"Moxifloxacin": tilmaamaha loo isticmaalo, sharaxaad, halabuurka

medicament The "Moxifloxacin" saamayn pharmacological kuwaas oo halkan laga wada hadli doonaa, waxa loola jeedaa koox ee quinolones. qalab waxay leedahay bactericidal ah, saamayn bakteeriyada. Next, aan ka wada hadalno waxa daawo "Moxifloxacin". Tilmaamaha loogu isticmaalo, analogues sidoo kale la soo bandhigi doonaa ee maqaalka.

saamaynta

Sidee waa wakiilka firfircoon "Moxifloxacin"? Description of daroogada waa in ay bilaabaan oo leh sharaxaad ka mid ah hab ay of ay saamayn on bakteeriyada. saamayn Bactericidal macnaheedu la xidhiidha Iscelin (xakamaynta) ee topoisomerase IV bakteeriyada iyo II. Tani, ka bacdi, waxay keenaysaa in rabshooyin in geedi socodka taranka ee qoraal ah, dayactir DNA biosynthesis unugyada microbial. Sidaas darteed, waxaa jira yimaado oo ay u halligmaan. Medicament "Moxifloxacin" diiwaanka sharaxayaa sida antibiotic ah spectrum ballaadhan.

caabin

On waxqabadka bakteeriyada daroogada "Moxifloxacin" wax saameyn ah kuma habab in ka cadhaysiinina iska caabin ah ay u tetracycline'nada, macrolides, aminoglycosides, cephalosporins iyo benisiliinta. Waxa aan si fiican loo muujiyey iyo saamaynta cross-caabin ah. Ilaa iyo hadda, xaaladood oo xasilooni plasma aan la aqoonsaday. adkeysiga daawada "Moxifloxacin" horumarinta ilaa xad si tartiib ah by Isbedelo badan.

kala duwan oo ka mid ah hawlaha

Oo macnaheedu yahay "Moxifloxacin (diiwaanka - caddayn) saameeyaa nooc badan oo bakteeriyada Gram-positive iyo Gram-negative, bakteeriyada acid-degdeg ah, anaerobes, sheyga atypical (mycoplasma, chlamydia, iwm), iyo sidoo kale bakteeriyada in ay yihiin adkaysi u macrolide iyo beta-lactam daroogada antibiotic .

nuugid

Marka la helo nuugista afka daroogada "Moxifloxacin" deg deg ah oo ku dhow dhamaystiran. bioavailability Absolute markii intravenously maamulo iyo codsanaya duuban - amarka of 91%. Marka hadal ahaan maamulo (50-1200 dose mg, 600 mg / maalintiiba muddo 10 maalmood) pharmacokinetics toosan ee daroogada. fiirsashada ugu badan la 400 mg arkay 0.5-4 saacadood ka dib. Marka mar codsatay cunto gaaro in la kordhiyo muddada muddada Cmax (laba saacadood) oo ay hoos u dhacay illaa 16%. nuugista Duration sidaas isma badelin. Si kastaba ha ahaatee, xogta, kuwaas oo aan haysan qiimaha caafimaad oo kuu ogolaanaya in isticmaalka daroogada "Moxifloxacin", iyadoo aan loo eegin cuntada. Ka dib markii faleebo hal faleebo of 400 mg for fiirsashada saac ugu badnaan dhaco dhamaadka galiyey.

qaybinta

saddex maalmood codsiga gudahood lagu gaadhay hoganaya. Qabanaya borotiinka plasma - oo ku saabsan 45%. Waxaa Hagidda qaybinta si caddaalad ah oo degdeg ah oo daroogada ah xubnaha "Moxifloxacin" iyo unugyada. uruureen ugu sarreeya waa in unugyada sambabada iyo duufka hawomareenno, maqaarka iyo subcutaneous dhismayaasha, hogaga, iyo Axdigu bararka. The candhuufta iyo medicament dheecaan interstitial waxaa laga helaa borotiinka furan, qaab xor ah. Its fiirsashada uu ka badan yahay in plasma. Wada jir ah ula daroogada this waxaa laga helaa xaddi badan ee xubnaha xubnaha taranka unugyada peritoneum dumar iyo dheecaanka xuubka hoose.

dheef-

Daawo "Moxifloxacin" (sharaxaad ka mid ah daroogada ee xogta annotation wuxuu ka kooban yahay macluumaad) maraa wajiga biotransformation labaad. nidaamka Digo fulin Kelyaha iyo xiidmaha oon doorsoomaynin foomka xeryahooda sulpho iyo glucuronide firfircoonayn. metabolites waxaa laga helaa plasma. Ay fiirsashada hoose ka badan in ka mid ah xarunta asalka ah. Daraasado ayaa muujiyey in badeecooyinka loo gaysto kuwaas oo aan haysan saamayn xun oo jidhka ah.

