Drug "Sotageksal", analogs iyo jawaab-celinta iyaga on

Arrhythmia - waa nooc ka mid ah garaaca wadnaha, taasoo ka laxanka caadiga ah sanka kala duwan. Marka garaaca in aadanuhu uu jiro hal ama dhowr xadgudubyada waxyaalaha qalbiga ku jira. cudurradana laga yaabaa in ay soo bandhigaan sida heerka a noqnoqoshada iyo awooda cod wadnaha (tachycardia) iyo, taas bedelkeeda, hoos u dhac in ay (bradycardia). Khalkhal shuqulkii muruqa wadnaha iyo waa in qof caafimaad qaba. Si kastaba ha ahaatee, kiisaska intooda badan, arrhythmia waa in lala cudurada kale ee wadnaha. xaalad noocan oo kale ah waa halis ee in excitability kordhay ee unugyada wadnaha - myocardium, taas oo keeni karta ugu danbeyn si wadnaha oo shaqadiisa gaba haddii aan la daweyn.

waxaa jira diyaarinta gaar ah caadi u ah garaaca wadnaha, mid ka mid ah taas oo ah "Sotageksal". Analogues daroogada ayaa sidoo kale si weyn loo isticmaalaa in ku dhaqanka caafimaad. Daawooyinkan waxaa iska leh koox ka mid ah daawooyinka in ay leeyihiin hawl antiarrhythmic, iyo beta-blockers. Marka daama, waxay xannibi receptors beta-adrenergic ah, kuwaas oo ku yaalla muruqa siman ah, muruqa wadnaha iyo unugyada kale, oo masuul ka ah wax ka qabashada jirka ee saamaynta walaaca jira. kardioeffekt Guud ahaan waa in la yareeyo inta jeer iyo xoojinta of garaaca wadnaha, hoos u tabinta wadnaha. Sida saamayn systemic waxaa sidoo kale lagu arkay hoos u cadaadiska dhiigga on darbiyada weelashii wadnaha.

daroogada

"Sotalol» (Sotalol) - qaateen magaca caalamiga ah ee dunida ka mid ah daroogada "Sotageksal". Analogs ka kooban ayaa laga yaabaa in saameyn kala duwan, laakiin isku mid ah antiarrhythmic. The walax ugu weyn ee firfircoon "Sotageksal" waxaa ku jira hydrochloride sotalol. Intaa waxaa dheer, waxaa ka mid ah tirada yar oo ka kooban kaabayaal ah. iyaga ka mid ah, - cellulose, laktosmonohydrat lactose, istaarijka galley, milmahayn magnesium iyo galalka kale.

Nolosha shelf ah kiniin ama xal isku duro waa 5 sano.

analogues "Sotageksal" iyo Curiska

Mid ka mid ah kiniin oo ah alaabta this ka kooban yahay 40, 80 ama 160 mg oo ah walaxda firfircoon. Waxaa la soo saaray inta badan sida kiniinno wareega White oo hal dhinac uu wax yar ka convex iyo gadaaman la Sot gaabiyay ah. Dhinaca dambe ee kaniiniga waxaa bisected by yahay ee keeneysa in sahlaansashada khataraha. All buuxiyey oo ku yaal finan of 10 xabbadood, iyo kartoonada. xidhmo kasta u dhaxayn kartaa 1 ilaa 10 finan (ee ka soo 10 ilaa 100 xabbo oo kiniin).

Sidoo kale, "Sotageksal" waxaa la soo saaray ee foomka of xal la isku duro xididka. dhalada kasta waxa ku jira 4 ml of daroogada. In 1 ml of xal waa 10 mg oo ah walaxda saafi aasaasiga ah. Daawada waa in laga ilaaliyo qorraxdu si mugdi iyo meel qalalan, taas oo carruurtu ay heli karaan waa xaddidan.

