Codsiga iyo saamayn ah "Cefotaxime." "Cefotaxime": analoogga ah ee daroogada

Antibiotic "cefotaxime" - daroogada awood leh oo lagu daweeyo cudurada faafa iyo ka hortagga dhibaatooyin postoperative. Daawada dawadu jidhka u soo maraysaa duro, waxaa inta badan soo qoray loogu talagalay dadka waaweyn iyo carruurta. Waa antibiotic ah semisynthetic la sodium walaxda firfircoon sefotaksim.

saamaynta pharmacological

"Cefotaxime" - cephalosporins Wakiilka, tallaabo bactericidal la hubinayaa by xakamaynta of formation of derbiyada unug ka mid ah bakteeriyada.

Antimicrobial waxaa loogu talagalay isticmaalka parenteral, waa wax ku ool ah markii loo feydo Gram-negative bakteeriyada in ay yihiin adkaysi u antibiotics kale, ay awoodaan in ay u dhaqmaan on cocci garaam-positive, laakiin firfircoon ka yar bakteeriyada garaam-negative.

Pharmacokinetics

Daawada waxaa si degdeg ah nuugo, ku xiran qiyaasta waa in plasma shan daqiiqo ama nus saac ka dib markii la isku duro oo uu xusay in ay isugu soo urureen bactericidal dhiigga ku in ka badan 12 saacadood. Daawada waxaa soo galaya ee unugyada iyo dheecaanka, si fiican u qaybiyeen in. Marka loo isticmaalaa in daawada nuujinta heli kartaa caanaha naaska. The saamayn "Cefotaxime" ugu badnaan waxaa lagu gaarayaa marka uruureen wax ku ool ah synovial, xuubka hoose iyo dheecaannada pleural. Derivation waxaa la sameeyaa beddelin kaadida (60%) iyo qaab metabolites. Waayo, qeybtii nolosha iyada oo sababtu tahay V / m / iyo in loo baahan yahay 1 hr.

Tilmaamayaasha in loo isticmaalo ee medicament ah

Tilmaamayaasha ay u isticmaalaan daroogada waa dabeecadda faafa ee caabuq kaga xanaajiyeen by micro-organisms in ay yihiin xasaasiyadda kala duwan si ay "cefotaxime" (inta badan garaam-negative). Waxa la soo saaray waxaa loola jeedaa oo keliya irbado analogs "Cefotaxime" kiniinada heli karo, daroogada waxaa loo isticmaalaa in la aqoonsado dowlad-goboleedyada sida:

• caabuq saameeya saabka caloosha,
• lesions maqaarka, kala-goysyada, unugyada jilicsan iyo lafaha;
• cudurada ka mid ah neef-mareenka, sanka, cunaha, dhegaha,
• caabuqa ee waxyeela habdhiska kaadi mareenka,
• cudur ku faraxnay,
• bararka geedi socodka of faafa dabiiciga ah ee xubnaha miskaha, jabtada,
• gubasho, cudurka boogaha;
• meningitis, endocarditis, septicaemia,
• cudurada of difaacooda;
• ka hortagga cudurada faafa kadib markii qalliin (hawlgallada on xubnaha caloosha mareenka, iyo umulaha iyo cudurrada haweenka iyo nidaamyada urological).

sababo

analogues "Cefotaxime" irbado waxay leeyihiin sababo gaar ah oo ay tahay in la tixgeliyaa ka hor maamulka ka mid ah daroogada.

Daawada waa u lacala diidmo in benisiliinta, carbapenems iyo cephalosporins kale. Its si taxadar leh loogu beerka iyo kelyaha cudurada, ulcerös kolit, nuujinta. Haweenka uurka leh waxaa la qoray oo kaliya haddii ay jirto halis weyn ku leedahay uur jiifta ama hooyada ee jirka u malaynayeen in ay si weyn u ka faa'iideysan miisaan badan yihiin khataraha suurto gal. Marka loo isticmaalo ee la xiriirta carruurta da'doodu ka yar tahay 2.5 sano, lama oggola in la isticmaalo habka ay u duridda.

Isticmaalka daroogada, qiyaasta

Si aad u ogaato sida loo nooc "cefotaxime", waxaa lagama maarmaan ah inay akhriyaan macluumaadka la siiyey tilmaamaha loo isticmaalo daroogada. Daawooyinka loogu talagalay / m a iyo / hordhaca (via walax ama bolusdose).

