"Azarga" (dhibco lagu shubo indhaha): tilmaamaha loo isticmaalo, qiimaha, iyo dib u eegis. Ma jiraa isha analoogga ah dhibcood ee "Azarga"?

ma daroogada "Azarga" (dhibco lagu shubo indhaha) Sidee? Tilmaamaha in habkan, waxyeelo ay, sababo iyo tilmaamaha loo isticmaalo in la soo bandhigi doonaa in this article. Intaa waxaa dheer, waxaad ku baran doontaa waxa uu leeyahay sifooyin pharmacological of this daroogada, sida iyo waxa qaadashada waa in la isticmaalaa, waxa dhici doona hadii aad iska badisid ah, iyo wixii la mid ah.

Form sii daayo daroogada maxaliga ah iyo qaab-dhismeedka

In waxa foomka waxaa bixisey in daawada farmashiyaha "Azarga"? Indhaha lagu dhibciyo - waa qaab kaliya ee sii daayo daroogada. 1 ml of daroogada ka kooban qaybaha firfircoon sida qaab maleate timolol in cadadka 5 mg oo brinzolamide (10 mg).

Sidoo kale waa in la ogaadaa in "Azarga" ayuu yiri medicament waxaa ka mid ah xubno ka kaabayaal ah. Kuwaas waxaa ka mid mannitol, disodium edetate, hydroxide sodium, chloride sodium, 50% chloride benzalkonium, tyloxapol iyo biyo la safeeyey. Waa laga helaa "Azarga" Dhibic ku shubtay walax of 5 ml.

Sifooyinka pharmacological of dhibcood

Waa maxay hantida ma daroogada "Azarga" (indhaha lagu dhibciyo), edbinta si kaas oo ku jira sanduuqa kartoonka wada jir ah ula daroogada? Sida kor ku xusan, medicament soo bandhigay ka kooban yahay 2 qayb weyn ee firfircoon. Waxaa timolol iyo brinzolamide. Arintaan waa inhibitor ah anhydrase carbonic II. Thanks in ay in jidhka bini'aadamka caanuhu formation of udhigo bicarbonate, oo markii danbe sodium iyo gaadiidka dheecaan hoos. nidaamka Tani waxay keenaysaa in hoos u dhac in wax soo saarka kaftan aqueous ee jirka ciliary biibiilaha muuqaalka. Tani waxa ay keentey in hoos u cadaadiska intraocular.

Sida timolol, ka dibna ay tani tahay a beta-xanibaha in aanu ka cadhaysiin habdhiska ah oo garawsi iyo ma joogsada muruqa wadnaha. Ka dib isticmaalka maxalliga ah, waxa ay yaraynaysaa formation of qoyaan iyo kordhiyaa ay soo qaxeen.

Pharmacokinetics daroogada

haddii daroogada la nuugo, "Azarga" (dhibco lagu shubo indhaha)? Tilmaamaha in habkaani bixisaa in isticmaalka mariyo qaybaha firfircoon sida brinzolamide iyo timolol, ay awoodaan in ay dhex gasho galay wareegga systemic. walaxda danbe la nuugo galay erythrocytes ka dib markii la xushay qabanaya si anhydrase carbonic II. Its ururka la borotiinada plasma waa qiyaastii 60%.

Brinzolamide metabolized by O-dealkylation, N-dealkylation iyo qayilo dhinaca N-propyl silsiladda. Waxaa la ogaan by kelyaha ee DASUURKA qadarkuu of 60%. Sayidka 20% waxay ka timaaddaa jidhka bini'aadamka sida metabolites.

muddo nuugid Timolol waa 5 saacadood ka dib isticmaalka la mariyo ee daroogada. shiid maalkii meel laba siyaabood: ethanolamine si ay u sameeyaan silsilado dhinaca on giraanta thiadiazole ah, iyo sidoo kale in ay sameeyaan kooxda ethanol nitrogen silsilad ah morpholine iyo kooxda carbonyl ah taas oo ku xiran nitrogen ah.

metabolites Timolol iyo sameeyay waxaa badanaa raaca via kelyaha. About 20% oo ka mid ah waxyaabaha la soo bandhigay qaab beddelin.

Tilmaamayaasha isticmaalka lacagta

Xaaladaha qaarkood, daroogada isticmaasho "Azarga"? dhibcood Eye loo qoondeeyay in lagu yareeyo kacsantahay cadaadis intraocular, kaas oo la ahbaa sabab u furi-xagal gulukooma. Sidoo kale, waxaa inta badan loo isticmaalaa in bukaanka qaba dhiig-karka indhaha ah. Laakiin tani waa keliya haddii monotherapy ayaa ku filan si loo yareeyo cadaadiska.

