"Mirapex": tilmaamaha loo isticmaalo, sharaxaad, dib u eegista

In article waxaad ku baran doontaa dhammaan ku saabsan diyaarinta "mirapex" ah: sida loo bedelo daroogada this, waxa saamayn, sababo, waxyeelo, tilmaamo gaar ah ay gacanta ugu. kaniiniyada waxay keeni karaan dabeecad aan caadi ahayn iyo raadka ay ku leeyihiin wax ka qabashada bukaanka. Sidaa darteed, ka hor inta aad qaadanaysid dawadan tilmaamaha "mirapex" si loogu isticmaalo waa in si taxadir leh loo soo bartay. Waxa kale oo aanu kuu sheegi ah oo ku saabsan waafaqid oo ka mid ah kaniiniyada daawooyin kale.

Sii dheerayn "mirapex": warbixin guud oo ku saabsan daroogada iyo tilmaamo loogu isticmaalo

walaxda firfircoon ee diyaarinta "mirapex" waa pramipexole. Kiniiniga darran qaybood: povidone, mannitol, istaarijka, aerosil, milmahayn magnesium.

Daaweynta daroogada this waxaa lagu fuliyaa idiopathic (madax banaan lesions kale) syndrome ee "lugaha baaxaa" iyo cudurka Parkinson iyo sidoo kale baabuurta kale la safeeyey iyo cudura extrapyramidal.

Product: kiniinka "XPIEIV mirapex" 3 mg, 4.5 mg, 1.5 mg, 0.75 mg, 0,375 mg. Waxaa loo buuxiyey oo ku yaal finan of 10 xabbadood, ka dibna kartoonada.

kaniiniga cad. Waxay leeyihiin qarkiisa ah beveled iyo qaab guri labada dhinac, mid ka mid ah taas oo uu leeyahay halista qoto dheer.

Kiniiniyada waa in la qaato afka, iyadoo aan loo eegin cuntada. Cun daroogada la oggol yahay waqti kasta. Xaaladdan oo kale, waa in la hoos u maydhay biyo. dose maalin walba lagu talinayo u qaybsan yahay saddex marxaladood.

hab ay of action (pharmacodynamics) Kiniiniga "mirapex"

walax pramipexole wax ku ool ah oo ka kooban diyaarinta "mirapex" si gaar ah iyo la selectivity sare wanaajisaa jawaab u ah koox hoosaadka ee receptors dopamine D2. Thanks isaga si, magdhawo la'aanta ah ee dhaqdhaqaaqa jirka in ay dhacdo cudurka Parkinson. Tan waxa u sabab ay hawshooda u soo dhaweeyayaasha dopamine in striatum ah. Sayidka pramipexole ka hortagtaa xumaanshaha ee neurons in dhacaa sabab u neurotoxicity ama ischemia. Waxa uu hakiyo ama yaraynaysaa heerka of Avv, shiid, iyo sii daayo dopamine. Thanks to neurons pramipexole laga badbaadiyo saamaynta sun ah anti-Parkinson wakiilada "Levodopa". Sidoo kale sabab u tahay saamaynta hoos u prolactin (dose-tiirsane ah).

In the case of isticmaalka daba dheeraaday ee kaniiniga "mirapex" oo lagu daweeyo cudurka Parkinson (in ka badan saddex sano) iyo syndrome ee "lugaha baaxaa" (in ka badan sanad a) ma muujin hufnaan hoos pramipexole.

geeddi socodka lagmamaarmaanna ku lug leh diyaarinta "mirapex 'in jirka bukaanka (pharmacokinetics)

walax Active "mirapex" daroogada si buuxda iyo si degdeg ah nuugo ka dib markii maamulka afka. Isaga oo awood u milmaan (bioavailability) waa ku dhawaad buuxda - in ka badan 90%. fiirsashada ugu badan ee daroogada ee plasma arkay 1-3 saacadood ka dib marka aad wax cuntid. At cuntada heerka nuugista pramipexole hoos. Xaaladdan oo kale, xaddiga cuntada digestible ma beddelmin.

borotiinada C xidhana pramipexole yar (ka yar 20%). Waxay leedahay mugga weyn qaybinta - 400 litir, taasoo ka dhigan in fiirsashada ee dhiigga ku jira oo hooseeya. Ilaa xad yar bandhigi habka dheef daroogada. Qiyaastii 90% qiyaasta kaabsal "mirapex" saxarrada kelyaha, iyadoo 80% - beddelin. The pramipexole saxarada laga helo qadar ka yar 2% lacagta ku baabba'saday of daroogada. Cadka ama dheecaannada jidhka waxaa lagu nadiifiyaa ka kiniin "mirapex" heerka celcelis ahaan 500 ml / min.

