salofalk"

Isticmaalka "salofalk" daroogada (analogues - waa laga reebo lahayn) waa u siiyo dadka qaba diidmo in qaybaha ugu muhiimsan iyo kaabayaal ah ee daroogada. Waxa aan la aqbali karin in uu magacaabo kiniiniyada in ay carruurta ka yar 3 sano jir, dhagaxyada ah - 6-sano jir ah. Ma aha in aad in ay qaataan daawo si ay dhibaatada bukaanka laga la'aan kelyaha ama cagaarshowga daran.

Ha magacaabi dadka "salofalk" kuwaas oo u janjeera in ay yeeshaan dhiig-bax, cudurro kala duwan nidaamka hematopoietic. Ka cabanaya nooca diathesis hemorrhagic cudurka boog of mareenka caloosha iyo mindhicirka kasta oo sidoo kale waa in aan qaato daawo ku salaysan mesalazine.

dhagaxyada medicament The aan la aqbali karin ay maamusho si ay bukaanka ka cabanaya phenylketonuria (cudur la iska dhaxlo ee la xidhiidha-shiid oo yaraada ee phenylalanine keenaysaa in lesions daran habdhiska dhimirka ee foomka of caqliga naafada ah).

Iyadoo la tixgelinayo in haweenka uurka leh iyo kuwa nuujinaya, isticmaalka daroogada ee 3 bilood ee ugu horreysa ee uurka waa in la xaq ku tilmaamo adag. Muddo 2-3 trimester ballan "salofalk" ayaa suuragal ah keliya marka xaaladaha saamaynta ku eedeeyay dhinaca caafimaadka naagta ka taliso halista suurtagalka ah ee ilmaha. Sida laga soo xigtay maragga isku mid la aqbali karo si aad u dalbato dhagaxyada ah ee 'salofalk "nuujinta. Si kastaba ha ahaatee, haddii ilmuhu uu leeyahay shuban, waxaa lagama maarmaan ah in ay dayacaan naas-nuujinta. Iyo guud ahaan, loogama qorsheeyay ka hor bilawga ah ee uurka, joojisid qaadashada "salofalk" ama, ugu yaraan, la yareeyo qiyaasta helay.

waxyeelooyinka suurogalka ah

Dhibaatooyinka ay keento yihiin ku dhowaad daroogo kasta. Waxaa jiray marka laga reebo iyo "salofalk" (dhigooda Ruush iyo sidoo). waxyeelo habdhiska waa calaamado ay suuragal tahay sida madax xanuun, wareer, gariir, tinnitus, murugada, gariir, paraesthesia. mareenka caloosha iyo mindhicirka jawaabi karaan isticmaalka "salofalk" by xanuun caloosha, dibiro, shuban, lallabo, matag ah. horumarinta suurtogalka ah ee hepatitis, qiimaha transaminase cagaarshowga beddelo. nidaamka wadnaha-vascular heli kartaa tachycardia, is beddel cadaadiska dhiigga (barar aad ama hypotension), xabad xanuun, dyspnea.

Xaaladaha qaarkood, bukaanada la maqli karaa horumarinta myalgia, arthralgia. Intaa waxaa dheer, daroogada waxay keeni kartaa dhiig yari, leukopenia, Torombositobiiniya, anuria, oliguria, hematuria, crystalluria.

Of dhowr ah oo dareen diidmo oo xasaasiyadeed waxaa suurtagal ah cuncun, finan maqaarka ah, erythema, bronchospasm, pericarditis iyo myocarditis. In bukaanka qaba diidmo in mesalazine laga yaabaa in la horumariyo cudurada sida kelyo interstitial, nephrotic syndrome, marxaladda ba'an ee pankreatit. In koox gaar ah bukaanada "salofalk" (oo la mid ah uu sidoo) keena astaamo la mid ah syndrome ah lupus erythematosus oo nidaamsan.

daawooyinka analogues

The "salofalk" tiro ku filan oo daawooyinka analogues ah qayb weyn ee firfircoon. Sidee karaa, tusaale ahaan, bedelo "salofalk" - shumac? Analogues, taas oo inta badan ay yihiin danaha macaamiisha iyo bixiyayaasha daryeelka caafimaadka waxaa loo magacaabay - waa dabada "Pentas" iyo "Samezil". Daawooyinka Kuwani qayb weyn ee firfircoon yahay mesalazine, si ay u leeyihiin saamaynta pharmacological la midka ah ee jidhka bini'aadamka.

"Mesakol" - kale loo analog "salofalk" (ee dhagaxyada ah, kiniin).

Ka sokow qayb analog dhaqdhaqaaqa, waxaa jira kooxo badan oo daroogada oo la mid ah in saameyn ku daweyn. Daawooyinkan waxaa si ammaan ah ay qaban karaan "azathioprine" iyo "Alginatol", "hydrokortisoni" iyo "Dexamethasone" "Diprospan" iyo "Irmalaks", "prednisolone" iyo "Sulfasalazine". Liiska tagaa on.

talooyin gaar ah

Ka hor inta aadan bilaabin daawada iyo inta lagu jiro daaweynta iyo ka dib bixiyayaasha joojinta ay ku talinaynaa inay qaataan imtixaanada dhiigga iyo kaadida caadiga ah. Oo weliba intaan daaweynta iyo geedi socodka waxaa lagama maarmaan ah in lala socdo xuduudaha gobolka functional of beerka. Kormeerka waxaa sida ugu wanaagsan sameeyo 14 maalmood ka dib ka dib markii bilow ah therapy, ka dibna 2-3 jeer kale dura 4 todobaad. Haddii natiijada baaritaanka ay yihiin xadka caadiga ah, la socodka sahan fuliyay 3 biloodba mar. Haddii si lama filaan ah nooc ka mid ah weecasho lagu arkay doonaa falanqaynta, waxaa lagama maarmaan ah in si degdeg ah u fuliyaan tijaabooyin gacanta.

In magacaabista nooc kasta oo dawo "salofalk" (shumac, analogues kaniiniyada, dhagaxyada ah, ganaax) si ay bukaanka ka cabanaya neefta bronki, dhakhtarka ayaa loo baahan yahay in si taxadar leh ula socdaan xaalad ka mid ah bukaanka inta lagu jiro daaweynta. Haddii bukaanku leeyahay taariikh u muuqataa suurtagalnimada waxyeellooyinka marka la qaadanayo "Sulfasalazine" state of caafimaadka dadka sida waa in la soconayaa si taxadar leh in wajiga hore ee daaweynta "Salofalk." Haddii ay muujin ah cadaanyo ba'an dulqaad (gariir, calool xanuun, finan, qandho), isticmaalka daroogada waa in isla markiiba la joojiyo.

Marka aad wadid gaari ama fulinta shaqo u baahan in dareen diidmo psychomotor xawaaraha sare, bukaanlayda qaadato "salofalk", waa in aad u taxaddar.