Oo macnaheedu yahay "Moxifloxacin", kaas oo waxaa la qoray?

Daawada waxaa lagu talinayaa in heley bararka faafa ee dadka waaweyn xanaajiyeen by sheyga isagoo dareen ku daraa. Gaar ahaan, akhrinta ee la xidhiidha sii daridda ah ee socodka boronkiito daran, hogaga ba'an, pneumonia bulshada helay (sababa nooc ka mid ah bakteeriyada soo bandhigista iska caabin kala duwan ee ka H. antibiotic The t.). Oo macnaheedu yahay "Moxifloxacin" tilmaamaha loo isticmaalo lagula talinayaa cudurada of unug jilicsan iyo maqaarka, dhismayaasha subcutaneous adag lesions (cudurka cagta diabetic sidoo), iyo cudurada intra-caloosha (geedi socodka polymorphic, bax intraperitoneal sidaas). Waxa lagu qoray markii medicament ka Streptococcus pneumoniae adkaysi u antibacterials badan, oo ay ku jiraan joogitaanka nooc adkaysi u penicillin, laba ama in ka badan kooxaha daroogada of labaad cephalosporins Qarni, macrolides, tetracycline'nada. By muujinaya sidoo kale waxaa ka mid ah lesions bararka ee xubnaha miskaha nooca aan xumayn. Marka endometritis iyo salpingitis ayaa sidoo kale lagu dhiirigelinayaa inay tixgeliyaan hab ah (sida lagu muujiyey by tilmaamaha ku lifaaqan daroogada "Moxifloxacin" si loogu isticmaalo). dhibco lagu shubo indhaha loogu conjunctivitis bakteeriyada, xanaajiyeen by sheyga xasaasi u ah medicament ah. Waxa kale oo lagama maarmaan ah inay tixgeliyaan daaweynta jira hoggaanka heley faafa.

Medicament "Moxifloxacin": ku qiyaasta iyo wadada maamulka

Funds duuban (oo afka ah) iyo intravenously loo qoondeeyey. . Duration daaweynta medicament ah "Moxifloxacin", qiyaasta kuwaas oo - 400 mg / maalintii, iyada oo ku xidhan nooca cudurka iyo adkaanta, iyo sidoo kale saamaynta ay ku daweyn arkay:

• Daridda dabcan boronkiito daran - 5-10 maalmood.
• 7-14 maalmood therapy isku xig xiga (xididka raacay by qaadashada afka) - pneumonia Community-heleen.
• unugyada jilicsan, maqaarka (badnayn), iyo hogaga ba'an - 7 maalmood.
• Marka caabuqyada intra-caloosha (adag) - 5-14 maalmood therapy isku xig xiga.
• Marka adag lesions iyo dhismayaasha subcutaneous maqaarka - 7-21 maalmood.
• In heley bararka oo ka mid ah xubnaha miskaha - 14 maalmood.

Wixii macluumaad dheeraad ah, ku jira lifaaqan "Moxifloxacin" Buuggan daroogada edbinta. Kiniiniyada waa in aan loo oggolaan in calaliyo. Dhaq hoos biyo loo baahan yahay in mugga yar.

isticmaalka degaanka

Daawo "Moxifloxacin" (dhibcood) ayaa laga yaabaa in la siiyo bukaanka by sanadka. Practice muujinaysaa in horumar uu ka yimaado maalintii shanaad. Ka dib markii in aad waa in ay sii wadaan daaweyn 2-3 maalmood oo kale. Bukaan-socodka isha ay dhibaatadu saameysey Ruhbaaniyad dhibic saddex jeer maalintii. Haddii ay jirto wax saamayn ah muddo shan maalmood ah waa in kor su'aasha ah ee sax ah therapy ama cudurka. Muddada aad daawada ku xiran koorsada bakteeriyadda iyo kiliinikada iyo adkaanta cudurada ka.

