Daaweynta "sofosbuvir": dib u eegista. "Sofosbuvir" + "Daklatasvir": dib u eegista ku takhasusay. "Sofosbuvir": edbinta ku saabsan dib u eegista dhakhaatiirta

Beerku waa nooc ka mid ah filter daahirinta dadka jidhka bini'aadamka. Xaaladda jidhka saameeyaa hawlaha nidaamyada badan iyo tayada nolosha aadanaha guud. Mid ka mid ah beerka ugu daran waxaa loo arkaa inay hepatitis C. Waqtigan xaadirka ah in ay la cudurka horumartay badan oo daawooyinka ka qabtaan. Mid ka mid ah qalabka ugu waxtarka badan waxaa loo arkaa (kaas oo la xaqiijiyay by the dib u eegista caafimaadka) "sofosbuvir".

Tilmaamayaasha loo isticmaalo

Guud ahaan sofosbuvir u bixiyey qayb firfircoon Alwaaxdii, iyo brand laftiisa uu leeyahay magaca ganacsiga "Sovaldi" ah. Sidaas darteed, waxaa suurtagal ah in la sheego in dawadan bedel jaban - generic "sofosbuvir" kaas oo dib u eegis ku tilmaami daroogada sida mid ka mid ah daroogada ee ugu waxtarka badan ee daaweynta cagaarshowga C. Tani waa meesha ugu muhiimsan ee codsiga.

wax Base - sofosbuvir - waa inhibitor ah NS5B polymerase ah viral, ie, uu hakiyo geedi socodka taranka viral - .. Wakiilka sababaya hepatitis C. Si kastaba ha ahaatee, khubarada caafimaadka badankiisu ma ku talinaynaa monotherapy "sofosbuvir" (in kasta oo ay tahay in mabda 'suurto gal). Laakiin sida qayb weyn ee firfircoon ee therapy isku dhafan ee daroogada fayruska "sofosbuvir" jawaabaha waxa uu leeyahay oo kaliya jihada wanaagsan, waxaa sifeeyay sida hab heer sare ah wax ku ool ah. Sida laga soo xigtay waxbarashada clinical sameeyay, daroogada waa tusmo daroogooyinka kale ay muujiyeen natiijo fiican ee lagu daaweeyo hepatitis C (noocyo 1, 2, 3).

Daaweynta "sofosbuvir" shaqaalaha caafimaadka ayaa jawaab-celin wanaagsan ma ahan oo keliya iyaga u bukaan marnaba loola dhaqmo, laakiin sidoo kale kuwa ay heleen therapy hor daawooyin kale oo fayruska, iyo dhamaadka daaweyn muddo ka dib si aad u hesho labakaclaynta.

Ka sokow aagga kor ku tilmaamay saamaynta, "sofosbuvir 'dib u eegista iyo talooyinka tilmaamo dhakhaatiirta ogolaan isticmaalka daaweynta bukaannada ka cabanaya cirrhosis of beerka.

Ku saabsan waxtarka daawada HIV iyo cagaarshow co-caabuq (xaalad si caddaalad ah wax caadi ah), macluumaadkan hadda ma laga heli karaa, in kasta oo daroogada waxa lagu tilmaamayaa si loogu isticmaalo xaaladaha sida.

sababo

Xaaladaha intooda badan, daroogada laftiisa iyo daawooyinka ay generic si fiican loo dulqaatay by bukaanka.

Si kastaba ha ahaatee medicament lagu daaweyn jiray hepatitis C "Sovaldi" (ama "sofosbuvir") jawaabaha kuwaas oo jihada wanaagsan, sida wax medicament aadka u hufan oo casri ah, uu leeyahay sababo codsiyada gaar ah.

Marka hore, taasi diidmo shakhsi si medicament ugu weyn iyo qaybaha kaabayaal ah. Waa in aad ka taxadartaa marka la isticmaalayo dumarka ku jira da'da dhalmada. Gaar ahaan, haddii "Sovaldi" ( "sofosbuvir") waxaa loo qoondeeyey in lala "Ribavirin" iyo "interferon-Alfa" (noocyo dhabta ah 3, 4, 5, 6, hepatitis) waa in laga fogaado in siyaabo kala duwan uurka. Waxaa sidoo kale aad u jecel yahay in lagu daweeyo wakiilada, kuwaas oo xilliga uurka iyo nuujinta.