Analogs la sotalol firfircoon walax kiniin hydrochloride waxaa soo saaray:

• "Sotaleks" (160 mg).
• "Soritmik" (by 0,16 g).
• "Sotalol Canon" (80 iyo 160 mg).
• "Darob" (80 iyo 160 mg).
• "Tenzol" (80 iyo 160 mg).

saamaynta pharmacological

"Sotageksal" analogues iyo micne ah ee daroogada ku leeyihiin saamayn anti-arrhythmic fahmayaan. Taana waxaa lagu gaarayaa by Samo falku inaad ah awoodda ay u leeyihiin in ay xannibi receptors β-adrenergic iyo joogsada in channels potassium. Daawooyinka loo kordhiyo muddada ay la karsado iyo muddooyinka atria reflex iyo intraventricular. Kordhi midab ah ee muruqyada siman bronki iyo lakabka muruqa derbiyada markabka ka. Iska yaree contractility myocardial.

hydrochloride Sotalol leedahay oo dhan guryaha. Miyuu a chronotropic negative, dromotropic, batmotroponoe iyo saamaynta inotropic daroogada Jarmal "Sotageksal". Analogs, oo sideeda oo ka mid ah taas oo ah isku mid, waxaa laga yaabaa in magaca kale. Waxay kaloo ay awoodaan si loo yareeyo xaddiga garaaca wadnaha oo iyagu xooggooda. Sababtoo ah baahida loo qabo this isticmaalka oxygen myocardial waxa aad u yaraynaya. Oo sidii natiijo, load ku on qalbigiisa waa la dhimay.

Nuugista iyo Digo daroogada

nuugista Drug waa deg deg ah. Its bioavailability waa 90%, iyo nuugista - oo ku saabsan 80%. 2.5-4 saacadood oo fiirsashada ugu badan ee firfircoon gudahood waxaa lagu gaarayaa ka dib markii la helo plasma ah. Ka dib markii maamulka xididka, saamaynta ay horey u Muuqda 5-10 daqiiqo ka dib. Nuugista dhacdaa at 20% fiican iyo si dhakhso ah haddii aad qaadato daawada calool madhan. Sababo la xaqiiqada ah in milmi walax ee dufanka uu yahay mid aad u hooseeya, hydrochloride sotalol waa in aan la isku soo qaaday la waxyaabaha caanaha iyo dufanka ah ee asal ahaan xayawaanka.

Isagoo aan la xidhxidhan u borotiinka dhiigga, daroogada waxaa ku qaybiyey unugyada iyo xubnaha durugsan siman 3-4 maalmood ee gelitaanka joogto ah gudahood. Isla mar ahaantaana, iyo waxay gaari saamayn togan ku hypertension. In cerebrospinal fiirsashada daroogada ma aha in ka badan 20%. Action ka dib markii la isku duro sii ilaa 2 saacadood. saamaynta sii socoto ka dib markii kacmaha afka kaniiniyada "Sotageksal" 12 saacadood. Analogs daroogada ee ka kooban taas oo ka kooban hydrochloride sotalol, sidoo kale ma u nugul shiid by kelyaha iyo raaca kaadida (90%) iyo saxaradu ku celcelis ahaan 10-20 saacadood gudahood.

Taasi waa sababta dadka qaba nidaamka kelyaha iyo kaadi mareenka oo yaraada muujinaysaa daawada qiyaasta ka yar. dadka waaweyn waxaa inta badan lagu arkay daraysa da'da la xiriira shaqada kelyaha. Taasina waxay keentaa in xaqiiqda ah in walax la soo bandhigay heerka a gaabis ah iyo isku uruursadaan laga yaabaa in ee jirka ku jira. Sidaa darteed, kooxdan oo ah bukaan daroogada loo isticmaalo si taxadir leh iyo qiyaasta waxaa si gaar ah goostay.

Daawada ka caawisaa in ay caadi sarrifka ee oxygen ee nudaha ku, meesha caro, welwel, stress iyo arrimo kale oo saamayn ku noqnoqoshada iyo xoojinta of foosha waxyaalaha qalbiga ku jira.

"Sotageksal": tilmaamaha loo isticmaalo

Analogs oo ka mid ah daroogada iyo wakiilka waxaa loo isticmaalaa magaca asalka ah, waayo, garaaca wadnaha astaamaha, waayo, daaweynta ee arrythmia ventricular. Laakiin waxaa jira saamayn kala duwan ee bukaanka qaba cudurka la mid ah. Sidaa darteed, waa in ay doorataa dhakhtarka ka dib markii baaritaan dhamaystiran oo si adag on maragga.