Dheeraad ah oo ku saabsan xal faleebo

Buugga Medicament "Moxifloxacin" edbinta ku talinaysaa in aad soo gashid saacad. Daawada sidaas noqon kartaa in undiluted ama qaab la badhxay. Xalku waa la jaan chloride sodium 0.9%, biyo la isku duro, xal dextrose at uruuray of 10% iyo 40%, 20% xylitol, "ringer". Isticmaal cabitaanno cad oo keliya. Ka dib markii Barxo of medicament weli deggan maalmo heerkulka qolka. Waa in aan la hayaa hab qaboojiyaha. Haddii galiyey loo maamulo la wakiilada kale, kuwaasoo mid walba uu goonidiisa loo.

waxyeellooyin

Maaddaama ay daawo daaweynta "Moxifloxacin" tahay in cudurada fangas, leukopenia, dhiig yari, Torombositobiiniya. Xaaladaha qaarkood, daawaynta ku jirto in la kordhiyo waqtiga prothrombin, uruureen thromboplastin beddelo. In bukaanka qaar ka mid ah daroogada waxay keeni kartaa dareen diidmo oo xasaasiyadeed, barar doobta, urtikaria, shoog, pruritus, eosinophilia, finan. Marar dhif ah, waxaa jira hyperglycemia, hyperlipidemia, hyperuricemia. In daaweynta xanuunada dhimirka tahay. Gaar ahaan, bukaanka la kulmi karaan fawdada ah, walaaca, niyad-jab, udagaashaa, dhalanteed, reactions waallida, oo ay la socdaan fikradaha isdilka. Waxyeelooyinka ugu badan waxa ka mid ah madax xanuun, wareer, gariir, hurdo, wareer, xanuunada dareenka dhadhanka, rabshooyin hurdo, jaahwareer. Mararka qaar, inta lagu guda jiro daawaynta daawada adkaanaysaa laga yaabaa in isuduwidda, qalal, Ulasocto daliilka kiliinikada kala duwan, hypoesthesia, disorder ee dareenka urta. Tiro ka mid ah bukaannada ku lahaa sii xumaanaysa hadalka, dareenka, neuropathy durugsan, xusuus la'aan, polyneuropathy ah. Marka laga dhayayo codsatay, aragga hoos u dhici karta ilaa ay soo gaartay. Si kastaba ha ahaatee, tan dambe ayaa waxaa loo arkaa inay xaalad transient.

Saameynta nidaamka wadnaha

Qayb ka mid ah saamaynta codsiga ah ee daroogada "Moxifloxacin" waa Dheereyn ku QT-bareeg in bukaanka qaba hypokalemia, uurkuna waa, vasodilation, tachycardia. Waxyeellooyinka naadirka ah waxaa ka mid ah dhiig-karka iyo hypotension, tachyarrhythmias ventricular, syncope. Waxa aad u dhif arkay wadnaha. Socon inta badan caadi ah oo loogu talagalay dadka hiddaha ischemia ba'an, bradycardia (Caafimaad ahaan la taaban karo).

Impact on nidaamyada kale iyo xubnaha

Xaaladaha qaarkood, daroogada waxay keeni kartaa neefta oo ku qabata, oo ay ku jiraan xaalad neef. Tiro ka mid ah bukaannada ayaa lagu arkay xanuunada jirta marinka dheef shiidka. Gaar ahaan, dhanka ah asalka ah lallabo daaweynta degdegga, matag, shuban, calool xanuun. Xad waxyeellooyin yar waxaa loo arkaa cunto xumo, dyspepsia, yaaqyaaqsi, caloosha (marka laga reebo erosive), caloosha oo. Bukaanjiifka qaar ayaa loo aqoonsaday stomatitis, dysphagia, ulcerös pseudomembranous. therapy waxay u badan tahay sii korodhsan doonaa transaminases, cillad cagaarshowga, horumarinta hepatitis fulminant, failure cagaarshowga taasoo keentay in naf-gooyada ah. Waxa aad u dhif arkay reactions cutaneous bullous (necrolysis epidermal sun ah, Stevens-Johnson syndrome). Bukaanjiifka qaar ayaa la kulantay myalgia, arthralgia, gariir, kor u cabirida xaalada muruqa, gaaray bowdada, tabar-dari muruq. goydey seed ku dhici kara Marar dhif ah, arthritis, qas wiiqmin sabab u ah burburka nidaamka muruqyada. Bukaan-socodka daaweynta daawada kale oo ay noqon kartaa xanuunada la fiirsanayo nidaamka kaadida. Gaar ahaan, calaamadeeyay (shuban ka xanaajisay ama hoos u dhac ku mugga dareeraha baabbi'iyey) fuuqbaxa, cillad kelyaha, la'aan. Waxyeelooyinka ugu badan waxa ka mid ah dhidid, xanuun nonspecific, qidmeyntii. In thrombophlebitis ee xididka tahay ama phlebitis.

