Prednisolone: tilmaamaha loo isticmaalo, guryaha pharmacological

Release foomka "prednisolone" daroogada: foomamka, daawooyinka jilicsan - cadar.

Farmsvoystva

Prednisolone waa analoogga ah dehydrogenated of hydrokortisoni. Antiallergic, antiinflammatory, antiexudative iyo antipruritic saamayn marka loo isticmaalo dhayayo cadar "prednisolone" edbinta sababa hoos u dhac in formation, sii daayo iyo dhaqdhaqaaqa dhexdhexaadiyayaasha caabuq (kinin, histamine ah, falgalka lysosomal, prostaglandins). Sidoo kale socdaalka cell xanniban tahey in xuddunta bararka hoos u vasodilation oo kordhay permeability vascular in dhacdaa caabuq. Yaraynta maadoyinka waxaa sabab u ah tallaabo vasoconstrictor ah "prednisolone" daroogada. Buugga muujinaysaa in daroogada waa saamayn jirka by anada tallaabada of adag antigen antibody-iyo aruursaday on derbiyada marinnada dhiigga iyo sabab u yihiin vaskulitis xasaasiyad. Daawada hakiyo tallaabo ee macrophages, cytokines, unugyada diirada u keeni horumarinta nooca fal-celinta xasaasiyadda dermatitis qaadsiiyo. Sayidka wacyi T-limfosaytis iyo macrophages ma heli kartid unugyada bartilmaameedka.

Pharmacokinetics

Marka codsiga ah oo cadar "prednisolone" nuugo iyo walaxda firfircoon waa dhiigga. In prednisolone plasma dhiig qayb badan waa la xiriira in ay albumin iyo transcortin. prednisolone Biotransformation dhacdaa by qayilo, inta badan ee beerka, halkaas oo glucuronidation ama sulfation dhacdaa noocyo oxidized. In foomka of metabolites raaca ee kaadida iyo saxarada, qayb ka mid ah - in dawlad unmodified. Prednisolone maraa celiyaha mandheerta ku uruureen yar, waxaa laga heli karaa caanaha naaska ee dumarka.

Prednisolone: maragga

Daawada waxaa loo isticmaalaa in kiisaska ka mid ah:

- xasaasiyad iyo irritant dermatitis xiriir,

- cambaarta,

- dermatitis hidde ah,

- dermatitis seborrheic,

- psoriasis.

Prednisolone: edbinta

cadar waxaa laga dalbadaa in ay goobta boogta siman 1-3 jeer / maalintii. Duration daaweynta waxaa keena nooca cudurka iyo sida caadiga ah waxay qaadataa 8-14 maalmood. Waxay cadarkan in lagu daweeyo carruurta muddada daawaynta waa in la hoos u dhigay 3-7 maalmood, tan jirka ilmaha waa u nugul "prednisolone" daroogada. Waxbarashada talinaysaa ka tanaasulaan kululaaneysa, qamaar iyo Duubista occlusive.

Features of codsiga

Muddada aad daawada marisay waa in aanay noqon in ka badan 14 maalmood si looga hortago waxyeelo suurto gal ka isticmaalka "prednisolone" daroogada. Waxbarashada qoray si loo daaweeyo oo keliya ka yar kormeer caafimaad.

waxyeellooyin

Sida caadiga ah daroogada si fiican loo dulqaatay. Marar dhif ah, gaar ahaan isticmaalka daba dheeraaday ka dib, waxay keeni kartaa cuncun, dareen gubasho, erythema. In bukaanka qaar ka mid ah waxyeelo ka muujin karaa sida folliculitis, hypertrichosis, dermatitis perioral, dareen diidmo oo xasaasiyadeed in qaybaha daawo. Calaamadaha kor uma baahna daaweyn iyo si deg deg ah laga saaray garoonka la joojiyo oo codsiga of daroogada. Waa in la xusuustaa in codsiga ah oo cadar ku maqaarka saameysey iyo isticmaalka muddada-dheer (gaar ahaan guuldaradii ee qaybo badan oo maqaarka) ayaa laga yaabaa inuu waxyeelo dabiiciga ah systemic.

Isdhexgalka daawooyin kale

Prednisolone leeyahay hantida si kor loogu qaado saamaynta daawada xinjirowga lidka ku ah daawada xinjirowga. Waxay kordhisaa suurtagalnimada dhiig inta aad qaadanaysid salicylates. Waxay kordhisaa suurtagalnimada of xanuunada-shiid elektrolytka maamulka saameen ah diuretics. Ma jirto halis sii kordhaysa oo sumoobo marka la isticmaalayo glycosides wadnaha. Hoos u saamayn antidiabetic hypoglycemic iyo hoos u waxqabadka bakteeriyada ka mid ah rifampicin. Ma talinayo in la isticmaalo in lala laabjeexa.

sababo

Daaweynta "prednisolone" edbinta cadar waa ka mamnuuc in:

- diidmo,

- bakteeriyo, fayras, lesions maqaarka fangas;

- qaaxada, waraabow, burooyinka maqaarka, uurka, finan caadiga ah iyo finan casaan.

badinta

Kiisaska ah qiyaasta xad dhaafka yihiin oo aan la garaneyn.

xaaladaha kaydinta

Dhawray liiska B ah, at 5-15ºS. Shelf nolosha - 2 sano. At dhacayo ee nolosha shelf in aadan isticmaalin.

shuruudaha sahayda

Qoro.