"Atorvastatin": dib u eegista, analogs, halabuurka iyo tilmaamaha loo isticmaalo

Daawada ugu badan ee loogu talagalay in lagu yareeyo heerka kolestaroolka total iyo LDL waa "Atorvastatin". Kurtumm ku saabsan maqlana, inkastoo tayada wax soo saarka la xaqiijiyay by waxbarashada clinical. Isla mar ahaantaana daroogada wuxuu leeyahay mid kaliya tartan buuxa - "Rosuvastatin" (oo xabbo ay). Sababtoo ah waa wax iska cad in ay "atorvastatin" diyaarinta Kurtumm bukaanka laga yaabaa in aan ku siiyo macluumaad Ujeedada. Sidaas daraaddeed, si ay u qiimeeyaan saamaynta ay loo baahan yahay falanqeyn faahfaahsan ee hab ay of action iyo qodobada ka mid ah tilmaamaha ku lifaaqan si ay u isticmaalaan.

soocista walax daroogada systemic

Atorvastatin iska leh fasalka pharmacological jiilka saddexaad statins. By anada enzyme mas'uulka ka ah ereygu wuxuu qoomiyadda of kolestaroolka, oo yaraynaysa xaddiga jajab lipoprotein atherogenic. jajab Low-cufnaanta (LDL) kobcin karaan dhigaalka oo kolestarool ah iyo sababi jawaabaha difaaca ee endothelium ah, taas oo ay sabab u tahay huurada soo koraya.

Like statins kale, atorvastatin si weyn u yaraynaysaa qadarka LDL, oo sidaas daraaddeed si weyn loogu talla koritaanka huurada. In janjeera si ay u noqoshada aan arkay, iyo dhexroor ee halbowlaha ah coronary (ama atherosclerotic kasta oo kale), isku mid. Saamaynta clinical - hoos gaabis horumarinta cudurka wadnaha, cerebrovascular ahaan ama halbowlaha chronic ah addimada hoose.

"Atorvastatin": muujinaya in loo isticmaalo

Ka hor qabsashadii ayaa loo baahan yahay si ay u qeexaan muujinaya ee isticmaalka daroogada. Waxay yihiin oo ka soo jeeda hab ay aasaasiga ah ee ficil iyo xiriirka la leh saamayn cholesterol-hoos ah. Range of tilmaamo:

• dhaxlo hypercholesterolemia (qoyska), heterozygous;
• polygenic (hoose) IIa fasalka hypercholesterolemia sida ay Fredrickson;
• Iskujira (IIb) dyslipidemia;
• hypercholesterolemia qoys Homozygous;
• hypertriglyceridemia (daawaynta statin isku dhafan oo cuntada iyo jimicsiga);
• xaaladaha la xidhiidha lesions atherosclerotic vascular oo ka mid ah derbiga wadnaha, maskaxda, kelyaha, jirka,
• hypertension halista sare wadnaha;
• ka hortagga dhacdooyinka coronary ba'an ka dhanka ah asalka ah lesions jira atherosclerotic of halbowleyaasha wadnaha;
• ka hortagga myocardial dib-u-Wadnaxanuun ama stroke cerebral.

akhrinta Kuwani qaadista dacwadaha marka waxaa loo baahan yahay magacaabidda "Atorvastatin" daroogada. Dhakhaatiirta ku saabsan codsigaaga si cad u xaqiijin baahida this. Waxaa xaqiiqo ah oo la xaqiijiyay in statins, oo ay ku jiraan "Atorvastatin" la xabbo ay tiro badan yihiin kardioform badan ammaan acetylsalicylic acid, inkastoo sidoo kale kaa caawin in ay si weyn u yareeyo suurtagalnimada of horumarinta xaaladaha Wadnaxanuun iyo celiyaan myocardial ugu horeysay.

analogues daroogada

Dhammaan kiniiniyada "Atorvastatin", taas oo u eegay hoos loo akhrin karaa, soo saaray shirkadaha dawooyinka kala duwan. Inta badan, magacyada daawooyinka waxaa modified, taas oo u ogolaanaysa in la xiranayo. magacyada Trade analogues, taas oo ah, daawooyin ay ku jiraan atorvastatin sida qayb firfircoon, waxa soo socda: "Anvistat" iyo "Atokord", "Atomas" iyo "Ator", "Atorvoks" iyo "Atoris", "Vazotor" iyo "Lipoford" "Lipitor" iyo "Liptonorm", "Novostat" iyo "Torvazin", "Torvakard" iyo "Tulip".

Sidoo kale, saarayaasha qaar ka mid ah soo saaraan ay daawada "Atorvastatin" (waxaad ka akhriyi kartaa dib u eegista hoosta) ka yar isku magaca ganacsiga. "Actavis", "Vertex", "Izvarino Pharma", "ALSI Pharma", Obolentsenskoe shirkadda dawooyinka "Canon Pharma", "Protek-SVM", "North Star", farxeen Daawooyinka, TEVA Pharmaceutical Industries, iyo kuwa kale oo ay soo saaraan magaca daroogada taas oo ka kooban INN ah ( "atorvastatin") iyo consoles'ka dhaqanka. Tusaale waxaa ah "Atorvastatin Teva", dib u eegista ah kuwaas oo xaqiijin ay waxtarka bukaan ah.