Marar dhif ah wakiilka loo isticmaalo daaweynta bukaanada qaba cudurka psoriasis (psoriasis) ama xanuunku ku diabetes qaba dheef carbohydrate oo yaraada. Iska ilaali magacaabi dadka waxay leeyihiin taariikh xasaasiyadda joogo, waxay ka dhigan tahay "Sotageksal". Analogues waxa ay sidoo kale waa inay awoodaan si loo xakameeyo dareenka jirka ee ku meersan xasaasiyad. Si taxaddar leh u daawo loo isticmaalo in lagu daweeyo bukaanka qaba wadnaha, u nugul Niyadjabka soo noqnoqda. Bukaanka ayaa Wadnaxanuun myocardial infarction, halista arrhythmia afaysto inta lagu guda jiro soo dhaweynta "Sotageksala".

muddo Qiyaasta iyo daaweynta

Ku xiran tahay darnaanta cudurka waxaa ka go'an iyo muddada daawaynta daawada "Sotageksal". Tilmaamaha loogu isticmaalo (analogs laga yaabaa in tilmaamaha kale ee soo dhawaynta ah) ku jira talooyinka soo socda:

• kiniin waxaa liqday oo dhan, ma calalin iyo biyo fara badan;
• Reception waxaa la sameeyaa 1-2 saacadood cuntada ka hor,
• qaato daawada 2-3 jeer maalintii.

daaweynta Early dose maalin walba waa in aan ka badnayn 80 mg (1 kiniin) hypertension iyo tachycardia. Si kastaba ha ahaatee, in maqnaanshaha dose saameyn ku daweyn la doonayo kordhay. Tartiib tartiib, la bareeg ah 2-3 maalmood waxaa la beddelo si 240-320 mg maalintii, laakiin kaliya ee isbitaalka. The ugu waxtarka badan waa korodh ah ee qiyaasta of 80 mg halkii todobaad.

Qiyaasta ugu badan waxaa laga yaabaa in 6 kiniin maalin kasta daawada "Sotageksal". Analogues, qiyaasta kuwaas oo laga yaabaa in sidoo kale la kordhin haddii dhakhtarku u arko in loo baahan yahay, in la si gaar ah loo magacaabay doonaan. Xataa haddii ay jirto halis in nolosha, wadarta guud ee firfircoon waa in aanay ka badan 480 mg maalintii.

Haddii cudurada bukaanka functional kelyaha la joogo, daawada ee la doortay sida shaqo ah ansixin kariyaatiniin. Its u kordhay (ilaa 30 mg / min), qiyaasta waxaa caadi ahaan hoos u dhigay labo ilaa afar jeer.

irbado xididka laba jeer ka dhigay maalin, kala qaybiyaa laba duro dhalada of 2 ml. Xalka ayaa si tartiib ah lagu duraa in ka badan 5-7 daqiiqo. Inta lagu jiro daaweynta, gacanta loo baahan yahay ee cadaadiska dhiigga, garaaca wadnaha, kelyaha iyo nidaamka kaadida, ansixin kariyaatiniin ee serum.

maragga

Funds loogu talagalay daawaynta cudurada soo socda:

• tachycardia, ventricular;
• Wolff - Parkinson - White,
• cardiomyopathy;
• garaaca dhicis ventricular;
• prolapse waalka mitral;
• aamba Paroxysmal wadne-atria ah;
• hypertension (cadaadis dhiig oo sareeya);
• ka hortagga iyo daaweynta Wadnaxanuun myocardial (xaaladaha qaarkood).

In shaqada kelyaha ee daran oo yaraada, dhakhtar waxaa ku waajib ah in ay had iyo goor la socon fiirsashada oo ah walaxda firfircoon ee serum dhiigga iyo si ay ula qabsadaan dose "Sotageksal" daroogada. Analogs of tilmaamo ah ee gelitaanka la mid yihiin. Laakiin, inkastoo this, iyaga u gaar ah oo bedel mid daroogada dadka kale gebi ahaanba la mamnuucay. Tirtiridda ee daaweynta waa in ay dhacaan si degdeg ah, laakiin si tartiib tartiib ah. xarun kadis ah waxay sababi kartaa sii daraysa ee xaalad caafimaad.