Currently, saamaynta ka mid ah "sofosbuvir" macluumaad aadanaha taranka waa la heli karaa. Sidoo kale waxaa jira war ah kama on ammaanka iyo waxtarka of daroogada ee bukaanka ka yar da'da 18 sano.

Qiyaasta iyo muddada dabcan therapy

First waa in ay farayaan in therapy ee fayruska la aqbali karo in ay fuliyaan oo kaliya kuwa xirfadlayaasha caafimaad qaba waayo-aragnimo ku filan in daaweynta bukaannada ka cabanaya hepatitis C. A caadiga ah mudada - 1 kiniin ah (400 mg oo ah walaxda firfircoon) inta lagu jiro maalinta, inta lagu jiro xilliga kasta oo uu qofku cuno. Sida pill qadhaadhka ah (sida ka qaadato dib u eegista daawo) "sofosbuvir" in la wada liqo oo aan xanjo ama jebinta ah.

Haddii kiniin la qaatay, oo intaas ka dib in 2 saacadood ee soo socota laga bilaabo matag, waxaa lagu talinayaa in ay qaataan hal kaniini oo kale. In the case of matag muddo ah markii uu joogsadey, in ka badan 2 saacadood, qaadan qiyaas dheeraad ah ma loo baahan yahay.

Haddii qiyaasta xiga sabab qaar ka soo baxay in la boodboodeen (muddada dib u dhac aan ka badnayn 18 saacadood), waxaa lagu talinayaa in ay qaataan qiyaasta seegay ka dibna markii ugu caadiga ah in ay sii wadaan daaweyn. Haddii dib u dhac ka badan 18 saacadood - qaadan dose soo socda waqtiga caadiga ah.

daaweynta isku dhafan

Sida qaybaha prolechivanii therapy Curiyaha taageerada ee hepatitis C, ay la socdaan "sofosbuvir" dhaqma shaqo "ribavirin", "interferon Alfa", "Daklatasvira", "Ledipasvira", "Asunaprevira".

Guud ahaan, tusmo ah "sofosbuvir" + "Daklatasvir" dib u eegis ku shaqaalaha daryeelka caafimaadka iyo bukaanka lagu gartaa sida wax ku ool ka dhanka ah noocyo kala hepatitis C 1,2,3.

Si aad u taariikhda, "Daklatasvir" waxaa laga dalban karaa online WWW.ARV24.COM u dhiibay in aad gacmahaaga - in shirkad la sumcad dheer-taagan. Waase in halkaas on gacanta yihiin dhammaan xogta muhiimka ah ee ku saabsan joogitaanka cudurka.

Noocyo 4, 5, 6 lagu daweynayaa medicaments adag "sofosbuvir", "ribavirin" iyo "Alfa interferon". muddada daweynta Standard waa ugu yaraan 12 toddobaad. Xaaladaha meesha bukaanka qaba noocyo 1, 4, 5, 6 leeyihiin sababo u helo "Alfa interferon" ayaa lagu wadaa ama diidmo in walaxda, "sofosbuvir" with "Ribavirin" waxaa loo xilsaaray in ay helaan 24 todobaad.

Tusmo "Ribavirin" with "sofosbuvir" daroogada genotype 2 eegista ku takhasusay ayaa sidoo kale sharaxaad ka bixi sida ay u fiican loogama wax ku ool ah oo isku jira oo la qoondeeyey in ay qaataan muddo aan ka yarayn 12 toddobaad. Labadan medicament, laakiin in muddo ah ugu yaraan 24 toddobaad, markii ay codsatay 3 genotype cagaarshowga C.

Warbixin ku saabsan waxtarka of therapy isku dhafan oo "Ribavirin" iyo "interferon" oo lagu daweeyo genotype 1 aan la heli karin.

