"Fosinopril": tilmaamaha loo isticmaalo. "Fosinopril": muujinaya in loo isticmaalo, dhigooda dhabta ah

"Fosinopril" waa inhibitor ah angiotensin enzyme diinta. daroogada ayaa tallaabo hypotensive, waxaa loo isticmaali karaa dhiig kar sare, oo keliya iyo in therapy adag. Intaas waxaa sii dheer, medicament ku fulyo natriuretic, vasodilating iyo ficil cardioprotective, waxaa loo isticmaalaa in lagu daro daroogada kale inta lagu guda jiro daaweynta wadnaha oo shaqadiisa gaba.

guryaha pharmacological "fosinopril"

Diyaarinta "Fosinopril" ee jirka ku qaadataa foomka of metabolite firfircoon in laga diiqadoodo saamayn on angiotensin enzyme diinta. Daawada yaraynaysaa heerka of formation of angiotensin 2, normalizes cadaadiska dhiigga ee systemic, saamayn togan ku xididdada dhiigga.

Angiotensin diinta hawl enzyme la isticmaalayo 10, 20 iyo 40 daroogada mg waxaa ku ool ah hoos u celcelis ahaan ilaa 7 saacadood (ma ka dhaqso badan 2 saacadood, laakiin aan ka dambayn 12 saacadood ka dib qaadashada daawada). Inta lagu jiro maalinta la dhimay by 7-15%.

Kiniiniga "Fosinopril" u ogolaan in laga saaro hypertrophy myocardial iyo ilmogaleenka ee ventricle bidix, iyadoo ay wada joogaan ee xaaladaha sida ay gacan ay hareen. Daawada hakiyo formation of aldosterone oo waa la fuliyay in qanjidhada adrenal, kordhiyaa dhaqdhaqaaqa nidaamka kallikrein-kinin ah, xasilinta content bradykinin in unugyo iyo dhiig. therapy Sababo ku salaysan isticmaalka "fosinopril" walxaha korodhka liberatiou kuwaas oo wanaajin ququlka dhiiga ee u kelyaha ah, waxay leeyihiin natriuretic, tallaabo vasorelaxant. medicament The yaraynaysaa wax soo saarka Horomonka arginine iyo endothelin-1, taas oo tallaabo vasoconstrictor.

By yareynta cadaadiska (diastolic, systolic) ma horumariyaan, iyo dareen-celin tachycardia orthostatic postural aysan waxba ka beddelin BCC. Ma jiraan wax isbeddel ah ee waxqabadka reflex ee myocardium, kelyaha iyo socodka dhiigga maskaxda. Waxaa uu ahaa xadgudub ma ququlka dhiiga ee u maqaarka, xubnaha gudaha, unugyada muruqa lafaha ah.

Sida buuga edbinta, "Fosinopril" isticmaalaa in dose hal, waxay leedahay tallaabo ah hypotensive kaas oo inta badan waxaa loogu dhawaaqaa ku dhowaayeen shan saacadood ka dib. Saamaynta keentay waxaa la hadhay maalin kasta, taas oo kuu ogolaanaya in aad sii a-beegyada uu dhiig karka caadiga ah. Si aad u soo bandhigaan saamaynta ugu badan ee suurtogalka ah ayaa loo baahan yahay in ay ku maray dhowr toddobaad.

Inta lagu guda jiro daawaynta "fosinopril" hypertension hagaajin kartaa jawaabta jirka ee hoos u deg deg ah ee dhiig-karka systemic. Marka therapy weheliso thiazides oo macnihiisu yahay "Fosinopril" muuqataa waxqabadka antihypertensive inta badan sameysa. Haddii loo baahdo, burin ah "fosinopril" ma horumariyaan syndrome ah, ma aha xitaa in kiiska marka la joojiyo waxaa si weyn sameeyey. Diyaarinta hagaajinaysaa bukaanka marka adag dal qaab wadnaha chronic, iyo sidoo kale jawaabta jirka ee cadaadiska jirka.

Marka laga dibad guryaha mutagenic iyo genotoxic in muddada daryeelka "Fosinopril" guide daawo bandhigayaa maqan. Si kastaba ha ahaatee, isticmaalka qaadasho cytotoxic keenaysaa in xanuunada qaar ka mid ah ee la xidhiidha aberrations koromosoomyada. Studies ayaa la sameeyay in jiirarka iyo jiirka muujisay in dose maalin walba aan ka badnayn 400 mg / kg ma keenaan wax astaamo ah carcinogenicity. Sababo la qaadasho sare ee jiirka lab Walxaha lipomas inta badan u muuqday. qaadasho Daily daroogada ilaa 60 mg / kg in jiirka ma keeni xanuunada la xiriira hirgelinta function taranka. Marka ay maamusho medicament jiir uurka (maalin qiyaasta ilaa 400 mg / kg maalintii) iyo bakaylaha (maalin dose 40 mg / kg) ka dhacay sarkhaan, daroogada si xun u saameyn koorsada ee uurka.