sababo

Wakiilka kasta antiarrhythmic had iyo jeer ma ahaan loogu talo galay bukaan, oo ay ku jiraan "Sotageksal". Analogs sababo waa isku mid, iyagu ma waxaa loo isticmaali karaa hoos shuruudaha soo socda:

• diidmo ama idiosyncrasy walax aasaasiga ah ama qayb ah kaabayaal ah,
• tabar xagal sanka,
• hoos u calaamadeysan in garaaca wadnaha (bradycardia);
• geeddi socodka obstructive pulmonary chronic;
• neefta bronki daran;
• renal failure;
• Wadnaxanuun myocardial ba'an;
• daran ama joogtada wadnaha;
• lama filaan ah cardiogenic;
• elongated QT bareeg syndrome ,
• da'da carruurta;
• xasaasiyad, rhinitt xasaasiyad,
• uurka iyo nuujinta,
• cadaadiska hoos u dhacay (hypotension);
• suuxinta guud,
• gangrene,
• cudurka dhuumaha ugu sarreeya;
• horumarinta nooca tachycardia "pirouette" (xaalad waxaa lagu ogaada ayado ku badan yahay dumarka badan ee ragga).

waayo-aragnimo ku filan la daroogada xilliga uurka ma aha. Kaliya "Sotageksal" u magacaabay ku tilmaamo muhiim ah. Dhigooda ah saddexda bilood ee ugu horeeya ayaa sidoo kale khatar ku tahay nolosha uurjiifka, iyo qaadanayeen keeni kara in ilmo iska soo ridid. macluumaadka cilmi baadhista lagu kalsoonaan karo oo ku saabsan gelitaanka daroogada ee haweenka dhali ilmo weli ma laha.

Bilihii la soo dhaafay ee therapy la isa soo taraysa u dhimay waa 2-4 maalmood ka hor dhalmada, haddii qof dumar ah oo ay qaadanayso inta lagu jiro mudada oo dhan ee uurka. Taas waxa loo sameeyaa si loo hubiyo in ilmaha dhasha ah ma lahayn Dulmiga hawlaha neefsashada, bradycardia ama hypotension sabab u ah daroogada "Sotageksal".

Analogues ku salaysan hydrochloride sotalol la joojiyo waa in ay qaataan haddii hooyada dhalinyaro ah waa naas-nuujinta, sida maalkii ay leedahay awood ay ku geli caanaha naaska iyo gaari uruureen sare. Haddii muujinaya daaweynta waa in la sii, naas-nuujinta waa ka fiican si ay u joojiyaan, bedelida isku dar caano-qabsiga sida ay da'da ilmaha.

Dhibaatooyinka ay keento iyo badinta

Waxay yeelan karaan waxyeello ka soo gaartey in wadnaha, hormoonada jidhka, kaadida, neefsashada, dheefshiidka iyo bartamaha habdhiska isticmaalka muddada-dheer ee daroogada "Sotageksal". Analogs keenaan waxyeelo la mid ah. Bukaanka ayaa laga yaabaa in ay la kulmaan:

• neefta oo ku qabata, sii kordhaya weerarada angina, calaamadaha wadnaha, wadnaha xanuun, vasospasm, Raynaud ee syndrome ,
• lalabo, matag, shuban, calool xanuun, gassing xad-dhaaf ah, yaaqyaaqsi, dhaqdhaqaaqa adag mindhicirka, xub-axaleedka qalalan afka;
• walaaca, buuqa, argagaxa disorder, dhalanteed, isuduwidda motor oo yaraada, lumida maqalka, isbeddelo ah niyadda, gariir, daal, madax xanuun, wareer, hurdo la'aan ama, la qabsi taas bedelkeeda, kor u kacay, riyooyin walaaca, murugada,
• conjunctivitis, keratoconjunctivitis, ama isha qalalan syndrome (gaar ahaan bukaanka xirtaan contact lenses joogto ah), barar ah wilka, hoos u dhac ku dhadhanka iyo urta, il xanuun, photophobia, ayaa waxloogu oo yaraada, maqalka,
• hypoglycemia (in dadka qaba sonkorowga);
• bronchospasm, jidiinka dhuunta, tracheitis;
• urtikaria, dermatitis, cuncun maqaarka, erythema, psoriasis, anjioedema, dhidid u korodho,
• depression awoodba lab, xanuun biyo bax, haweenka - hoos libido iyo xanuunada caadada;
• qandho, tabar-dari muruq, gariir, dhiigrooraan ee jirka ah.