Isticmaalka "mirapex" daroogada inta aad uurka leedahay

Ma isticmaali karaa inta ay uurka leedahay "mirapex" kiniin? Tilmaamaha isticmaalka daroogada ka dhigaysa cadeeyay in saamaynta daroogada ku saabsan horumarinta ilmaha caloosha ku jira uurkii iyo nuujinta, aan la baarayaa.

Saamaynta suurto galka ah ee pramipexole on nidaamka iyo maamulka ayaa masuul ka ah geeddi-socodka iyo dheddiga ah ayaa la bartay in tijaabo on xayawaanka. Waxa aanu mariyo xadgudubyada horumarinta uurjiifka inta aad uurka leedahay ee bakaylaha iyo jiirka.

Digo ee pramipexole caanaha naaska aan la bartay. Mid ka mid ah u qaadan kartaa oo keliya in walaxda la xakameeyo kartaa nuujinta, tan wax soo saarka uu hakiyo hormone luteotrophic. Sidaa darteed, ha qaadan "mirapex" pill inta lagu jiro naas-nuujinta.

Inta aad uurka leedahay, daroogada waa in la qaato kaliya haddii lacagta laga yaabo in hooyada weyn naefigooda, khatarta mustaqbalka in ay ilmaha caloosha ku.

Sababo isticmaalka mirapex kiniiniyada ' "

Drug "mirapex" ma loo qaadan karaa in ay dhacdo diidmo in pramipexole, iyo sidoo kale dadka aan gaaray 18 jir.

Iyada oo digniin gaar ah waxaa lagula talinayaa in ay isticmaalaan kaniiniga cadaadis dhiig oo yaraadey iyo kelyaha.

Dhibaatooyinka ay keento "mirapex" daroogada on habka dareemayaasha

Diyaarinta "mirapex" - kiniin taasoo keeni karta habka dareemayaasha jirka soo socda falcelin:

• wareer;
• damacsanaayeen intay xad-dhaaf ah, waayo, hurdo la'aanta oo dhan;
• dhalanteed;
• xusuus la'aan;
• asthenia;
• wareer;
• syndrome extrapyramidal;
• hypoesthesia;
• gariirka,
• myoclonus;
• dystonia;
• niyad-jabka,
• delirium;
• fikirka is dilka,
• hypokinesia;
• ataxia;
• walaaca,
• neuroleptic syndrome malignant.

Last arkay qaab hyperthermia, rabshooyin miyir iyo fikirka, rigidity muruqa, lability autonomic, akathisia.

Dhibaatooyinka ay keento kiniinka "mirapex" on hababka kale ee jirka aadanaha

Nidaamka muruqyada jawaabi karaan isticmaalka daawooyinka "mirapex" daliilka sida:

• muruqyada hypertonic, gariir ay, shimbirka;
• dhacdo of arthritis, daweeyay gravis ama bursitis;
• xanuunka xabadka, qoorta ama lafdhabarta (in lumbosacral ah).

Waxay kaloo ku dhici kartaa kala duwanaansho ee habka dheef shiidka. Marka ay taasi dhacdo,

• rabitaanka cuntada oo luma;
• calool;
• lalabo,
• dyspepsia;
• yaaqyaaqsi,
• shuban;
• matag,
• afka oo qalala,
• jarida dareen in caloosha.

soo dhaweynta "mirapex" Respiratory daroogada waxay keeni kartaa in horumarka hogaga, pharyngitis, rhinitt, hargab oo kale syndrome. Sidoo kale waa dhacdo suurto gal ah neefta oo ku qabata, qufac kordhay iyo isbedel cod.