Haddii ay sidaa tahay, haddii xanuunka haya bukaanka ka hepatocarcinoma iyo / ama sugaya qaliin beerka, dhaqanka lagu magacaabayo "sofosbuvir" isku dhafan oo "Ribavirin" 48 toddobaad ama ilaa taariikhda qaliin xubin ah. Tani waa muhiim si looga hortago cudurka beerka ka dib markii xubin badalida.

waxbarashada Clinical soo jeedinaya in isku soo dhaweynta "sofosbuvir" daawooyin kale siisaa jawaab deggan wanaagsan fayruska in 92% ka mid ah xaaladaha ka mid ah therapy Curiyaha taageerada ee daaweynta ee hepatitis C.

waxyeelooyinka suurogalka ah

In koorsada of tijaabo daroogada waa mid aad u fiican loo dulqaatay by bukaanka (sida ay ahaayeen ratings) oo. "Sofosbuvir" sababa dhacdooyinkan gurracan ee kiisaska intooda badan marka loo isticmaalo in lagu daro "Ribavirin" iyo "interferon".

Marka lagu daro "sofosbuvir" with "Ribavirin" inta badan ku filan (in ka badan 10% ee kiisaska) ee fiirsashada hemoglobin, iyo kor u bilirubin laga yaabaa muujinta daal hoos ka kooban dhiig, caro iyo hurdo la'aan, lallabo.

In ka yar caadi ah (in ka yar 10% ee kiisaska), isku darka this daroogada dhirfinaya murugada, dhiig yari, nasopharyngitis, fiirsashada oo yaraada, dyspepsia, calool-iyo cudurada caloosha, dareen diidmo oo xasaasiyadeed ee maqaarka (cuncun, finan). Marmarka qaarkood bukaanka ku hadhay, iyo ratings kuwan "sofosbuvir" loo isticmaalo barbar "Ribavirin" sabab u ahayd timaha oo daata iyo dhabar xanuunka, casiraad, myalgia, iyo asthenia.

Haddii aad isticmaasho adag oo ah saddex daawooyinka (laba kor ku magacaaban daray "Alfa interferon"), marar aad u badan (in ka badan 10% ee kiisaska) waxaa jira liis aad u ballaaran of dhacdooyinkan gurracan. Halkan waxaan ka hadleynaa isbeddel ah ee dhiigga, waxaa la yareeyo tirada limfosaytis, neutrophils iyo platelets, dhiig-yaraan, heer bilirubin kacsantahay. On qayb ka mid ah marinka dheef shiidka laga yaabaa in shuban, lallabo, matag. Intaa waxaa dheer, "sofosbuvir" (Instruction, Kurtumm bukaanka iyo shaqaalaha caafimaadka ay taageeraan) waxay keeni kartaa madax xanuun, wareer, qufac, xiiq, cuncun iyo finan, myalgia iyo xanuun. Bukaanka inta badan ka hadlaan daal, caro, matag, korodhay heerkulka jidhka.

In ka yar caadi ah (1 ilaa 10%) bukaanka yidhaahdo oo ku saabsan cabsida iyo horumarinta murugada, si loo yareeyo miisaanka jidhka, ku saabsan xasuusta iyo ka-fiirsashada leexashooyinkaasi ee jaf. Waxaa jira macluumaad ku saabsan sii daraysa ee aragtida, timaha, horumarinta reflux iyo neefta oo ku qabata markii load kordhay. Marmarka qaarkood bukaanka yidhaahdo oo ku saabsan xanuunka ee dhabarka iyo xabadka, casiraad iyo daal.

Waxa aad u baahan tahay inaad ogaato?

Haddii bukaanka uu leeyahay hal ama ka badan taban arrimood - sare bilowga load viral, cystic marayaan meel sarre, maqaarka aad u madow - daaweynta "sofosbuvir" (dib u eegista khubaro iyo tilmaamaha sida loo isticmaalo taageero) kordhin kara ilaa 24 todobaad. Marka la qabanaayo therapy isku darka qiyaasta wax ku ool ah "ribavirin" la doorto sida uu miisaanka jidhka ee bukaan-socodka, ie. E. 75 kg miisaanka jidhka u baahan yihiin 1.2 g of medicament. lacagta oo dhan sida daroogada waxaa loo kala qaybiyaa laba qaybood oo lala qaataa cuntada.

Iska yaree "sofosbuvir" qiyaasta laguma talinayo.