Daawada waxaa qoray dadka bukaanka ka weyn 12 sano, marka miisaanka jidhka oo waa ka weyn yahay 50 kiilo garaam:

• cudurrada faafa ee mareenka kaadida iyo kuwa xaaladaha marka cudurka dhacdaa iyada oo aan dhib u shaqeeyo hab kasta heli karo 1 g of diyaarinta la dura 8-12 saacadood,
• Foomamka jabtada ba'an badnayn maamula waallayn by ee muruqyada dhexdooda wadada 1 g of daroogada,
• isticmaalayo daroogada si loogu daweeyo cudurada of nooca faafa, darnaanta taasoo dhexdhexaad ah, mid ka mid ah siyaabaha suurtogalka ah ee 1-2g waxaa maamula la periodicity ah waxay ka dhigan tahay 12 saacadood (ka hor inta geedka "Cefotaxime" ah, waxaa lagama maarmaan ah in ay si taxadar leh u bartaan xeerarka sidii oo xal ka waxaa loo diyaariyey isku duro) ;
• adag ka dhaca cudurada, tus, meningitis, u baahan hordhaca ah gelin xididka 2 g of daroogada dura 4-8 saacadood, iyadoo qiyaasta ugu badan ee maalin kasta laga yaabaa in aan ka badnayn 12 g, Muddada daaweynta waxaa lagu go'aamiyaa darnaanta xaaladda;
• ka hor inta lagu jiro hawlgallada suuxdinta si loo baabi'iyo suurtagalnimada cudurka waxaa maamula 1 g of daroogada, mararka qaarkood 6-12 saacadood waxaa lagu fuliyaa reintroduction ka dhigan tahay,
• qalniinka caloosha waxaa loo sameeyaa by bandhigid 1 g of "Cefotaxime" ka dib habraaca lagu celceliyo.

Daawada waxaa sidoo kale loo isticmaalaa intravenously ee la xiriirta caruurta dhiciska ah iyo dhallaanka:

• da'da ka yar tahay 1 toddobaad - isticmaalay 50 mg halkii 1 kg ee miisaanka jidhka la soo noqnoqoshada ah 12 saacadood,
• da'da 1 ilaa 4 toddobaad - 50 mg halkii 1 kg ee miisaanka jidhka la periodicity ah 8 saacadood.

Caruurta miisaankoodu ka yar yahay 50 kiilo garaam at da'da 2.5 sano, doorataa 4-6 Hordhac Mid ka mid ah hababka suurto galka ah ee 50-180 mg halkii kiilo ee miisaanka jidhka (in la gartaa sida "cefotaxime" novocaine sirdoonka, waa in aad si taxadar leh u akhri tilmaamaha) . Haddii uu jiro dabcan daran cudurka, isticmaalka 100-200 mg / kg. Ugu maalin ay tahay in 12 g of daroogada la aqbali karo.

Diyaarinta xal la isku duro

duridda xididdaha

The nadiif ah biyo la isku duro (4 ml) waxaa lagu qasi 1 g of daroogada. Xalka waxaa maamula in ka badan 3-5 daqiiqo, waxaa muhiim ah in ay bixiyaan bixinta a gaabis galay jidhka.

faleebo xididka (faleebo)

At 50-100 mL ee dareeraha (dextrose 5% ama sodium chloride 0.9% th) oo badhxan 1-2 g of daroogada iyo faleebo waxaa lagu fuliyaa for 50-60 daqiiqo.

muruqyada dhexdooda

In 4 ml of xal (1% -th xal novocaine, biyo la isku duro) qaataan 1 g of daroogada, ka dhigi irbado barida, irbadda waa in si qoto dheer galaan muruqa.

Compliance leh tilmaamaha dawooyinka la isticmaalayo

"Cefotaxime" analogues kiniinada taas waxaa laga heli karaa, codsatay in la raacayo tilmaamaha gaarka ah. Ka hor inta codsanaya daawo loo baahan yahay in laga saaro suurtagalnimada of xasaasiyad. Bukaanka noqon kartaa dareen xaasaasi ah in penicillin, daroogada waa in la isticmaalaa si taxadir leh xad-dhaaf ah. Haddii uu jiro dareen in walxaha ku jira sheyga, daawooyinka, isticmaalkeeda la joojiyo. In lagu daaweyn jiray in ka badan 10 maalmood u baahan yahay kormeerka wareegsan ee wareegga dhiigga durugsan. Si aad u baabi'iyo falcelinta aan loo baahnayn lagu jiro daaweynta u baahan tahay in la siiyo ilaa khamriga.

