Ursodeoxycholic acid: tilmaamaha loo isticmaalo, analogs, dib u eegista

Recently, waayo, daaweynta ee lesions kala duwan beerka waxaa sii kordheysa loo isticmaalay ursodeoxycholic acid. Tilmaamaha loogu isticmaalo ee xarunta kiimikada oo tilmaamaysa in ay ku oolnimada in cuduro badan oo khatar ah. Waa maxay walax this? Waa maxay ursodeoxycholic acid? In waxa soo saarka oo waa hadiyad?

description

Ursodeoxycholic acid, isticmaalka kaas oo ku salaysan yahay in ay asal ahaan iyo guryaha, waa budo cad-jaalle ah crystalline. Waxay leedahay dhadhan qadhaadh. walax Tani waa in si caadi ah u shaqeeya u shaqeeyo aadanaha waxaa soo saaray tiro yar. Its cuf gaar ah wuxuu ku saabsan yahay 5% miisaankiisa wadarta guud ee acids bile. Waa hydrophilic oo uu leeyahay cytotoxicity lahayn. xarunta kiimikada Tani waa L. in khamriga iyo glacial acetic acid, in yar L. ee chloroform iyo ku dhawaad beelaya biyo. Ursodeoxycholic acid aan ku jira badeecada. Waxa la ogaaday in xameetida orso ka brown.

Ursodeoxycholic acid (UDCA) waa epimer ah chenodeoxycholic acid. Markii hore waxa loo adeegsaday oo lagu daweeyo gastritis reflux iyo soosaaray qaybsama. Waqti ka, waxay bilaabeen inay in la isticmaalo, iyo in cuduro kale oo badan. UDKH tixgeliyo ugu ammaan ee acids bile.

Saamaynta of ursodeoxycholic acid

Si aad u taariikhda, isticmaalka UDKH waa therapy caadiga ah cudurka kala duwan beerka cholestatic leh qayb ah, shalalka. hab ay of action ah wakiilka waa in la xasiliyo unugyada jirka ah. taagoo Its loogu dhex dari karaa xuubka unugyada beerka - hepatocytes. Sababtoo ah waxay awoodaan si aad u adkaysi u arrimood xoqe yihiin. Wakiilka Tani hepatoprotective leedahay saamayn choleretic. UDKH yareeyo Avv kolestaroolka beerka iyo ka hortagtaa ay nuugista ee xiidmaha. daroogada Tani waxay hoos u dhigtaa oo kiciyaa lithogenicity content bile acid dhexdeeda. Waxa ay wanaajisaa waxqabad ee lipase, ganaca iyo dheecaan gastric. Ursodeoxycholic acid uu saameyn ku hypoglycemic iyo dareen ku formation iyo kala bile, waxay yaraynaysaa kolestaroolka.

daroogada Tani janjeero cholesterol qayb ah ama buuxda oo dhagaxyo kolestaroolka. Taasi waa sababta ay waxaa loo isticmaalaa marar badan. Xiriirka lala kolestaroolka, waxay kordhisaa milmi ee kiristaalo ay, taas oo deleteriously u dhaqmo on soosaaray. UDKH ayaa tallaabo immunomodulating taas oo ah in la kordhiyo hawlaha lymphocyte ah, yaraynaysaa muujinta cudur oo kala duwan oo ku saabsan xuubka of hepatocytes. Wuxuu saameeyaa tirada T-limfosaytis, yaraynaysaa tirada eosinophils.

UDKH yaraynaysaa fiirsashada oo kolestarool ah ee bile ay kala firidhsan iyo kala guurka ah walaxda in waji crystal dareere ah. Wuxuu saameeyaa wareegga enterohepatic of bile cusbada. Sidaas darteed of this hoos loo nuugay mindhicirka xeryahooda hydrophobic iyo sun qoomiyadda. daroogada waxa uu leeyahay hepatoprotective si toos ah iyo saamayn choleretic. Ursodeoxycholic acid, kaas oo dib u eegis ku of takhasusay hepatology muujiyaan ay ku oolnimada, waa awood yaraynta fibrosis beerka ee xumaanshaha dufan ay.