Qaab-dhismeedka

Lifaaqsan daroogada tilmaamaha 'atorvastatin' loo isticmaalo, dib u eegista iyo tilmaamo caafimaad oo ha ku jira macluumaad ku saabsan farqiga u dhexeeya foomamka qiyaasta. In dhaqanka, kala duwan sida jiraan, oo ay sharci u dhaqdhaqaaqa ficilka-ku-daweyn. Waxa muhiimka ah waa sida ay si deg deg ah ku yimaado saamaynta ku daweynta ee qiyaasta. Taasi waa sababta dejinta "Lipitor" waa tixraac ah ee daroogada asalka ah.

foomka qiyaasta ka kooban kiniinno calcium atorvastatin iyo qolof. Arintaan, markeeda, waxay ka kooban tahay carbonate calcium, cellulose mikrokristallin, laktosmonohydrat lactose, polysorbate 80, croscarmellose sodium, milmahayn magnesium, hydroxypropylcellulose, Rusheyn kartaa, titanium dioxide, tones polyetylen, hydroxypropylcellulose, emulsion simetikonovoy, Benzosyrene iyo sorbic acid.

Ku lifaaqan buugan asalka daroogada "Atorvastatin" edbinta (oo sidoo kale on markan dib u eegista) kuma jiraan macluumaad ku saabsan miisaanka qayb kasta. Tani waa sir ah ganacsiga shirkadda American Pfizer HCP KAMBANI. Noocan oo kale ah qaab qiyaasta "Lipitor" oo noo ogolaadaa in ay gaaraan fiirsashada joogta ah atorvastatin ee dhiigga.

Isugeynta foomka "atorvastatin"

In diyaarinta "Atorvastatin" qiimaha (Kurtumm bukaanka u xaqiijin) waa ay heli karaan tiro balaadhan oo ah bukaan. Waa daawo xad ammaan ah in lagu dari karaa fasalo kale ee daroogada. Inta badan, "atorvastatin" iyo statins kale waxaa la soo saaray ee go'doomin, in uu yahay, in mid ka mid ah kiniin waa mid ka kaliya ee firfircoon. Si kastaba ha ahaatee, waxaa jira noocyo isu geeyey.

Tusaalayaasha waxaa ka mid ah daroogada ee soo socda: "Kaduet", "Duplekor", "statins". Halkan, "atorvastatin" waxa la xidhiidha amlodipine, xanibaha calcium channel ah, kaas oo sidoo kale inta badan loo isticmaalaa in lagu daaweeyo cudurrada wadnaha. qiyaasta of daroogada la doortay dhakhtarka.

qiyaasta Standard "atorvastatin"

Drug "Atorvastatin", tilmaamo, tixraacyo iyo talooyin ku saabsan isticmaalka daaweynta oo aan tixgelin doonna in our dib u eegista, waxaa laga heli karaa saddex qaadashada caadiga ah: 10, 40 iyo 20 mg. Isku diyaarinta "Kaduet" ka kooban yahay 10 mg ah atorvastatin iyo amlodipine 5. "Statins" waxaa la soo saaray ee laba nooc: 10/5 iyo 10/10 mg. In diyaarinta "Duplekor" 4 qiyaasta of atorvastatin iyo amlodipine: 10/5, 10/10, 20/5, 20/10 mg. Tani waxa ay yaraynaysaa tirada kiniinka ah in bukaanka qaba in ay isticmaalaan iyo statins iyo blockers calcium channel for daawaynta cudurada. Taana waxaa lagu gaarayaa iyo hoos u dhac in kharashka daaweynta.

Doorashada "atorvastatin" u gaar ah

hab First ka kooban atorvastatin qabtay sale waa "Lipitor". Tani waa dawo asalka ah, kaas oo ay fuliyeen imtixaanada. Later waxaa kaloo jiray daroogooyinka kale hoos magacyada kale. Waayo, diiwaangelinta loo baahan yahay oo kaliya xaqiijinta rasmi ah bioequivalence "Lipitor." Waqtigan xaadirka ah, waxaa ku faani karo of a saarayaasha yar. Sidaa darteed, helitaanka warqad dhakhtar ee daroogada ee hadda jira "Atorvastatin" analogues ee dib u eegista waa in si taxadir leh loo soo bartay.

Inta badan, dhakhtarka ku talinaysaa daroogada ayaa la xaqiijiyay bioequivalence "Lipitor" oo uusan saamayn ku tilmaamay in tilmaamaha ku lifaaqan. Qiimaha "Lipitor" waxaa laga heli karaa, ma aha adag tahay si ay u bartaan for dawayn. Si kastaba ha ahaatee, waxa aan la qoray in bukaanka qaba xarumaha hadda jira ay sabab u tahay cudur caadi ah naafada. Xaaladdan oo kale, kuwa daawooyinka laguu qori karaa concessional gacanta Xarunta baaritaanada iyo tijaabooyinka ee daawada. Waxtarkooda ayaa sidoo kale cadeeyay.