Sababo in loo isticmaalin lacagaha maxalliga ah

Mararka qaarkood, aad uma isticmaali karo daawada "Azarga" (dhibco lagu shubo indhaha)? Tilmaamaha qalab this ku qoran liiska caddaalad ah oo waaweyn oo ah sababo. hadda u fiirsada:

• kordhay dareen bukaan sulfonamides;
• neefta, oo ay ku jiraan taariikhda,
• Diidmo in qaybaha daroogada,
• cudurada sanbabada obstructive chronic, kaas oo ka dhici aad u adag;
• aysiidh hyperchloraemic;
• hyperreactivity bronki,
• diidmo in beta-blockers;
• bradycardia sanka,
• da'da carruurta (18 sano);
• AV-block II iyo III degree,
• nuujinta,
• wadnaha (daran);
• inta aad uurka leedahay,
• lama filaan ah cardiogenic;
• codsiga isku mar ah inhibitors (afka), anhydrase carbonic;
• rhinitt xasaasiyad, dal aad u adag;
• glaucoma xiro;
• kaafi kelyaha ee daran.

daawo taxadar qaadashada

Haddaba aad u ogaato, hoos leexashooyinkaasi kasta oo aan la talinayaa in la isticmaalo daawo, "Azarga". arjiga ku of guide qalab ku jira warbixin ku saabsan xaaladaha ay ku tahay in loo isticmaalo si taxadir leh u weyn. Liiskan waxa kujira, bukaanka qaba angina Prinzmetal, tayroodh, xadgudub oo ka mid ah bartamaha, xanuunada wareegga dhiigga durugsan iyo hypotension.

Sidoo kale waa in la ogaadaa in lagu daweeyo bukaannada qaba pseudoexfoliation iyo pigmentary qaadashada daawada gulukooma waa xaddidan. Xaaladaha noocaas ah, cadaadis intraocular waa in si joogto ah loola socdo.

Taxadarka u baahan tahay inuu ku meeleeyo daroogada si uu bukaan ficil-celintan jirka. Dhab ahaantii Tan waxa u sabab xaqiiqada ah in bukaanka sida helo beta-blockers, noqon adkaysi u qaadashada caadiga ah ee epinephrine ee daaweynta ee ficil-celintan jirka.

Sida kor ku xusan, brinzolamide iyo timolol awoodaan in ay ku mari nuugista systemic. Xaaladdan oo kale, ka kooban ugu horeysay waxay keeni kartaa waxyeelo si weelashii nidaamka, wadnaha iyo dhiig-mareenka. In xiriir this, waxaa lagu talinayaa in lala socdo xaaladda bukaanka ka hor iyo inta lagu jiro daaweynta.

Beta-blockers qoro si taxadir leh xad-dhaaf ah ee bukaanka qaba diabetes iyo janjeera in ay hypoglycemia. Tan waxa u sabab xaqiiqada ah in lacagtaas si fudud qarin karaan calaamadaha hypoglycemia ba'an.

Ka hor inta qalliin beta-blockers waa in loo joojinayaa baxay (2 maalmood). Indeed, inta lagu guda jiro suuxinta guud, ay awoodaan si loo yareeyo u nuglaanta myocardial in kicinta (dabacsanaadaan), taas oo muhiim u ah shaqada wadnaha yihiin.

Drug "Azarga" oo dib u eega lagu hoos lagu soo bandhigay doonaa, waxa ku jira brinzolamide taas oo sulfonamide ah. Marka la eego in isticmaalka mariyo dhacdaa nuugista systemic ee medicament ah, bukaan mariyo laga yaabaa in dhibaato in ay yihiin caadiga ah ee walxaha kuwan.

waxyeellooyin

Indhaha lagu dhibciyo "Azarga", qiimaha taas oo sare oo ku filan in ay kala duwan waxyeelo. Waxaana u faah faahsan u sharax dheeraad ah.

• bukaanka Local jawaabaan daroogada. In 10% ka mid ah xaaladaha bukaanka qaba hyperemia calaamadeysan conjunctival, nabaad corneal, isha qalalan, arag isku darsan, cun-cun oo ka mid ah xubnaha muuqaalka iyo dareenka jirka ajnabi ah. In 1% bukaanka lagu arkay keratitis punctate, dheecaan isha, conjunctivitis xasaasiyad, cuncun indhaha, indhaha xanuun, effusion qolkii jilibka ah, blepharitis, raaxo indhaha, qolof on cidhifyada xirribaha, erythema oo ka mid ah baalasha indhaha iyo il-dhaawac.
• waxyeelo systemic. In 10% ee kiisaska waxaa jira dysgeusia, iyo 1% - hoos u dhac ku cadaadiska dhiigga, hurdo la'aan, rhinorrhea, cudurada sanbabada chronic obstructive, koritaanka timaha oo yaraada, xanuun anitenatus, lichen planus ', iyo qufac.