Overdosing waxyeellooyin

"Cefotaxime" analogues in ganaax ay leeyihiin tiro badan oo ah waxyeelo,

• dareen diidmo oo xasaasiyadeed (urtikaria, cuncun, finan, qandho, qarqaryo, bronchospasm, anafillaksiya, eosinophilia, anjioedema, necrolysis epidermal sun iyo Stevens-Johnson);
• dyspepsia (xanuunka caloosha, dysbacteriosis, yaaqyaaqsi, lallabo, matag, calool ama shuban, xanuunada ku dhaca beerka, marmar dhif ah - colitis pseudomembranous);
• glossitis, stomatitis,
• rabshooyin nidaamka hematopoiesis (hypocoagulation, anemia hemolytic, Torombositobiiniya, granulocytopenia, neutropenia, leukopenia);
• aan caadi ahayn ee xubnaha kaadida (kelyo interstitial, anuria, oliguria, azotemia, heerarka sare ee HOL ee dhiigga);
• wareer, madax-xanuun,
• geeddi socodka xun ee nidaamka wadnaha (garaaca siday khatar ku tahay nolosha);
• reactions maxaliga ah loo baahnayn (deyay, xanuun / m, phlebitis);
• isbeddel ah ee beegyada uu shaybaarka (been ah positive baaritaanka Coombs ');
• superinfection (candidiasis afka, candida vaginitis).

"Cefotaxime" analoogga ee daroogada marka loo isticmaalo qaabab sare waxay keeni kartaa in badinta, raaceen by gariir iyo calaamadaha kale, iyaga ka mid ah - walwalka, gariir, encephalopathy (marar aad u badan cudurka lagu arkay bukaanka ka cabanaya renal failure). Si aad u baabi'iyo saamaynta daaweynta badinta astaamaha waxaa loo isticmaalaa.

dhexgalka Drug daawooyin kale

Haddii aad u baahan tahay si aad u hesho hab la Halabuurka la mid ah sidiisa lacagtaas "cefotaxime" qaado analoogga ma noqon doonto adag. Laakiin arrinta ma, iyadoo la kaashanayo therapy daroogada waxaa la sameeyaa iyadoo la isticmaalayo analoogga asalka ama, kiis kasta, waxaad u baahan tahay inay tixgeliyaan dhexgalka ee daroogada lala qaato dawooyinka kale.

Marka "cefotaxime" khuseysaa labada daawooyinka laga yaabo nephrotoxic sida furosemide, antibiotics aminoglycoside, waxaa muhiim ah si ay u dhawraan shaqada kelyaha, sababtoo ah khatarta ah ee saameynta nephrotic.

Waayo, daaweynta cudurro badan oo looga hortago in ay horumarka inta badan isticmaalaan "cefotaxime". Tilmaamaha loogu isticmaalo, analogues daroogada ayaa in la bartay, sida qalab this keeni kara xasaasiyad, ayaa wax badan oo waxyeelo iyo qaababka kale. The xal of daroogada looma isticmaali karo in lala xal kale oo antibiyootig ah, ay aan la xiran karaa qolkii faleebo iyo saliingaha.

analogs

Macnaheedu for "cefotaxime" analog waa in la doortay walaxda firfircoon. Of analogues dhismaha la cayimi karo:

• sodium cefotaxime;
• waxay fijaankeedii ku cefotaxime, Sandoz, sodium iyo lek;
• tsefosin;
• tsefantral;
• tsefabol;
• tsetaks;
• tirotaks;
• tartsefoksim;
• taltsef;
• canshuur-to-dalab,
• spirozin;
• rezibelakta;
• oritaksim;
• oritaks;
• liforan;
• klafotaksim;
• klaforan;
• klafobrin;
• kefoteks;
• intrataksim.

Tan iyo markii ay jirto tiro balaadhan oo ah qalab loogu talagalay diyaarinta "cefotaxime" analog dooran fudud, laakiin t. Si aad. Analogs waxay leeyihiin waxaa laga yaabaa in waxyeelo kale, oo ay saamayn bogsiinta waxaa laga yaabaa in taagta daran, uu bedelay daroogada asalka ah waa in aad si taxadir leh u doortay. Si looga fogaado cawaaqib aan loo baahnayn, waa in ay bartaan macluumaad badan oo ku saabsan daroogada in la qorsheeyay in la isticmaalo.