Desensitizing wakiilada, liiska iyo description

Desensitizing wakiilada (antiallergics, xasaasiyadda) - daroogada in la isticmaalo in lagu daaweeyo xaaladaha xasaasiyad. hab ay garoomada ku tahay sida lagu muujiyay qaab xanibeen receptors H1-histamine ah. Sidaa darteed, xakamaynta ah saamaynta histamine - walax weyn ee dhexdhexaadiye bixisa inta badan muuqaalka kore ee calaamadaha xasaasiyad.

Histamine aqoonsaday ka unugyada xoolaha ee 1907, ee 1936, iyo in, dawooyinka ugu horeysay laga helay oo dhaxalsiiyeen saamaynta walax this. Daraasado badan oo soo jeedinaya in ay tahay iyada oo saamaynta ay ku neefsashada gistaminoretseptory, maqaarka iyo indhaha oo sababa calaamadaha caadiga ah ee xasaasiyadda iyo xasaasiyadda ku xakamayn kartaa falcelin this.

Qoondaynta oo ah wakiilada desensitizing on hab ay of saamaynta on noocyada kala duwan ee xasaasiyad:

• Daawooyinka nooca degdeg ah dareen diidmo oo xasaasiyadeed.

• Daawooyinka diidmo nooca-raagay.

Daawooyinka nooca degdeg ah cadaanyo

1. Wakiilada in la xakameeyo sii daayo dhexdhexaadiyayaal xasaasiyad ka unugyada muruqa siman iyo basophilic, Iscelin arkay ee Cascade cytotoxic ah ee fal-celinta xasaasiyadda :

• lacag β1-Adrenomimeticalkie;

• glucocorticoid;

• myotropic saamaynta maroojiska.

2. xuubka unug xasiliya.

3. blockers unugyada receptor H1-histamine.

4. Desensitizing.

5. The inhibitors nidaamka complement ah.

Wakiilada simaha on diidmo nooca-dib u soo

1. NSAIDs.

2. Glucocorticoid.

3. cytotoxic.

pathogenesis xasaasiyadda

Horumarinta pathogenetic xasaasiyadda kaalin muhiim ah histamine uu ku dhexsameeysmo ka histidine oo lagu shubo basophils (unugyada waaweyn), nudaha connective (oo ay ku jiraan dhiig) platelets, eosinophils, limfosaytis, iyo dheecaanka nafleyda. Histamine ee unugyada wakiil wajiga deaktivnoy weheliso borotiinada iyo polysaccharides. Waxaa la sii daayay ay sabab u tahay gacanta iin farsamo, reactions difaaca, sarkhaansan yihiin waxyaabaha kiimikada iyo dawooyinka. Inactivation dhacdaa via ay histaminase unugyada xuubka. Daarida H1 dhaweeyayaasha waxaa yididiila phospholipids xuub. Maadaama uu falgalka kiimikada, shuruudaha in ay gacan ka mudida galay Ca gacanta, iyo falimihiisii dambe on foosha muruqa siman.

Ku-simaha histamine H2 gistaminoretseptory keenaysaa in cyclase adenylate firfircoon oo kordhay wax soo saarka xerada gacanta, waxa sababa la kordhiyo dheecaan ee xabka gastric. Sayidka, wakiilada desensitizing qaar waxaa loo isticmaalaa in lagu yareeyo dheecaanka ee HCL.

Histamine saarta gaddoonka kordhin bixisaa permeability Faahfaahin derbiyada vascular, jawaab edematous, yaraynta mugga plasma, taas oo horseedaysa dhagid hoos u cadaadiska dhiigga ee xididdada, bronki lakabka foosha muruqa siman sabab u ah cuncun gistaminoretseptorov H1; xoojinta sii daayo adrenaline, garaaca wadnaha oo degdeg ah.

Ku-simaha on receptors H1 derbiyada gaddoonka endothelial ah, histamine oo soo bandhigtay prostacyclin, waxaa kor u ansixin, oo weelasha yar (gaar ahaan venules) Escrow dhexdeeda dhiig, da'a in wareegaya mugga dhiigga, taasi waxay xaqiijineysaa in la sii daayo plasma, borotiinada iyo unugyada dhiigga iyada oo derbiyada la dheereeyey mezhendotelialnogo bannaan.

Tan iyo konton konton ah ee qarnigii 20-aad. iyo diyaarinta ilaa haatan desensitizing koreen oo isbedel joogto ah. Qubarada ayaa si ay u abuuraan daroogo cusub oo waxyeelo yar iyo liiska hufnaan dheeraad ah. Marka marxaladdan xaadirka ah, waxaa jira saddex kooxood oo ugu waaweyn daroogooyinka antiallergic: marka hore, jiilka labaad iyo saddexaad.