Haddii codsiga wadajirka ah "Solfosbuvira" iyo "Alfa interferon" horumariyaan daliilka negative caan ku daroogada dambe, helay qiyaas ah "interferon" waxaa loo baahan yahay in la yareeyo ama xataa joojin qaadashada daawada this (xeerarka faahfaahsan oo ku saabsan yareynta dose ama bixitaanka of daroogada, waxaa jira tilmaamo gaar ah).

In si sax ah fal la mid ah marka ay jirto a "sofosbuvir" daro "Ribavirin", iyo horumarinta saamayn xun ku soo dhaweynta ee la soo dhaafay - hoos dose ama joojiyo gebi ahaanba soo dhaweynayaa, "Ribavirin". Ka dib markii loo hagaajiyo natiijooyinka baaritaanka dhiigga, waxa la aqbali karo in ay isku dayaan in ay dib u bilaabaan qaata "ribavirin", laga bilaabo 600 mg oo si tartiib ah u keeno 800 mg. Waxaa laguma talinayo in la kordhiyo qiyaasta in ay caga asalka ah.

Hadii aad joojisid mid ka mid ah therapy daawo la isku daray ee loo baahan yahay in gebi ahaan la joojiyo qaadashada "sofosbuvir" - comments ka khubarada iyo tilmaamaha loo isticmaalo tilmaamaha la mid yihiin arrintan la xiriira.

Dhexgalka waxyaabaha kale ee

Shaqaalaha caafimaadka ayaa aan lagu talinayaa in bukaanka ay barbar socdaan daroogada loo arkaa in ay isticmaalaan daroogo kale fayruska (marka laga reebo dhakhtarka daaweynta) in muddada marka daaweynta waxaa lagu fuliyaa hepatitis. "Sofosbuvir" dib u eegista khabiiro ka fiirsan waxa suurto gal ah in lagu biiriyo wax kale oo kaliya xaaladaha halkaas oo lacagta la filayo ka isku dhafan ee daroogada ka badan khataraha ka iman kara waxyeello ka soo gaartey.

Sidoo kale waxaa jira koox ka mid ah daroogada, isticmaalka wadajirka "sofosbuvir" ku ool ah hoos ugu dhigi kartaa in ay nuugista ( "sofosbuvir") ee xiidmaha. daawooyinkan - of anticonvulsants - waxaa ka mid ah "phenytoin", "Phenobarbital", "carbamazepine" iyo "Oxcarbazepine." daawooyinka group Antimycobacterial sidoo kale ka kooban yahay hab sida "Rifabutin", "Rifampicin", "Rifapentine". From supplements dhirta absorbability si weyn u hooseeya "sofosbuvir" Hypericum laga yaabaa. Sidoo kale laguma talinayo in la isu geeyo daawo la inhibitors protease HIV, "Tipranavir", "ritonavir".

tilmaamaha gaarka ah

Oo kaliya dhakhtarka abuurayaa doorashada saxda ah ee daawada hepatitis C, iyo daawooyinka loo qoro for "Ledipasvir", "Asunaprevir", "sofosbuvir", "Daklatasvir". Jawaab-celinta ka yimi bukaanjiifka oo dhan xabbo "Sovaldi" fiican.

Si kastaba ha ahaatee, waa in la dhasha maskaxda ku haysaa in, bukaanka qaba xumaanshaha kelyaha ee daran, mugga qiyaasta waa in si gaar ah loo doortay. Ma jirto baahi loo qabo in duulayaa qiyaasta kuwa ay dhibaatadu ka fudud in cudurka dhexdhexaad ah. Iyadoo la tixgelinayo beerka, ma jirto baahi loo qabo in la qabsato qiyaasta bukaanka qaba degree mid ka mid ah adkaanta cudurka.