Xaaladdan oo ah qiyaasta xad dhaafka dhici karaan:

• xakamaynta hawlaha wadnaha;
• neefta oo ku qabata;
• asystole, suuxid, daciifnimo, dawakhsanaan;
• dhiigrooraan ee jirka,
• Qabqabashada muruqa;
• bradycardia in la soo xiro wadnaha buuxa;
• lama filaan ah wadnaha,
• bronchospasm;
• tachycardia.

Inkastoo astaamaha halis ah sida xad dhaafka ah, dhimashada waa dhif. Marka lagu sumoobo daroogada marka hore u baahan tahay si ay u joojiyaan qaadashada daawada "Sotageksal". Analogs iyo xabbo hydrochloride sotalol si hufan wax soo saarka ka soo mareenka caloosha iyo mindhicirka ka dib markii uu qofku cuno daroogada dhuuqda. Xaaladdan oo ah qiyaasta xad dhaafka daaweynta astaamaha lagu muujiyay. Xaaladaha sumowga halis lavage gastric lagama maarmaan iyo matag, sii wado hawlaha nolosha muhiimka ah ee xubnaha gudaha. Xaddi badan waxaa gebi ahaanba laga saaro by kelyaha. Metabolic hoos sonkorta dhiigga ku dhici kara bukaanka u hoggaansamaan cunto adag ama soo goosanaysa.

Analogs iyo xabbo "Sotageksala"

hydrochloride Sotalol ku jira alaabta soo saaray in Switzerland iyo Germany, magaca ganacsiga "Sotageksal" ah. Analogues oo dhanba waxaa lagu muujiyey iyo daroogooyinka kale la Halabuurka kala duwan, kuwaas oo lagu daro saamayn antiarrhythmic caawin murqo, yareeyo cadaadiska dhiigga iyo in la wanaajiyo hawlaha of atria ah. Kuwaas waxaa ka mid ah:

• "Inderal" "Inderal", "obzidan", "Pranolol" (firfircoon - propranolol) loo isticmaalo daweynta ee ischemia, arrhythmia iyo dhiig-karka.
• "Pumpan" - Wakiilka laysugu ku salaysan qaybaha cuntada.
• "Magnerot" waxaa ku jira orotate magnesium dihydrate waxaa loo isticmaalaa daaweynta arteriosclerosis, xanuunada-shiid la egyahay.
• "Korvitol" (tartrate metoprolol) waa wax ku ool ah waayo jaf.
• "Nebilet" (hydrochloride nebivolol) waxa lagu tilmaamayaa, waayo, hypertension, cudurka ischaemic.
• "Qudesan" (drop) - dheeraadka ah noolaha ku salaysan Q10 coenzymes ka hortagga iyo daaweynta garaaca.
• "Etatsizin" (etatsizin) waxaa laga codsadaa at tachycardia ah;
• "Arrhythmia" "Amiodarone" (hydrochloride amiodarone) waxaa loo isticmaalaa in wadnaha, tachycardia, arrhythmia wadne.
• "Propanorm" (hydrochloride propafenone) waxaa loo isticmaalaa marka ventricular iyo garaaca supraventricular.
• "Neo-Giluritmal" (bitartrate praymaliya) waxa lagu tilmaamayaa waayo garaaca ventricular, tachycardia.
• "Korgard" (nadolol) waxa la ansixiyay oo lagu daweeyo kog, xanuunka dhanjafka.

Russia waxay soo saartaa "Sotalol Canon" iyo "Tenzol" la qayb ka mid ah oo firfircoon sida "Sotageksal". Analogues ee Moldova, Ukraine iyo dalalka deriska ah ee farmashiyaha xumbo daroogada asalka ah. Qiimaha daroogada waxay ku xiran tahay dalka iyo soo saaraha. Daawooyinka Guriga caadiga ah waxay leeyihiin qiimo weyn uga yar dibadda.