codsiga

Ursodeoxycholic acid, kaas oo codsi loo sameeyaa iyada oo ay kormeerayaan dhakhtarka xaadirka ah waxa lagu qoray at xaaladaha cudur sida:

• jiritaanka dhagaxyo kolestaroolka kooban in kaadi haysta ama koollo caadi ah;

• Awood la'aanta in endoscopically ama qalitaan lagu daaweeyo;

• chronic, atypical, oo ba'an hepatitis, shalalka ,

• jiritaanka dhagaxyo kolestaroolka ka dib markii lithotripsy farsamo iyo extracorporeal;

• sun (daroogada, aalkolada), dhaawaca beerka;

• cholangitis sclerosing;

• cirrhosis biliary aasaasiga ah, oo aan lahayn calaamadaha decompensation;

• atresia, mareenka biliary;

• cystic fibrosis;

• hepatitis firfircoon chronic;

• cholestasis inta lagu guda jiro nafaqada parenteral;

• Tardive biliary;

• biliary syndrome dyspeptic la Tardive biliary iyo holetsistopatii;

• opistorhoze chronic;

• atresia biliary dhasho;

• esophagitis reflux biliary iyo gastritis reflux.

Ursodeoxycholic acid (UDKH) ee loo isticmaalo ka hortagga dhaawaca beerka laaluusheen by maamulka nudaha iyo uurka hormoonnada ah. Waxaa lagu qoray, waayo cudurada kale ee ay keento fadhiidka ah ee bile. UDKH qoondeeyay therapy Curiyaha taageerada ee badalida beerka ama xubin kale.

sababo

Ursodeoxycholic acid, kaas oo dib u eegis ku qaybta ugu wanaagsan, wuxuu leeyahay sababo halis ah. Kuwaas waxaa ka mid ah:

• cudurada bararka ee xameetida, xiidmaha iyo marinnada bile ee wajiga ba'an;

• soosaaray rentgenopolozhitelnye la content calcium sare;

• xanibaadii mareenka biliary;

• diidmo;

• cirrhosis lagu jiro decompensation;

• cudurka Crohn;

• khaladaad loogu dhawaaqaa in hawlaha ka mid ah xameetida, beerka iyo kelyaha.

xadeynta isticmaalka

Ursodeoxycholic acid, tilmaamaha loo isticmaalo kaas oo si cad u muujinaysaa maqan yahay xadeynta adag ee ay codsiga, ma waxaa ilmaha loo qoondeeyey ilaa 3 sano qaab kaabsal. Waayo, isticmaalka daaweynta slurry ka kooban walax daroogada this. Ilaa iyo hadda, khubaro aan la sameeyay waxbarashada ku habboon loogu talagalay go'aaminta saamaynta cholelitolitic walax this xiran tahay da'da ilmaha. Isla mar ahaantaana, waxbarashada sameeyey joogaan carruurta la atresia biliary iyo cudurada beerka qaarkood aan muujiyeen dhibaatooyinka carruurta gaar ah.

Diyaargaraw ka kooban ursodeoxycholic acid, la siiyo haweenka uurka leh oo keliya marka saamaynta loogu talagalay therapy wakiilka this waa ka weyn yahay khatarta ka iman karta in ilmaha aan weli dhalan. Waa in aynaan illoobin in baadhitaan buuxa sayniska ee ammaanka kiimikada for this category ka mid ah bukaanka waxaa qofna qaatay. Tan lama yaqaan in UDKH guskiisa galay caanaha naaska, taxaddar loo baahan yahay in magacaabidda daroogada si uu dumarka lagu xanaaneeyo.

waxyeellooyin

acid Ursodeoxycholic, tilmaamaha loo isticmaalo taasoo muujinaysa ma aha oo kaliya xadeynta ee ay codsiga, laakiin sidoo kale in waxyeelo ay suurtagal tahay, waxay keeni kartaa in ay ifafaale bahal ah sida:

• calool, shuban,

• lalabo,

• transaminases kordhay,

• xanuun Rubuca sare midig iyo gobolka gaastari;

• Dareen-celinta xasaasiyadeed maqaarka (cuncun, finan);

• dhagaxyo calcining.