Sidoo kale waa in la ogaadaa in walax firfircoon oo caynkaas ah, sida brinzolamide, waxay keeni kartaa kala duwanaansho soo socda: mydriasis, keratitis, barar indhaha, keratopathy, barar indhaha, in la kordhiyo kabxidda ee dareemayaasha optic ah, cyst subconjunctival, iin ah epithelium corneal, sclera midabka jirka, kor u kacay cadaadiska intraocular, korsiiya on wilka, isha dareen diidmo oo xasaasiyadeed, formation of cilladaha corneal, aragga, barar corneal, conjunctivitis, lacrimation kordhay, caabuq ku dhaca qanjidhada meibomian, isha hypoesthesia, aragga oo labalaabma, isha qalalan okonyunktivit, photophobia, pterygium, hoos toosan muuqaalka iyo photopsia. Ka mid ah waxyeelo systemic in la ogaadaa laga yaabaa in arxandarro, murugada, hoos u libido, dhantaalan xasuusta, qarow, cillad motor, somnolence, isku yaacsanaan, xusuus la'aan iyo xanuunada habdhiska dhimirka.

Wixii lagu daaweyn jiray saamaynta kasta oo kooxda la isticmaalayo daryeel taageero ah iyo calaamadaha. Waa in la isla markiiba ku maydhin indhaha biyo qabow.

Drug "Azarga" (indhaha lagu dhibciyo): Tilmaamaha

Qiimaha daroogada this waxaa laga yaabaa kala duwan, iyada oo ku xiran network farmashiyaha. Codso daroogada waa in la soo gudbiyaa degaanka kaliya. Ka hor inta isticmaalka, weelka waa in si xoog leh u rux.

In qiyaasta ah dhibcood ee "Azarga"? Tilmaamaha in habkaani ku jira macluumaad faahfaahsan oo ku saabsan mowduucan. Sida laga soo xigtay in ay, daroogada ay maamusho hal dhibic ah ee il kasta koleyga conjunctival. Si ay u fuliyaan hab this waa la jecel yahay in ay laba jeer maalintii.

Si looga fogaado horumarinta waxyeellooyin systemic ka dib markii la isticmaalayo daroogada waxaa lagu talinayaa in cadaadis farta light geeska hoose ee isha (aagga qiyaas ah kiish ku lacrimal ah). nidaamka noocan oo kale ah waa in ugu yaraan labo daqiiqo. Tani waxay si weyn u yaraynaysaa habka nuugista systemic.

Haddii isticmaalka daawada ayaa seegay, daaweynta waa in la sii on jadwalka la dose soo socda. At dose this kiis kasta waa in aan ka badnayn hal dhibic kasta koleyga conjunctival laba jeer maalintii.

Haddii ay sidaa tahay, haddii dhakhtarku bedelay daawada daroogada glaucoma ah "Azarga", waxaa lagu talinayaa in la isticmaalo oo kaliya maalinta ku xigta.

badinta

Currently wixii macluumaad ah oo ku saabsan xaaladaha ah qiyaasta xad dhaafka ayaa la soo sheegay. Si kastaba ha ahaatee, xaaladaha sida, waxaa jira ixtimaal ah waxyeelo kordhay.

Ganaaxyada marka la isticmaalayo daawada, dib u eegista

Waa maxay astaamaha leedahay indhaha lagu dhibciyo "Azarga"? comments Bukaan-socodka oo iyaga ku saabsan waa kuwo mugdi. Tusaale ahaan, in ka inhibitors waayeelka carbonic anhydrase, kuwaas oo afka ah loo isticmaalo, si toos ah saamayn ku yeelan kara kartida ay ku fulin karaan waxqabadka u baahan in korodhka isuduwidda ama dareenka. saamayn Tani waa in la tixgeliyaa marka uu u xilsaarayo daroogada si uu dhakhaatiirta.