Nuugid ka dhigan tahay "Fosinopril" Codsiga User lagu gartaa sida gaabis ah, ay sabab u tahay hoos u cunto dheeraad ah. By sababta oo ah wax yar ka-pass ugu horeysay bioavailability Dheef (36%). "Fosinopril" hydrolyzed, habka ay taasi dhacdo in dhiigga, beerka iyo caloosha iyo mindhicirka qolof ay sabab u tahay hirgelinta fozinoprilat sameeyay, taas oo metabolite firfircoon. Heerka ugu badan ee daawada ee jirka waxaa laga helaa celcelis ahaan saddex saacadood ka dib markii ay codsiga. Half-nolosha dhacdaa 12-15 saacadood. Isgaarsiinta la plasma durba waa complete - ilaa 98%, mugga of qaybinta waa yar yahay.

Daawada uusan ku xadgudbayn caqabadaha xadka mandheerta iyo dhiig-maskaxda, muddada daryeelka joogo in caanaha naaska. In cirrhosis (khamriga, biliary) ansixin hoos, hydrolysis si tartiib ah soo baxa. In la'aan kelyaha dhacdaa diatsidnyh carqalad Digo metabolites firfircoon, daroogada isku uruursadaan laga yaabaa in ee jirka ku jira. Isticmaalka dialysis in ka shaqeeyo "Fosinopril" qaab diiwaanka laga saaro daroogada sida action ah oo aan soo saaro natiijada la rabay.

Tilmaamayaasha "Fosinopril" diyaarinta

"Fosinopril" loogu wadnaha iyo dhiig-karka. Xaaladda hore, daroogada waa aasaas u ah therapy dheeraad ah, in dhismaha labaad waxaa loo isticmaalaa daaweynta iyo monotherapy.

Daaweynta la "Fosinopril"

Sida caadiga ah, kiniin waxaa la cabo hal ama laba jeer maalintii in waqti isku mid ah. In daaweynta ee hypertension talinayaa ugu horeysay 10 mg ah daroogada, iyo ka dib - 20-40 mg. In daaweynta isku dhafan, marka laga reebo "fosinopril" waxaa loo isticmaalaa lagu durayo, qaadashada 10 mg ah ee daawada. Xaaladdan oo kale, la socodka joogtada ah ee dhiig-karka, qiyaasta ugu badan ee suurto galka ah ee daroogada waa 80 mg maalintii. Haddii daroogada, qiyaas kale ma laab ahaa booday. qaadasho Daaweynta soo saaray iyadoo la isticmaalayo qalab lagu taliyey by dhakhtar ma qaadan kartaa qadar weyn ama yar yar ee daawada oo ay kordhiso soo noqnoqoshada isticmaalka, mana samayn kartaa joojiyo "fosinopril" oo aan la tashan dhakhtar.

Ka hor inta daawada "Fosinopril" Buuggan talinayaa in aad tijaabiso heerka uu kordhay cadaadiska dhiigga. In magacaabista daaweynta tixgelinayo xaaladaha caafimaad oo kala duwan, dhakhtarku waa in si joogto ah loola socdo xaaladda bukaanka.

Si loo yareeyo khatarta ka mid ah horumarinta ee hypertension sare, qiyaas yar waxaa lagu talinayaa in wakhtiga hurdada. daaweynta Antihypertensive baajiso toddoba maalmood ka hor bilowga ah therapy, "fosinopril". Haddii aad horey u sameeyaa therapy durayo waa si loo yareeyo khatarta ka mid ah hypotension astaamaha, saxo dheelitirka biyaha iyo elektrolytka, durayo oo si weyn u yareeyo qiyaasta, xaaladaha qaarkood, joojin qaadashada daawada gebi (for 4-7 maalmood ka hor marka ugu horeeysa ee "fosinopril").

Ka dib markii therapy Wadnaxanuun myocardial macnaheedu yahay "Fosinopril" edbinta ku saabsan codsiga kuu ogolaanayaa inaad si ay u bilaabaan saddex maalmood ka dib. Inta lagu jiro daaweynta u baahan tahay cabirka caadiga ah ee cadaadiska dhiigga iyo qaababka baaritaanka dhiigga durugsan (hubiyaa ka hor therapy, kontaroolada 3-6 bilood therapy in xaqiijinta mustaqbalka gudahood lagu sameeyaa sanad kasta, la socodka inta badan soo noqnoqda waxaa laga yaabaa in loo baahdo markii itimaalka sare ee dhacdo of neutropenia). Intaas waxaa sii dheer, waxaa lagama maarmaan ah in la xakameeyo miisaanka jidhka, hubi xaaladda kelyaha iyo heerarka kariyaatiniin, potassium in kooban of protein plasma, nitrogen HOL dhiigga. Inta lagu jiro daaweynta aad u baahan tahay in la raaco cunto.

