Erythropoietin Recombinant. erythropoietin aadanaha Recombinant

Erythropoietin (Epo) - glycoprotein hormone koontaroosha heerka of erythropoiesis in aadanuhu. xarunta joogo uu ku dhexsameeysmo ugu horayn in kelyaha, qadar yar (10 boqolkiiba) waxaa la soo saaray ee beerka. erythropoietin hormone The shidaa heerka iyo kaladuwan ee progenitors erythroid. Heerarka hormone qoomiyadda ee plasma dhiig ah oo ay shakhsiyaad caafimaad ee kala duwan gudahood tiro balaadhan oo dhigmayn saami la fiirsashada haemoglobin iyo heerka uu Oxygen ee unugyada. Work on the go'doomin iyo wax soo saarka ee hormone si ay u daawada waa mid aad u faa'iido leh.

Qaab dhismeedka iyo qiimaha hormone

Britain ayaa waxay ka kooban acids amino hormone. Ugu yaraan of erythropoietin qoomiyadda ayaa hoos u dhac af ee heerka hemoglobin iyo unugyada dhiigga cas, waxaa la soo koraya ee loo yaqaan dhiig eritropoetindefitsitnaya ah. ku hadhay wax aan macquul aheyn sababo la xiriira la'aanta dawooyinka ku habboon Illaa dhowaan, sida la saxo daroogada ah oo dhiig la'aan ah. Maanta, khasaare kor hormone ee jidhka bini'aadamka, dhakhaatiirta qori erythropoietin recombinant. diyaarinta ka soo unugyada xayawaanka helay taas oo ah code hiddo soo bandhigay for aadanaha Epo. erythropoietin aadanaha Recombinant in acid amino iyo Halabuurka carbohydrate waa inay isku hormone dabiiciga ah, waxay kordhisaa tirada unugyada dhiigga cas, reticulocytes, shidaa biosynthesis ee unugga dhiigga cas ee unugyada. Waxqabadka noolaha ah waxyaabaha ka dhalanaya jiro kala duwan oo ka hormoonka qoomiyadda. erythropoietin Recombinant ma muujiyaan saamaynta cytotoxic iyo wax saameyn ah kuma leucopoiesis ah. Seynisyahanno soo jeedinaya in Epo macaamila receptors eritropoetinchuvstvitelnymi gaar ah, kuwaas oo ku yaala dusha sare gacanta.

nidaamka A daahiriyo erythropoietin aadanaha recombinant

Recombinant Epo aadanaha - waa mid ka mid ah borotiinka ugu badan soo saaray shirkado badan oo noolaha iyo dawooyinka adduunka oo therapy daroogada. xarunta joogo uu ku dhexsameeysmo unugyada ugxan hamster Chinese (Cho) by farsamooyinka DNA recombinant. Mid ka mid ah polypeptide silsilad recombinant Epo ka kooban yahay 165 acids amino, oo miisaankiisuna wuxuu xisaabiyaa kelli 24,000 Haa, oo dharka miisaankiisuna wuxuu arkay kelli ah borotiinka glycosylated - 30 400 Da. erythropoietin Branch ka nijaasta waxaa lagu fuliyaa by ra'iyi-dhaafsiga iyo chromatography buuna. Human recombinant Epo ayaa ka khayroon daahirnimo ka mid ah 98%.

erythropoietin Recombinant iyo analogs dhanba

Si aad u kicin dhakhaatiirta habka erythropoiesis isticmaala daroogada kala duwan:

• "Aranesp";
• "Aeprin";
• "Epobiokrin";
• "Bioein";
• "Vepoks";
• "Binokrit";
• "Epokrin";
• "Gemax";
• "Epogen";
• "Eprex";
• "Epovitan";
• "Epomaks";
• "Giperkrit";
• "Eralfon";
• "Eritrea";
• "Recormon";
• "Epostim";
• "Epozino";
• "Epoetin Beta".

Ka hor inta aadan bedeli a analogues erythropoietin recombinant, waa in la tasho dhakhtar.

Tilmaamayaasha

Xirfadlayaasha Caafimaadka inta badan u leeyihiin in ay la anemia eritropoetindefitsitnymi (EDA) macaamilo. Kooxdan waxaa ka mid ah heley soo socda:

• anemia of neoplasms malignant,
• anemia hore ee socod baradka dhicisnimada (ka hor 34 asbuuc uurka) la miisaanka jidhka ka mid ah 750 si 1500 g;
• anemia nephrogenic;
• Dhiig cudurada raaga (hepatitis C, rheumatoid arthritis, cudurka HIV, cudurada marinka alimentary).