Daaweynta hoose cirrhosis biliary diyaarinta this mararka qaarkood keentaa in bukaan-socodka uu leeyahay decompensation meel, iyo baaba 'ka dib bixitaanka qaata daroogada this.

tallaabooyin taxaddar

Si aad si guul leh litholysis dhagaxyo kolestaroolka isticmaalaya UDKH u baahan yihiin inay tixgeliyaan shuruudaha soo socda:

• ay size ma aha in ka badan 2 cm,

• iyagu ma ay siin hadh on radiograph ah;

• kaadi haysta waxaa sida caadiga ah oo shaqeynaya;

• marinnada ilaaliyaan patency;

• xumbo a dhagaxyo yar ka badan kala badh ka buuxsamay,

• koollo u bile caadi ma dhagaxyo aan ku jira.

Maxaa xayiraad kale oo ku saabsan gelitaanka waa ursodeoxycholic acid? Tilmaamaha in this diyaarinta caafimaad muujinaysaa in daaweyn muddada dheer, waa in ka badan 1 bil oo, waa in ay ahaadaan si joogto ah (1 30 maalmood oo kasta) loo sameeyo korjoogteynta ee transaminases cagaarshowga, phosphatase, bilirubin, gamma-glutamyl dhiig transferase. Samaynta falanqayn sida si gaar ah muhiim in 3dii bilood ee hore ee daaweynta la UDKH. Saamayntii daaweynta waxaa xaqiijiyay X-ray lixdii biloodba mar iyo bile ultrasound. Waayo, ka hortagga ku xoogeystay of qalal sii daaweynta cholelithiasis iyo ka dib kala diridda dhamaystiran oo dhagaxyo. Waxay qaadan kartaa bilo badan.

Inta lagu guda jiro daawaynta UDKH haween ku jira da'dii dhalmada lagu talinayaa in la isticmaalo habab lagu kalsoonaan karo oo ah ilaalinta uurka. Waxaa laga yaabaa in dawooyinka aan ahayn hormoon ama uurka ku jiraan xaddi yar oo ah estrogen.

foomka Release iyo qiyaasta

Ursodeoxycholic acid, by kaas oo diiwaanka siinaysaa tilmaan faahfaahsan oo circuitry soo dhaweynta ay, waxaa la soo saaray foomamka qiyaasta sida:

• kaabsoosha oo loox ee 150 iyo 250 mg,

• ganaax carruurta.

Qiyaasta UDCA adag dhigay shaqsi ahaan. Waxay ku xiran tahay darnaanta xaaladda insaanka iyo miisaanka jidhkiisa. Xaaladaha intooda badan, waxaa la qoray by 10-20 mg / kg maalintii. dose Tani waxa laga soo qaatay hal mar, fiidkii. Muddada daaweynta ku xiran yahay caddeynta ah. daroogada Tan waxaa lagu nuugo xiidmaha yar, iyo 3 saacadood ka dib plasma waxaa lagu xusay in ay fiirsashada ugu sareeya. medicaments dhaweynta Constant kooban ursodeoxycholic acid, waxaa acid ee bile hoose ee jidhka bini'aadamka ka dhigaa. Qoraalkan waxaa la hoos geliyey noocyo kala duwan oo transformations iyo natiijada kama dambaysta ah waa wax soo saarka sida metabolites ee saxarada iyo kaadida.

Duration daaweynta waxaa lagu go'aamiyaa uu dhakhtarka xaadirka ah. Waxay noqon kartaa kala duwan taas oo ku xidhan nooca cudurka. Xaaladaha daran qaar ka mid ah, soo dhaweynta daroogada UDKH socdaa muddo sanado ah.

Dhexgalka daroogooyinka kale

In soo dhaweynta si wadajir ah iyo UDKH "Cyclosporine" korodhka la saadaalin karin nuugista ee dambaysta ah. In plasma u xuub-kordhiyaa-fiirsashada ee diyaarinta, daawooyinka. Marar dhif ah soo dhaweynta UDKH isku diyaarinta "Ciprofloxacin" fiirsashada ee la soo dhaafay hoos.