Desensitizing wakiilada qarnigan ugu horeysay ee

Desensitizing wakiilada jiilka 1-dii si fudud u dhex maro ku kala ooday dhiig-maskaxda (BBB) oo ku xiran yihiin gistaminoretseptorami kiliyaha. desensitizing Tani waxay gacan ka saamaynta ku dejinaysaa, sida qaab yar hurdo ah, iyo qaab of hurdo dhawaaqa. Qarni Medsredstva 1-dii wixii intaa saamayn reaction maskaxda psychomotor. Sababtan awgeed, si ay u isticmaalaan waxaa xadiday in kooxaha kala duwan ee bukaanka.

An dhibic xun oo dheeraad ah ayaa sidoo kale tallaabo tartan la acetylcholine, maxaa yeelay, daawooyinkan la falgala dhammaato dareemayaasha muscarinic sida acetylcholine. Sidaas, marka laga reebo tallaabada nasteexo daroogada waxay keeni afka oo qalala, calool, iyo tachycardia.

Desensitizing jiilka 1-dii si taxadir qoray gulukooma, boogaha, cudurada wadnaha, iyo isku dhafan oo antidiabetic iyo daawooyinka psychotropic. Waa in aanay qaadan in ka badan toban maalmood ah ay sabab u tahay awood u leh inay keeni qabatinka.

wakiilada Desensitizing jiilka 2aad

daawooyinka waxay leeyihiin xidhiidh aad u dheer la receptors histamine ah, iyo hantida ah ee doorashada, sidaas ma simaha on the receptors muscarinic. Intaa waxaa dheer, waxay waxaa lagu gartaa wax lays hooseeyo ee guud ahaan BBB oo aanay ahayn kuwo qabatin leh, ma soo saari suuxintii (mararka qaarkood in qaar ka mid ah bukaanka awood u leh inay si fudud hurdo).

Dhamaadka soo dhaweynta ah ee saamaynta ku daweynta daroogada joogi kartaa muddo 7 maalmood ah.

Qaar ka mid ah hantidaan saamaynta anti-bararka, saamayn cardiotonic. Faa'iida dambe waxay u baahan tahay gacanta nidaamka wadnaha iyo waqtiga ay gelitaanka.

wakiilada Desensitizing saddexaad qarnigan (cusub)

jiil cusub oo daawooyin antisense waxaa lagu gartaa selectivity sare si gistaminoretseptoram. Iyagu ma ay keeni suuxin iyo ma saamayn wadnaha iyo xididada dhiiga.

Isticmaalka daroogada, kuwaas oo laftiisa cadeeyay inta lagu guda jiro therapy antiallergic dheer - daaweynta rhinitt xasaasiyad, rhinoconjunctivitis, urtikaria, dermatitis.

Desensitizing daawooyinka loogu talagalay carruurta

Daawooyinka xasaasiyadda ee carruurta kuwaas oo ka tirsan kooxda H1-blockers, ama dawooyinka antisense - daroogada loogu talagalay daaweynta reactions kala duwan xasaasiyad ee jirka ilmaha. In kooxdan daawooyinka distinguished:

• Waxaan qarnigan.

• II qarnigan.

• III qarnigan.

U diyaar garowga carruurta - qarnigan waan

Maxaa waxaa desensitizing daroogada? Liiska iyaga waxaa lagu soo bandhigay hoos ku qoran:

• "Fenistil" - rekomenovan carruurta waaweyn ka badan hal bil ee foomka of dhibcood.

• "Diphenhydramine" - in ka badan toddoba bilood.

• "Suprastin" - in ka badan hal sano. Ka hor inta uu la magacaabay oo kaliya ee foomka isku duro oo keliya ka yar kormeer caafimaad ee dhakhtar.

• "Fenkarol" - in ka badan saddex sano.

• "Diazolin" - da'doodu ka weyn tahay laba.

• "Clemastine" - in ka badan lix jir, 12 bilood ka dib. ee foomka of sharoobada iyo duro.

• "Tavegil" - in ka badan lix jir, 12 bilood ka dib. ee foomka of sharoobada iyo duro.

U diyaar garowga carruurta - II Generation

The daroogada desensitizing ugu badan ee noocan ah:

• "Zyrtec" - in ka badan lix bilood oo ah qaab dhibic iyo in ka badan lix sano oo kiniin ah.

• "Claritin" - in ka badan laba sano.

• "Aerius" - in ka badan hal sano ee foomka of sharoobada, iyo in ka badan laba iyo toban sannadood qaab kiniin ah.

U diyaar garowga carruurta - III Qarni

wakiilada Desensitizing noocan ah waxaa ka mid ah:

• "Astemizole" - in ka badan laba sano.

• "Terfenadine" - in ka badan saddex sano oo qaab ganaax iyo in ka badan lix sano oo kiniin ah.

Waxaan rajaynaynaa in qodobkan waa in doorashada ee daroogada anti-xasaasiyad jidhka ilmaha (iyo ma aha oo kaliya) si ay u caawiyaan maraan oo sax ah u doorato. Si kastaba ha ahaatee, waxaa la ogaadaa in ka hor inta aan isticmaalka daawooyinka sida waa hubi inaad akhrido tilmaamaha, oo aad su'aal ka qaban karin, "daawooyinka sameeyaa sadha ka - waa maxay?". Sidoo kale waa inaad raadsatid la-talin caafimaad.