Reviews

Waxaa jiray hoos u dhac weyn oo soo noqnoqoshada qabashada inta lagu jiro wadne, haddii si joogto ah loo qaaday "Sotageksal". Analogs dib u eegista bukaanka ma aha sidaas wanaagsan. Waxaa had iyo jeer ma daroogada ka saarayaasha kala duwan la mid yihiin, xitaa haddii ay Halabuurka la mid ah. Qaar badan oo ka Cabsan in saarayaasha damiir tilmaamaya fiirsashada weyn oo firfircoon, halkii kaniini ka badan waxaa dhab ahaan waa. Sababta oo ah daawaynta tani ma keeni karaa natiijada laga filayaa. Reviews of "Sotageksale", by la barbardhigo, more wanaagsan. Wuxuu wax ku ool ah loo isticmaalo daaweynta isku dhafan ee cudurada wadnaha iyo heerar kala duwan.

Xaaladaha intooda badan aysan jirin wax horumar ah oo si tartiib ah ee gobolka guud ee bukaanka waajib ah in daaweyn adag. Daawada waa lagama maarmaan labadaba cupping, iyo ka hortagga. Siidi oo ay dib u eegista ah ee bukaanka qaba cudurka ah "aamba paroxysmal," dawada ka caawisaa in ay sii garaaca wadnaha caadi ah (la siiyaa, haddii si joogto ah u qaatay sida daaweynta dayactirka). Si kastaba ha ahaatee, bukaanka ayaa sheegaya in kuma uu dhicin in kor loo qaado qiyaasta u gaar ah oo aan talo dhakhtar ay sabab u tahay khatarta ah in saameyn khatar ah.

Qaar ka mid ah dib u eegista ma saamayn aad u wanaagsan sumcadda of daroogada. Waxaa la rumeysan yahay in ay la xayaysiiyo oo ma awoodi doonaan in lagu daaweeyo dhiig yari, garaaca microbial, hypokalemia iyo hypomagnesemia. Waxaa la xusay in hydrochloride sotalol magac shisheeye waa ay adag tahay in la helo farmasiyada maxaliga ah. Dadka caadaysteen in ay had iyo jeer isticmaalaan hab ka mid ah ay haysato dhibaato ay afku. Sidaa darteed, ka hor inta aadan bilaabin daawaynta, waxaad hubisaa in ay awoodaan in ay sii wadaan muddo dheer noqon doono.

Waa maxay soo dhaweynta aan la isku dari karaa "Sotageksala"

Intii lagu guda jiray bukaannada daweynta waa la jecel yahay in la siiyo ilaa driving, baaskiil, mooto. Sidoo kale khatar yihiin oo dhan hawlaha u baahan yihiin dareenka iyo psychomotor fiirsashada iyo focus. Marka aad hesho lacag dheeraad ah oo lagu yareeyo cadaadiska badan tahay inuu hypotension. Waa mamnuuc in la isu geeyo "Sotageksal" daawooyin sida:

• insulin, sida horay u kordhisaa-fiirsashada ee dhiigga,
• udhigo iyo Doodeen calcium,
• waxay ka dhigan tahay, waayo, guud ama neefsasho suuxinta;
• MAO;
• iodine-ka kooban walax;
• diuretics;
• wada jir ergot;
• murugada tetracyclic.

waa dawo ma isku maamula la antiarrhythmics ee aan fasalka iyo III. Waxaa sidoo kale ahaan uu ku helo maandooriyaha, daawada dajiyaha iyo xasaasiyadda, jirada dhimirka, coumarin, dabcineyso. Waxay sidoo kale gacan ka habdhiska murugada dhexe xoog. suuxdinta wadajira u keenaysaa in kordhay cadaadiska dhiigga iyo kuwa nudaha unugyada depresses myocardial. Waa mamnuuc in la sameeyo baaritaanka maqaarka ah si loo ogaado noocyada xasaasiyadda. Taasi waxay keeneysaa khatar ah ee anaphylaxis, anjioedema, iyo qabatin.

Drug "Sotageksal" daayay farmasiyada by qoro. daaweyn gaar ah arrhythmia oo keeni kara dhibaato halis ah. Sidaas, ka hor inta aadan qaadan daawada, waa in aad had iyo jeer la tasho dhakhtar.