Ursodeoxycholic acid (analogues)

acid Ursodeoxycholic (kaabsoosha, kiniin) macmalay hoos magacyo kala duwan. wakiilada noocan oo kale ah ku kala duwan yihiin excipients galay ay Halabuurka. Sayidka, suuqa la kulmi kartaa daawooyinka la ursodeoxycholic acid:

• kaabsoosha "Ursosan" loogu therapy cudurka beerka waajihi, cholelithiasis, la gastritis biliary reflux iyo esophagitis reflux, cirrhosis aasaasiga ah, daroogada iyo dhaawaca beerka sun ah, cholecystectomy, cudurka khamriga, cholangitis sclerosing, atresia Biliary, steatohepatitis nonalcoholic. Ursodeoxycholic acid ( "Ursosan") waxaa loo isticmaalaa ka hortagga lesions beerka.

• Kiniiniga "Ukrliv" qaata ee kala dhantaalan, cagaarshowga, hepatitis chronic, cholelithiasis.

• kaabsoosha "Ursofalk" sharaxan kala duwan cudurada ka mid ah kaadi haysta iyo beerka, Ulasocto cholestasis, hoos u dhac of qaar ka mid ah beerka, heerka kolestaroolka kacsantahay. Kuwaas waxaa ka mid cirrhosis hoose biliary iyo cholangitis sclerosing, gastritis reflux iyo esophagitis reflux, hepatitis of etiology kala duwan, dhagaxyada kolestaroolka, cystic fibrosis, lesions kala duwan ee beerka, Stasis bile. diyaarinta waxaa loo isticmaalaa sida profilatikada ee looga soo horjeedo dhaawac beerka marka la helo daawooyin awood.

• Kiniiniga "Ursodeks" Yeeshay at cirrhosis biliary aan calaamadaha decompensation iyo gastritis reflux. Waxay waxaa loo isticmaalaa si ay u milmaan dhagaxyo kolestaroolka yar ee hawlaha caadiga ah ee xameetida.

• kaabsoosha "Ursodez" loo isticmaalaa in lagu dumin dhagaxyo kolestaroolka, daaweynta gastritis reflux, waayo, daaweynta ee astaamaha for cirrhosis aasaasiga ah ee beerka oo aan lahayn calaamadaha decompensation.

• kaabsoosha "Ursolizin" sharaxan kala diridda dhagaxyo kolestaroolka, iyo daaweynta calaamadaha of cirrhosis biliary, cholesterosis kaadi haysta iyo gastritis reflux. Daawada waxaa loo isticmaalaa in therapy isku dhafan bukaanka qaba hepatitis chronic iyo cirrhosis.

• kaabsoosha "Choludexan" loo isticmaalo daweynta ee cholelithiasis badnayn, hepatitis firfircoon chronic, lesions beerka khamriga iyo sun ah, steatohepatitis nonalcoholic, hoose cirrhosis biliary, cholangitis sclerosing hoose, cystic fibrosis, Tardive biliary, gastritis reflux iyo esophagitis reflux.

• kaabsoosha "Urdoksa" in loo qoro ee aasaasiga ah cirrhosis biliary, oo aan lahayn calaamadaha decompensation, gastritis reflux. daroogada waxay ahayd si fiican u kala diray dhagaxyada yaryar iyo kuwa dhexdhexaadka kolestaroolka, iyadoo la ilaalinayo shaqada caadiga ah ee xameetida.

• kaabsoosha "Kursorka C", qorin cholelithiasis badnayn, cirrhosis hoose, ba'an iyo hepatitis chronic, cholangitis sclerosing, atresia mareenka intrahepatic, gastritis reflux iyo esophagitis reflux, cholestasis, inta lagu guda jiro nafaqada parenteral, Tardive biliary, cudurka beerka, la cystic fibrosis, gepatoze baruurta, syndromes dyspeptic. diyaarinta waxaa loo isticmaalaa ka hortagga dhaawaca beerka ee isticmaalka uurka hormoonnada ah iyo kuwa nudaha, formation dhagax ku cayilka.

Ursodeoxycholic acid, analogs ee wax this waxaa laga qaadaa qoray oo kaliya dhakhtar.