feature A ee kala duwan ee dhiig yaraanta kor-waa xaqiiqda ah in ay yihiin aan la daaweyn diyaarinta bir ah. Ilaa dhawaan, therapy kaliya wax ku ool yahay shubo ah. Sababo la xaqiiqada ah in noocan ah therapy uu leeyahay tiro badan oo waxyeelo iyo halis sare oo gudbinta wareer ah dhiigga ka dhasha cudurada khatarta ah faafa (HIV, fayrusyada hepatitis, iwm), habka this ee daawada casriga ah waxaa ku dhowaad marnaba loo isticmaalo. erythropoietin aadanaha Recombinant ka caawisaa si loo hagaajiyo tayada nolosha ee bukaanka qaba cudurka ah "dhiig eritropoetindefitsitnaya." Biosynthesis iyo sal-dhigida ee recombinant aadanaha Epo furay marxalad cusub ee daaweynta ee eritropoetinzavisimyh anemia.

sababo

Dhakhaatiirta ha ku talinaynaa isticmaalka erythropoietin recombinant (manual ka digay ku saabsan) iyadoo ay wada joogaan oo ka mid ah heley soo socda:

• thromboembolism;
• diidmo in daroogada;
• adagtahay in daaweynta xinjirowga lidka ku ool ah;
• wareejiyo stroke cerebral ama Wadnaxanuun myocardial;
• angina deganayn,
• hypertension caasiyoobay,
• xilliga dhalmada iyo naas-nuujinta;
• hypertension madax adkaadeen.

mudada kacmaha

The qiyaasta iyo muddada nidaamka daaweynta adkeeyey sal adag shaqsiga, iyada oo ku xiran darnaanta anemia, xaaladda guud ee bukaan-socodka iyo nooca cudurada ka. Daawada waxaa loogu tala galay isticmaalka parenteral. qaadasho Bilowga kala duwanaan karaan in kala duwan oo ka soo 50 ilaa 150 IU / kg. Qiyaasta waa in la hagaajiyo ku xiran da'da qofka bukaanka ah. erythropoietin Recombinant waxaa badanaa maamula 3 jeer toddobaadkii. Haddii xad dhaafka ah ayaa la sii kordhaya waxyeelo. Natiijadan ayaa waxa uu noqonayaa mid ka badan ama ka yar la arki karo 2-3 toddobaad ee codsiga ka dib.

dhibaato

Waxaad magacaabay erythropoietin aadanaha recombinant? Tilmaamaha Isticmaalka meesha kama saarayso horumarinta waxyeellooyin. Waxay kala yihiin:

• myalgia;
• wareer;
• hyperthermia;
• dawakhsanaan;
• matag,
• madax-xanuun,
• shuban;
• arthralgia;
• hypertension,
• feedho xanuun,
• thrombocytosis;
• tachycardia;
• dhibaatooyinka hypertensive;
• gariir,
• tobnad;
• korinta heerka AST, ALT dhiigga;
• erythrocyte aplasia cell jeermiga;
• cambaarta,
• anjioedema,
• finan maqaarka ah iyo cuncun;
• asthenia;
• finan, casaan iyo goobta maamulka gubanaya;
• hyperkalemia;
• hoos u fiirsashada protein ee birta plasma;
• hyperphosphatemia.

kiciya Erythropoiesis ciyaaraha

Recently, si joogto ah loo isticmaalo daroogada "Epovitan" (erythropoietin aadanaha recombinant). qalab xaadirka ah waxaa badanaa loo isticmaalaa in sports (ciyaaraha, bodybuilding, dabaasha, biathlon). Ayaa sheegay in diyaarinta shidaa biosynthesis ee unugyada dhiigga cas, taas oo keenta in la kordhiyo content ee oxygen halkii mugga unit oo dhiigga iyo, sidaas awgeed, in la kordhiyo awoodda oxygen dhiigga iyo O ₂ bixinta si ay xubnaha iyo unugyada. Tani qaab hawleed kordhiyaa dulqaadashada laylinta ee ciyaaraha fudud ah. Saameyn la mid ah ayaa lagu arkay marka tababarka ciyaaryahan ah in Midlands ah, halkaas oo ay la'aanta ah ee O ₂ hawada keena horumarinta hypoxia, taas oo iyana shidaa biosynthesis ee erythropoietin qoomiyadda. diyaarinta Epo waxaa loo isticmaalaa in lagu daro insulin, hormone koritaanka (la bixinin, somatotropin) iyo stanazolol.

Xad-dhaaf ah, isticmaalka caasiyoobay ah "erythropoietin" daroogada ee sports keeni kartaa xinjiro dhiig oo caadi ahaan waddooyinka dhimashada. Ogaado recombinant Epo waa kuwo ku adag, sababta oo ah qaabka xeryahooda dardaro waa isku mid ay analog jir, sidaas biosoedinenie this weli sharci-darro ah loo isticmaalo sida ay qorayeen in sports-waxqabadka sare.