Bukaan-socodka kuwaas oo malignant hypertension leeyahay qiyaas qof daawo si tartiib ah kor u kacay (habeen walba), ka fiirsaneysa inay isbedel ah ee dhiig-karka, halka ay saamayn la gaarsiiyaa doonaa.

Sababo in la helo "Fosinopril" daroogada

Marka uu u xilsaarayo kiniin "Fosinopril" muujinaya in loo isticmaalo waxaa loo tixgeliyaa in isku mar la sababo. Daawada waxaa looma isticmaalo in ay dhacdo diidmo in qaybaha iyo daroogooyinka kale ee la mid ah. Daawooyinka aan qoray in bukaanada ay da'doodu ka yar tahay 18 sano jir iyo haweenka uurka leh, dumarka naas. Contraindication waxaa si xoogan dal renal failure. Sababo ka mid ah anjioedema (idiopathic, dhaxlo) sida hadiyad waqtiga ballanta ee daroogada, iyo sidoo kale kuwa ay leeyihiin taariikh hyperkalemia muujiyay, hypotension.

uurka

Kiniiniga "Fosinopril" diiwaanka mamnuucaya isticmaalka inta ay uurka leedahay, maxaa yeelay daawooyinka noocan ah waxay keeni kartaa in xanuunada koritaanka iyo dhimasho uurjiifka.

Haddii aad uur leedahay waa muddada hirgelinta daaweynta ay u baahan tahay la baabiiyo deg deg ah ee daroogada. Xaaladaha noocaas ah, waxbarasho ultrasound ah in la ogaado in ilmaha caloosha ku dhib.

dhasha A oo hooyadeed ay ula dhaqmay intii ay uurka leedahay "fosinopril", waxaa laga heli karaa hyperkalemia, hypotension, oliguria. Haddii horumariyo oliguria, waxaa muhiim ah in taageero la siiyo perfusion kelyaha iyo cadaadiska dhiigga baaro si joogto ah. Haddii shuqullada kelyaha iyo si ay u caadiga ah cadaadiska dhiigga lagu sameeyo mogzhet shubo ama dialysis.

Xudduudka isticmaalka "Fosinopril" diyaarinta

At si dhib leh ku Socota shalalka waa in ay tixgeliyaan saamiga faa'iidooyinka iyo halista ka iman karta ee daawaynta ka dhigan tahay "Fosinopril". Tilmaamaha loogu isticmaalo, jawaabaha ayaa tilmaamaya baahida loo qabo in la tixgeliyo khataraha iyo faa'iidooyinka ku jira arrimaha soo socda:

• cudurka halbowlaha wadnaha,
• joogitaanka of kelyaha bukaanka transplanted ah;
• turqo,
• diabetes;
• taariikhda anjioedema;
• Foomamka chronic of cudurada sanbabada obstructive;
• hyperkalemia la index ka badan 5.5 mmol / l weyn;
• sadha;
• cirrhosis,
• isbedel obstructive, Ulasocto dheecaanka dhiigga oo yaraada, qalbigay ka (stenosis aortic, mitral);
• wadnaha daran;
• cunto, bixinta qaadashada kooban oo content cusbo ama caddadka ugu yar ee sodium in cuntada wada baabbe'een;
• hyponatremia;
• leukopenia, Torombositobiiniya;
• nidaamyada qaar ka mid ah (dialysis, suuxdinta) hawlgalka;
• atherosclerosis, taas oo saameyn ku addimada hoose;
• fuuqbaxa;
• kariyaatiniin renal failure kor 300 pmol / L;
• da 'weyn;
• hepatitis;
• dhibaatooyin la xiriira maskaxda iyo socodka dhiigga wadnaha;
• stenosis;
• xaaladaha, taas oo hoos u BCC.

Dhibaatooyinka ay keento ka "Fosinopril" daroogada

Available si medicament ee dib u eegista "Fosinopril" iyo guide tarjumaya suurtagalnimada of horumarinta waxyeelo qaarkood. ku dhici kara xanuunada nidaamka hematopoiesis iyo nidaamka wadnaha iyo. isbedel suurtogalka ah ee habka dareemayaasha jirka, habka dheef shiidka, horumarinta kaskooda ku hawl. Bukaanjiifka qaar ayaa lahaa isbedel ku koobin shaybaarka iyo dhacdooyinka xun, muujinta maqaarka saameysey, nidaamka muruqyada. laga yaabaa inuu dhaco rabshooyin ee qaabka neefsashada iyo Fistula. Waxaa ka mid ah cadaanyo kale oo jirka loo kasin - hyperhidrosis, miisaanka oo yaraada, matag, qandho, barar angioneurotic, horumarka jirka ee geedi socodka faafa ama geedi socodka bararka ee qanjidhada, Lymphadenopathy, sii xumaanaysa ee turqo. wax dhibaato ah inta lagu guda jiro daawaynta waa in la soo wariyay in dhakhtarkaaga. khatarta sare ee dhacdooyinkan gurracan ee la xidhiidha si xun u isticmaalka daroogada.