Waa maxay saamaynta ku saabsan nidaamka "mirapex" kiniinka wadnaha? Tilmaamaha loogu isticmaalo daroogada wargelinaysaa ku saabsan suurto gal tachycardia horumarinta, arrhythmia, kog, hypotension orthostatic.

Saameynada kale ee dhinac

Marka helo "mirapex" daroogada dhibaatooyin kale ku dhici kara nidaamka Fistula, sida inta badan soo noqnoqda saxarada, cudurka. Sayidka xitaa u maleeyeen khasaaro of libido iyo awoodba.

Intaa waxaa dheer, waxaad la kulmi kartaa riyadii labanlaab, cataract, conjunctivitis, curyaannimo hoyga, xasaasiyad, iyo maqalka, cadaadiska intraocular.

Dareen-celinta kale ee loo kasin ee jidhka:

• cystic retroperitoneal;
• effusion pleural;
• dhexgalka pulmonary;
• miisaanka oo yaraada;
• bararka durugsan.

Qiyaasta iyo Maamulka Kiniiniga "mirapex"

Si aad u isticmaasho daawada aad u baahan tahay gudaha, maalin kasta 3 jeer. dose kiniin Xarafka "XPIEIV mirapex" - 0,375 mg maalintii. Tartiib ah u kordhi xaddiga daroogada loo baahan yahay (7 maalmood oo kasta) si ay u helaan saamayn la doonayo daweynta. In toddobaadka labaad ee daawaynta maalin kasta waa la wada baabbi'in by 0.75 mg saddexaad - in 1,5 mg waayo, kii afraadna wuxuu ahaa - by 2.25 mg u baahan shanaad daawo "mirapex" in aad cabto 3 mg maalin kasta, on lixaad - 3.75 mg, toddobaad - 4.5 mg.

In renal failure raaga, qiyaasta la beddelo oo ku salaysan heerka waxqabadka ansixin kariyaatiniin ah. tirada saxda ah ee daroogada waa in la magacaabay dhakhtar.

Cawaaqibta pill badinta "mirapex"

Haddii aad isticmaasho "mirapex" qiyaasta daawada ahayd la jebiyey, calaamadahan dhici kara ineey dhalanteed, hyperkinesia, lallabo, matag, hoos u cadaadiska dhiigga iyo kacsiga.

Waayo, xaaladda this, daawo aan la rakibay. Kiisaska of badinta daroogada "mirapex" aan go'an. therapy talinayo astaamaha, lavage gastric iyo dhawrid firfircoon. Haddii ay jiraan calaamado ah qiyaasta xad dhaafka ah ee excitation of habka dhexe ee neerfayaasha, waxaa lagama maarmaan ah in aad dalbato diyaar, neuroleptics.

Isdhexgalka kiniin "mirapex" daawooyin kale

Pramipexole la xidhiidha wax yar protein plasma iyo biotransformation. Sidaa darteed, ay la macaamilaan daawooyinka kale ee saamayn ku yeelan geedi socodka kuwanu waa lagama yaabo.

Daroogooyinka oo la xakameeyo ama loo xakameeyo soo saarka ee walxaha firfircoon ama samovyvodyaschiesya cationic iyada oo tubules kelyaha, fal karaa kiniinka "mirapex". Tilmaamaha loogu isticmaalo in ay dhacdo in this hoos xawaaraha unugyada cad daahirintiisa iyo dheecaannada dhalay ama labada medicaments ama mid iyaga ka mid ah.

Haddii isku mar la mirapex kaniiniyaal ' "loo isticmaalo daroogada, kuwaas oo, waa in aad lacag bixisid si aad u muuq suurto gal ah, Tardive, cadhoodaan dareenka. Haddii calaamadaha dhacaan, qiyaasta daawada waa in la dhimay.

kiniiniyada waafaqsan "mirapex" daawooyin "Amantadine" iyo "L-dopa"

Maxaa dhacaya marka ay soo dhaweynta "Levodopa" daawooyin la isku daro iyo kiniiniga "selegiline" "XPIEIV mirapex"? Waxbarashada sheegayaa in pharmacokinetics of wakiilka firfircoon waxba uma dhimeyso mana ugu horeysay mana labaad. Isla mar ahaantaana on milmaan buuxa iyo Digo of daroogada ee hab dabiici ah "Levodopa" kiniin "mirapex" aan la aqoonsan yahay.