In daaweynta cagaarshowga C iyadoo la isticmaalayo oo ku saleysan "sofosbuvir" therapy isku dhafan laguma talinayo in ay galaan kuwa hawlaha u baahan-fiirsashada sare iyo xawaaraha of falcelinta psychomotor.

kala duwan oo qiimaha

Qiimaha daroogada ku tilmaamay in Germany waa inta u dhaxaysa 18 ilaa 20 kun oo euros. Oo si aad u iibsato xataa qiimaha this u baahan doontaa warqad ka soo dhakhtarka dhigata. Noocan oo kale ah qiimaha sare ee wadarta ay sabab u tahay xaqiiqada ah in shirkadda sameeysa-leeyahay in lagu iibin doono kharashka oo dhan ay cilmi, horumarka iyo baaritaanka daroogada.

qiimaha wax badan ka jaban daawooyinka macaamilka, generic (analogues jaban brand la walax firfircoon gabi ahaanba isku mid). Waa in walaac sida "Daklatasvir", "Asunaprevir", "Ledipasvir" iyo "sofosbuvir". dib u eegista Consumer ku jira macluumaad ku saabsan qiimaha sare ee daawooyinkan, si kastaba ha ahaatee, waxaan aan la hadlayaan tobanaan kun oo euros.

Laga bilaabo March 2015, sida ay shatiyada shirkad-sameeysa, arrinta of "sofosbuvir" Ciidamada Natko bilaabay shirkadaha dawooyinka ee Indian (dabcan, ay oggolaansho ka Wasaaradda Caafimaadka of India).

Currently, Russia waa dhabta ah iyada oo loo marayo dukaamada online inaad iibsato xirmo ah (28 xabbo oo kiniin) daroogada "sofosbuvir" 39 900 rubles (1 kiniin ku kici doonto macaamiisha in xaddiga oo ku saabsan 1800 rubles). Waa raqiis ah ma, laakiin si sax ah Baakadaha ka mid ah ku tilmaamay "Sovaldi" u baahan doontaa maal ee cadadka 1.5 million rubles, taas oo ku dhawaad 35 jeer ka qaalisan qiimaha wax generic.

Iyada oo silsilado farmashiyaha ilaa aad ka iibsan kartaa daroogada this, t. Si aad. Habka caddeynta ee daroogada cusub ee Russia waa halkii dheer.

opinion ee macaamiisha iyo dhakhaatiirta

medicament The qaaday bukaannada qaba noocyo kala duwan ee cagaarshow, cystic heerar kala duwan leh indices of transaminase iyo aad uga sarreeyaan caadi ah, sida caadiga ah load sare viral.

Inta badan xad dhaafka ah ee bukaanka qaaday daawada, ka tago ra'yi-celin wanaagsan oo ku saabsan "sofosbuvir" waxaa loola jeedaa. Yaa ayaa lagu daweeyey (dib u eegista inta badan ku jira macluumaad sida) hore hepatitis interferons C jeedisay in daawooyinka aan xitaa is barbardhigi kartaa. Interferons keeni badan oo waxyeelo, iyo bukaanada oo dhan ma lahan awood ay kaga gee. Sida marka la isku daro "sofosbuvir" iyo "Daklatasvir" (inta badan bukaanada yidhaahdo oo ku saabsan tusmo sida a), kaliya tiro yar oo lagu daaweeyaa wakiilada hadlay oo ku saabsan horumarinta saamayn yar oo xun sida wareer, madax xanuun, aan xoog leh oo khasaaro muddada gaaban ee isuduwidda. Si kastaba ha ahaatee, calaamadahan ma in wax la barbardhigo dhibaatooyinka soo raaca oo ka mid ah "interferon" iyo cawaaqibka hepatitis tagaan. Marka ay dhamaato 2-3 toddobaad ee therapy in bukaan badan, dib to content caadiga ah ee transaminases beerka. Laga bilaabo toddobaadka saddexaad ee daaweynta antivirals adag "sofosbuvir" iyo "Daklatasvir" in bukaan badan oo ay joogaan in jirka ah ee fayraska hepatitis C xun.

Sidoo kale, dad badan oo buka soo sheegto si weyn ay hoos of fibrosis in dhowr bilood, isticmaalka daawada isku dhafka ah.

Kuwa macaamiisha kuwaas oo qaatay adag oo ah saddex daawooyinka - "sofosbuvir", "Daklatasvir", "Ribaverin" - ayaa sidoo kale aad ugu faraxsan natiijada daawaynta.

Ku dhowaad dhammaan macaamiisha "sofosbuvir" hadal ah oo ku saabsan xal dhab ah ee daaweynta ee hepatitis C marka la barbardhigo interferonotherapy. Si weyn loo hagaajiyo caafimaadka iyo tayada nolosha - inay cadeyn toos ah.