Iska badinta "Fosinopril" daroogada

In daaweynta daroogada, jawaabaha "Fosinopril" tilmaamaya itimaalka jiritaanka badinta natiijo ahaan aad iyo aad u dose lagu taliyay. Iska badinta waxaa ku weheliyay daliilka ba'an ee hypotension, kelyaha, maskax hurudda, shoog, bradycardia, qas ah dheelitirka biyaha iyo elektrolytka.

Keena qiyaas hoos u dhac ama baabi'inta caloosha medicament maydhay ah oo la siiyo bukaanka ay cabbaan sorbent ah. Waxaa muhiim ah in dadka ay qaataan meel siman, waxaa muhiim ah in lagu fuliyo tallaabooyinka loogu talagalay kordhaya BCC ah. Waxa kale oo u baahan daaweynta calaamadaha. Kaadi ay dhacdo in this ma siin saamaynta ay ku doonay.

dhexgalka Drug "Fosinopril" diyaarinta

itimaalka ee dhacdo of hyperkalemia ugu sareeya marka la isticmaalayo daroogada, oo ka kooban bedel cusbo potassium, Cyclosporine, dheeri ah la potassium, diuretics potassium-uubatooyin xunxun.

Saamaynta daroogada noqdo muujiyeen si cad in isticmaalka siyaabo kale, waxay leedahay saamayn hypotensive, iyo khamriga. saamayn A ka nugul yihiin filayaa joogo oo sabab u ah isticmaalka walxaha in kiciyo nidaamka renin-angiotensin-aldosterone ah, estrogen, NSAIDs iyo sympathomimetics. Xaaladaha noocaas ah waxaa lagama maarmaan ah in ay diidaan in ay aqbalaan lacag ama bedelo "Fosinopril". Analogs lagu doorto uu dhakhtarka xaadirka ah. On suurtagalnimada ee isku daroogada daawooyin kale oo laga heli karaa takhasus u leh.

Analogs, micne ah "Fosinopril" daroogada

"Fosinopril" ayaa micne ah iyo analogues. Waayo, micne ah waxaa iska leh "Fosinopril-Teva", "Monopril." From kooxdan oo ah daroogo soo saaray "Fosinopril-OBL», «Fozikard". Of micne ah waxaad dooran kartaa "Fozinal", "Fozinotek".

Marka daaweynta ma oggolaan macnaheedu yahay "Fosinopril" tilmaamaha loo isticmaalo, micne ah ama analogs magacaabay takhasus si loogu daweeyo. Analogs "Berliprilom ',' Renitec '" ramipril "," Moeksom "," lisinopril ". analogs yaqaan sidoo kale leh "Prestarium", "Enap" iyo "enalapril". Of analogues la magacaabin "Tritatse", "Akkupro", "captopril". daaweynta suurtogalka ah la isticmaalayo "Charter" ama "Prenessa".

Haddii uu mamnuucayaa isticmaalka daawada tilmaamaha "Fosinopril" loo isticmaalo, analogs ama micne dooran go'aansado ku takhasusay.

Reviews of diyaarinta "Fosinopril"

Waxaa muhiim ah in aad doorato daaweynta saxda ah anti-hypertensive bukaanka, iyada oo la tixgelinayo dhegyadii ee jidhkiisa. Haddii "Fosinopril" Qofka daroogada ku haboon, cadaadiska waxaa ku ool ah hoos u, iyo waxyeelo ku ma dhacdo. Sida dib u eegista ah, waxaa jira xasilinta ka mid ah dhiig-karka, hagaajinaysaa caafimaadka guud. Haddii dhibaato jidhka iyo lagu arkay, iyagu waa khafiif ah, inta badan waxay dhadhamin qas, bafinayo, qufac.

Cadaadis dhiig oo sarreeya waxay keeni kartaa dhibaatooyin halis ah ee la xidhiidha dhaawaca xubnaha muhiimka ah, si aad u baahan tahay waqti si ay u sameeyaan daaweynta lagama maarmaanka ah oo akhri description ee daawada analogues "Fosinopril", si ay u bartaan macluumaadka kale ee waxtar leh.