Kurtumm ku saabsan "atorvastatin"

On diyaarinta "Atorvastatin" dib u eegista bukaan kasta ma noqon karo karti, sababtoo ah iyada oo aan lagu qiimeeyo profile la egyahay suurtogal ma aha in saamaynta maandooriyayaasha xukumi. Sidaa darteed, si loo hubiyo ku-oolnimada, waa in ay u falanqeeyaan isbedelka jajabyada la egyahay. Waxaa intaa dheer, wax kasta oo "Atorvastatin", dib u eegista ah ee ku jira tiro badan, waxay bixisaa macluumaad ku saabsan dhibaato. The ugu caansan waa saamaynta xasaasiyad. Sumoobo waa yar yahay iyo inta shucaaca dismo. Si kastaba ha ahaatee, haddii ay dhacdo wax kasta oo muuqaalka kore ee cytolysis syndrome iyo in transaminases praktik u baahan tahay ka saarida daroogada.

Bukaan-socodka ayaa sheegaya in saamaynta sun ah waa dhif iyo naadir. Sababtan darteed, dad badan oo buka waxaa lagula talinayaa in ay isbarteen daroogada ama qaraabo, inkasta oo caga loo baahan yahay wada tashi caafimaad, qiimeynta khatarta iyo go'aan jajabyada of subaga dhiiga. Intaa waxaa dheer, dad badan oo daroogada guryaha jiritaan la'aanta loo xilsaaray, tusaale ahaan, in uu awoodo in uu yareeyo miisaanka jidhka.

Laakiin aragti dhaw at baahida loo qabo in ay leeyihiin xad "Atorvastatin" dib u eegista daroogada. waxaa Slimming ma ku habboon yahay, oo kaliya loo qaadan karaa in lala xamuulka iyo cunto. Isugeynta isticmaalka "atorvastatin" iyo kuwa kale ee wakiilada la egyahay-hoos, sida waxaa inta badan lagu talinayaa in shakhsiyaadka aan tababar caafimaad, waxay keenaysaa in rhabdomyolysis iyo sumoobo beerka.

Reviews dhakhaatiir ah oo ku saabsan daroogada

On diyaarinta "Atorvastatin" dib u eegista uu dhakhtarku ka muhiimsan yahay dib u eegida bukaanka. Isla sidaas u dhaqmaan daroogooyinka kale. Guud ahaan, dib u eegista oo dhan khubaro abstracts sifaha ammaanka daroogada iyo waxtarka. Waxay yaraynaysaa kolestaroolka total iyo LDL, halka laga kordhinayo HDL. Tani waa mid aad u muhiim ah, sababtoo ah waxaa aad u ogolaanaya in la xakameeyo koritaanka bakteeriyada qurunta atherosclerotic, iyo dib u dhigto bilawga Wadnaxanuun myocardial.

Dynamics saamayn hypocholesterolemic in "Atorvastatin" diyaarinta (eegis lagu shiidaa dhakhtar kasta oo Xaqiijiyay) waa mid aad u tilmaan. Caadi ah profile la egyahay serum waxaa lagu gaarayaa 1.5-2 bilood gudahood. The "rosuvastatin" waxaa lagu gaarayaa 30-50 maalmood gudahood. Si kastaba ha ahaatee, halka "atorvastatin" Baaritaanadii caafimaad oo dheeraad ah si ay u taageeraan oo ay ku oolnimada iyo ammaanka. Guud ahaan, waa kuwan laba daroogada wanaagsan, mid kasta oo loo isticmaali karaa daaweynta hypercholesterolemia iyo prophylaxis cudurada wadnaha.

qiimaha dawooyinka

daroogada "Atorvastatin" Qiimaha (dib u eegista badan oo ku saabsan svidelstvo this) kala duwan taas oo ku xidhan soo saaraha. The ugu qaalisan yahay "Lipitor" - daroogada asalka ah. kharashka daaweynta Bisha waa 900-1100 rubles marka la helo qiyaas ah 40 mg. At qiyaasta maalin kasta kharashka daaweynta 20 mg waa 800-900 rubles. Generic "Lipitor" waa wax badan ka jaban.

Qiimaha daaweynta bil kasta "Atoris 40 mg" 500 rubles, halka helaya 20 mg - 200 rubles. The "Atoris" - waa bioequivalent "Lipitor" daroogada, si buuxda u bedelida. Sidoo kale waxaa jira daawooyin ka jaban, "Torvakard" "Lipitor", "Torvas" kharashka daaweynta bil dose maalinle ah oo 40 mg 300 rubles jaban. Iyo qiimaha daaweynta la dose maalinle ah oo 20 mg noqon doontaa 100-150 rubles.