Pramipexole lama bartay dhexgalka ee daroogada "Amantadine" ah. Laakiin waafaqid waa suurto gal in therapy, tan iyo markii ay leeyihiin habab la mid ah Digo.

Marka qiyaasta "mirapex" diyaarinta kordhay, lacagta codsiga "Levodopa" talinayaa in ay yaraadaan. Tirada daroogooyinka kale antiparkinsonian waa in si joogto ah loo dayactiro heer la mid ah.

Maqaallo Dhignaashada diyaarinta "mirapex" daawooyin kale

Sababo la xiriira suuragalnimada in saameynta isbiirsatey si taxadar leh u daran waxaa lagu talinayaa in la isticmaalo kiniin "mirapex" isku dhafan oo daawada dajiyaha, khamriga, iyo daroogada oo kaa caawin in ay kordhiyaan fiirsashada pramipexole ee dhiigga (tus, a daroogada "cimetidine").

hanuun gaarka ah ee isticmaalka kiniiniyada "mirapex"

Waxaan ku tilmaamay daroogada laguma talinayo in ay qaataan in lala jirada dhimirka.

In daaweynta agonist dopamine waxyeelo loo yaqaan waa wareer iyo dhalanteed. Xaaladaha kaniiniyada "mirapex" isku dhafan oo daroogada "Levodopa" aan caadi ahayn sida ay ahaayeen inta badan soo noqnoqda ee marxaladaha ugu dambeeya ee uu cudurku ka badan in monotherapy hore.

dhakhtarka waa in ay wargeliyaan bukaanka ah dhacdo suurto galka ah ee muuq. Tani waxay saamayn dhinaca waxyeesha awooda inuu kaxeeyo oo go'aamo ka mas'uul.

In joojiyo fiiqan ee kiniiniyada in ay dhacdo cudurka Parkinson ayaa la ogaado muuqaalka kore ee calaamadaha u eg neuroleptic syndrome malignant.

dhaqanka Anomalous in isticmaalka "mirapex" daroogada

Bukaan-socodka iyo kuwa daryeelaya iyaga u, waxaa lagama maarmaan ah in la ogaado in soo dhaweynta ah ee daroogada dopaminergic, oo ay ku jiraan kiniinno "mirapex" (dib u eegista this xaqiijin), inta badan keena dabeecad aan caadi ahayn ee bukaanka. Waxaad la kulmi kartaa hyperphagia (qabatinka cunid), shopping bahal (doonayay waswaaska si ay u sameeyaan wax badan oo gadashada), khamaarka khasban waxaana hypersexuality. Xaaladaha noocaas ah waxaa lagama maarmaan ah in la yareeyo qiyaasta daawada ama si tartiib ah u joojiya eyniga.

Digniin ee isticmaalka kiniiniyada "mirapex"

Daawo "mirapex" waa la wada baabbi'in si taxadir leh in bukaanka qaba jiritaanka cudurro daran nidaamka wadnaha. In qabashada therapy daawooyin dopaminergic waxaa jira halis of hypotension orthostatic. Sidaa darteed, ay gacanta ku cadaadiska dhiigga ah, gaar ahaan bilowga hore ee daaweynta.

Marka aragga oo lagama maarmaan ah in si joogto ah isla markiiba loo hubiyo ka dib markii magacaabidda kiniin "mirapex" iyo dura sii qeexay.

Bukaan-socodka waa in la siiyo xaqiiqada ah in daawada waxaa laga yaabaa in saamayn ku dejinaysaa. Waxaa jiray kiis oo hurdo lama filaan ah iyo hurdo xad-dhaaf ah inta lagu jiro maalintii si ay hawlaha maalintii. this oo ay ku jiraan laga yaabaa inuu dhaco waqti walba ee maamulka mishiino adag ama baabuur-wadidda.