Yaa lagu qorin tahay?

In daawada sababo "Moxifloxacin" waa sida soo socota:

• cudurada seed taariikhda in la horumariyo sabab u ah kooxda antibiotics quinolone therapy.
• Helitaanka elongate QT-bareeg (dhasho ama helay).
• rabshooyin elektrolytka (gaar ahaan hypokalemia la saxin).
• Bradycardia (Caafimaad ahaan la taaban karo).
• Heart failure la function ejection hoos ku ventricle bidix.
• Xadgudubyada garaaca wadnaha (taariikhda).

Marka lactose, nuugeynin glucose-galactose, deficiency lactase waxaa sidoo kale aan lagu talinayaa in medicament "Moxifloxacin" (Halabuurka daroogada ka kooban lactose, oo sidaas daraaddeed heley ku xusan waxaa lagu soo daray liiska). Ma loo xilsaaray macnaheedu uurka leh ama nuujinaya. Kiniiniyada iyo xal ayaa loo ogolaaday inuu bukaan caga 18 sano jir. daroogada lagu talinayo in ay dhacdo diidmo in qaybaha u.

xaalado gaar ah

Digniin loo baahan yahay in magacaabidda daroogada si uu bukaanka qaba cilladaha habdhiska dhexe in kudhacaan horumarinta qalal. kooxda halista waxaa ka mid ah bukaannada qaba dalalka proarrhythmic. Waxaa ka mid ah, gaar ahaan, waxaa ka mid ah ischemia ba'an, gaar ahaan dadka waayeelka ah iyo haweenka. Sidoo kale dhawrtaan oo digniin bukaanka qaba beerka cirrhosis. sixitaanka qiyaasta loo baahan karaa inta lagu jiro hab waafaqsan therapy hoos fiirsashada of potassium.

Wixii macluumaad dheeraad ah,

Practice muujinaysaa in daawada si fiican loo dulqaatay in dad badan oo buka. Khubaro badanaa qori qalab loogu lesions faafa. Tan waxa u sabab xaqiiqada ah in daroogada ayaa wax ku oolnimada a xad sare oo ah bakteeriyada badan. Si kastaba ha ahaatee, waxaa had iyo jeer waa halista waxyeellooyinka, kuwaas oo ka mid ahaa la soo saarka oo ka digtay "Moxifloxacin" diiwaanka. Analogs daroogada ee case of baahida loo qabo waa soo qaado dhakhtarka si gaar ah. Beddel qalab daroogada kartaan sida: "Avelox", "Vigamoks", "Rotomoks", "Moksifur", "Moksin" iyo kuwa kale. Marka saamaynta xun, sii daraysa af iyo dhacdo ka mid ah calaamadaha aan ku tilmaamay in kooban, waa inaad raadsataa daryeel caafimaad oo degdeg ah. Marka la isticmaalayo dhibcood waa inay ka fogaadaan xiriir la xaddi dhaafka ah ee indhaha daroogada ee. Haddii ay taasi dhacdo, aad sida ugu dhaqsaha badan u baahan tahay la biyo fara badan. In case of gol leeyahay xad dhaafka ah waxyeelo.

Gebogebadii

Daawada "Moxifloxacin" tixgeliyo bakteeriyada ku filan awood. In xidhiidh la leh this aad u ma waxaa lagu talinayaa in ay jebiyaan warqad dhakhtar ee. Gaar ahaan, waxa ay ku saabsan tahay tirada iyo inta jeer ee hab codsiga. Ha ka badan qiyaasta. duridda xididdaha waa in la fuliyaa ee waxbarasho gaar ah xubin shaqaale ah oo tababar si ay u caawiyaan haddii loo baahdo awood u yeelan doonaan. ma aha in ay is-Dawada Waxaad. Maqnaanshaha natiijooyinka daaweynta loo baahan yahay inaad aragto dhakhtar. Just ka hor si ay u isticmaalaan daroogada "Moxifloxacin" Waa in si taxadar leh u akhri tilmaamaha.