In la isticmaalo la mariyo ee daroogada ee bukaanka xirtaan contact lenses, waxaa lagama maarmaan ah si ay ula socdaan xaaladda wilka. Tan waxa u sabab xaqiiqada ah in inhibitors anhydrase carbonic inta badan keenayso carqalad ah ay fuuq. Ka hor inta codsanaya siku ka dhigan tahay waxaa lagula talinayaa in ay ka saarto. dib rakib desirably ma hore ka badan ¼ saac isticmaalka daroogada ka dib.

Waxaa laguma talinayo inay taabtaan caaradda of dhalada in ay dusha kasta. Haddii kale waxaa dhici kara faddarayn. Ka dib isticmaalka dhibicleeyaha daawada waa in isla markiiba la xiray.

Dhexgalka daroogooyinka kale

Intee in le'eg oo waa isha lagu dhibciyo "Azarga"? Qiimahoodii waa mid qaali ah. Qaar ka mid ah silsilado farmashiyaha diyaarinta sida codsiga la mariyo waxa laga iibsan karaa 950-1050 rubles Ruush.

Iyadoo la isticmaalayo isku mar daroogada la inhibitors anhydrase carbonic afka (tus, daroogo "Diakarb", "Sulfadiurin", "Fonurit", "Glaupaks", "Dilamoks" iyo wixii la mid ah.) Waxaa laga yaabaa kordhin waxyeelo systemic.

Iyada oo taxaddar isu geeyo qalab la troleandomycin, ketokonazol, ritonavir, itraconazole iyo clotrimazole.

Waxaa jira faa'iido macquul talaabo hypotensive iyo deceleration heerka garaaca wadnahaaga helitaanka element firfircoon - timolol - la blockers channel calcium (tus, daroogo "Verapamil," "Amlodipine" "Diltiazem", iyo wixii la mid ah.), Beta-blockers, guanethidine, parasympathomimetics, glycosides wadnaha iyo wakiilada lagu daaweyn jiray garaaca wadnaha.

Dhimista in garaaca wadnaha lagu arkay iyadoo la isticmaalayo isku mar walxaha quinidine ama cimetidine.

gulucdooda Analog "Azarga"

Shiidaa daawooyinka oo dhan waxay leeyihiin analogues ay. Taasi waxay suurto gal ahayn in ay joojiyaan daaweynta cudurada jira xitaa ay ka maqan yihiin daawooyinka uu dhakhtarku soo qoro.

Waa maxay analoogga ee "Azarga" indhaha lagu dhibciyo waa ninka ugu fiican? jawaab cad su'aashan waa kuwo ku adag. Ka dib oo dhan, daawooyinka la mid ah waxay ku fiican yihiin in hab iyaga u gaar. Waxaa intaa dheer, waxaa laga yaabaa in ay leeyihiin a gebi ahaanba ka duwan waxyeelo iyo sababo. Sidaa darteed, ka hor inta codsanaya, hubi inaad la tashato dhakhtarkaaga.

Sidaas waxa la sameeyo haddii bukaanku uusan awoodin in uu ka iibsan indhaha lagu dhibciyo "Azarga"? analoogga ah qalab had iyo jeer waxaa laga heli karaa farmashiyaha. Si arrintan loo sameeyo, waa in aad xusuusataan oo kaliya magiciisa.

Sayidka, analoogga ah ee daroogada waxaa ka mid ah daawooyinka soo socda (indhaha lagu dhibciyo):

• "Teva-Timolol".
• "Timolol Oftan."
• "Inderal".
• "Duoprost".
• "Arutimol".
• "The EU Betalmik".
• "Timolol bufus".
• "Timadren".
• "Betoptik".
• "Timolol-Akos".
• "Betoptik C".
• "Timolol-DIA."
• "Betoftan".
• "Timolol-Lens".
• "Ganfort".
• "Timolol-Betalek".
• "Glautam".
• "Timolol-tuulo".
• "DuoTrav."

Waa maxay daawooyinka kale ee badali kara daawada "Azarga"? analoogga ah aalad waa in ay daruuri tahay waxaa ka mid ah sinji isla iniinahoodu ku dhex jiraan. Ka mid ah daroogada oo kale waa kuwa soo socda:

• "Timolol".
• "Betaxolol."
• "Timolol-MEZ".
• "Okupres-E."
• "Kombigan".
• "Okumol".
• "Ksalakom".
• "TimoGeksal".
• Eye Saliid "Oftan Timogel".
• "Ksonef".
• "Optibetol".
• "Niolol" gel isha.
• "Ksonef BC".
• "Timolollong".
• "Okuker";
• Indhaha lagu dhibciyo oo aan sheyga "timolol-tuulo".
• "Okumed" iyo wixii la mid ah.