Suurtagalnimada ee melanoma soo koraya

Sidaas darteed waxbarashada epidemioligal ayaa muujisay in dadka qaba cudurka Parkinson ayaa halis ugu jira melanoma. Ma sababta cudurkan, ama arrimo kale, sida isticmaalka "mirapex" daroogada aan la aasaasay.

Xoojinta of syndrome ee "lugaha baaxaa"

Sidee syndrome ee "lugaha baaxaa" daroogada "mirapex"? Kurtumm muujinaya in daroogo dopaminergic waxaa kor loogu qaado laga yaabaa. Tan waxaa loo muujiyey in foomka of bilawga hore ee calaamadaha ee syndrome fiidkii iyo mararka qaarkood galabtii. Xaaladdan oo kale, calaamadaha faafay addimada kale. The qabtay 26 asbuuc daraasad caafimaad oo gacanta ku, kaas oo loogu talagalay in ay wax ka barato saamayn this, farqi weyn oo u dhexeeya kooxaha pramipexole iyo jaallaha ah ee kor muuqaalada syndrome ayaa loo aqoonsaday.

xaaladaha Kaydinta iyo nolosha shelf

"Mirapex" kiniin loola jeedaa diyaarinta ah B. Store liiska ay noqon waa meel gudcur ah. Xaaladdan oo kale heerkulka qolka waa in aanay ka badnaan 30 ° C.

Shelf-nolosha ee daroogada - 36 bilood (3 sano) laga bilaabo taariikhda of-soo-saarka.

Isticmaalka kiniin "mirapex" ee carruurnimada iyo xaaladaha heshiiska waxiibsashada

Daawada waa u in loo isticmaalo carruurta. Ogolaansho la siiyo dadka qaata kiniin, kaas oo gaadhay da'da 18 sano. Daawo "mirapex" daayay farmasiyada on bandhigga qoro.

analogues Drug "mirapex"

Waxaad ma, sababtu wax kasta, si ay u bartaan karaa kiniinka waa "mirapex"? Maxaa bedeli karo daroogada, waa inaad u sheegtaa shaqaalaha farmasiiga ama dhakhtarka. Oo waxaan ku siin ah analogues soo socda.

1. kiniinka "Motopram". Tilmaamayaasha loogu isticmaalo: cudurka Parkinson. Waxaa la samayn karaa oo keliya ama ay weheliso 'levodopa' daawo daawo. Waxaa sidoo kale loo isticmaalaa foomka idiopathic daran ama dhexdhexaad ah syndrome ee "lugaha baaxaa".
2. kiniinka "Oprimeya". Ujeeddo: kiciya oo dawo loo gudbiyo dopaminergic antiparkinsonian in habka dhexe ee neerfayaasha.
3. kiniinka "Pramipexole". Wakiilka daweynta loo isticmaalo cudurka Parkinson. Waxaa la rumeysan yahay in hab ay of action waxaa si toos ah loola xiriirinayay in ay awoodda pramipexole walax kicin receptors dopamine in striatum ah.

Kiniiniga "mirapex" - analogues ama asalka ah? No is!

In wax soo saarka kor ku xusan, kuwaas oo analogues kaniiniyada 'mirapex ". Waxay leeyihiin gaar ah, isku magaca caalamiga ah non-lahaansho (ama ATC-code), taasoo lagu taliyey by WHO (Ururka Caafimaadka Adduunka).

Haddii aad u baahan tahay inaad ku mari daaweyn qaadashada kiniinka "mirapex" analogs ayaa sidoo kale noqon karta hab weyn. Laakiin ka hor inta aad bedelo habka loo amray ee therapy, hubi inaad takhasus u leh la tasho. Under xaaladaha ma aan samayn is! Tani waxay sababi kartaa cawaaqib xun karin u ah caafimaadkaaga.

Digniin! article Tani waa sharaxaad ku saabsan "mirapex" diyaarinta waxaa kaabaya iyo fududeeyey version of tilmaamaha si rasmi ah loo isticmaalo. macluumaadka daroogada la soo bandhigay ujeeddo ah dib u eegis. Xaaladdan oo kale ma ma ay hage u isticmaalaan si ay is-daawo.