Daawo "Cyclophosphamide": tilmaamaha loo isticmaalo, qiimaha, analogs, soo saare iyo dib u eegis

"Cyclophosphamide" waa xarunta ah alkylating. Wakiilka Tani antitumor daroogada. Waxaa la soo saaray sida budada cad ama ku dhawaad sida crystalline. Faahfaahin dheeraad ah oo ku saabsan daroogada this.

"Cyclophosphamide" - saare

Samee daroogada ee shirkadda Ruush JSC "Kiimikada noole." Waxay ku taalaa magaalada Saransk on wadada Vasenko ah, d. 15A.

qiimaha

waxaad ka iibsan kartaa budada №1 «Cyclophosphamide" ee farmashiye kasta. Its qiimaha waa agagaarka 90-98 rubles.

noocyada daroogada

From budada this, xalka waa diyaar. Waxaa loogu tala galay maamulka muruqyada dhexdooda iyo xididka

Features Halabuurka

Halabuurka The of weelka kasta la budada ah waxaa ka mid ah mukhaadaraadka nooca firfircoon loo yaqaan "cyclophosphamide". Qaarkood waa tiro. Kuwaas oo ku jira "Cyclophosphamide" 200 mg ah ayaa sheegay in walax kasta weelka. Tani wax soo saarka, daawooyinka excipients lahayn.

Description of tallaabada pharmacological

Iyada oo ku saleysan tilmaamaha loo isticmaalo, "Cyclophosphamide" - waa alkylating daroogada cytostatic. Its Halabuurka kiimikada ay la mid tahay walxaha sida iniin khardal nitrogen. saamayn pharmacological "cyclophosphamide" waa in ay hirgeliyaan crosslinking nooca transverse dhexeeya DNA iyo RNA qaybood. Sidoo kale diyaarinta this kor u protein Iscelin Avv.

"Cyclophosphamide" - analogues

Xaaladdan oo kale, soo qaado lacag ee ku aaddan category afaraad Ath xeerka. Waxay jeelyihiin in hanti waa "Cyclophosphamide". Analogs daroogada this waxaa jira tiro badan. The ugu caansan waa:

1. "Endoxane".
2. "Ifosfamide".
3. "Alkeran."
4. "Holoxan"
5. "Ribomustin".
6. "Leykeran".

doorashada ee mid kasta oo diyaar u sameeyey by dhakhtarka shakhsiga ku saleysan. Xaaladdan oo kale, waxaa la tixgelinayo qaybaha caafimaadka iyo dulqaad ah.

Xaaladaha qaarkood, a?

Ha ka fikiro si aynu markan si faahfaahsan. Waxay jeelyihiin in hanti waa isticmaalka daroogada noocan oo kale ah sida "Cyclophosphamide". Tilmaamaha loogu isticmaalo arrintan la xiriira waa qalab lagama maarmaan ah. Wuxuu sidoo kale dhigayaa in daroogada ayaa lagu muujiyay xaaladaha soo socda:

1. Haddii aad isku aragto leukemia lymphocytic dabadheer iyo tan ba'an.
2. In joogitaanka myeloma.
3. Haddii calaamadaha of lymphoma non-Hodgkin.
4. Haddii ay dhacdo in fungoides mycosis iyo retinoblastoma.
5. In jiritaanka cudurka Hodgkin iyo kansarka ugxansiduhu iyo naasaha.
6. Marka muujinta calaamadaha neuroblastoma.

Waxaas oo dhan waxay ka sokow, daroogada waxaa loo isticmaalaa in lagu daro daroogada kale wakiilada antitumor lagu daaweyn jiray oo ka mid ah shuruudaha soo socda:

1. Marka burooyinka cell jeermiga.
2. kansarka kaadiheysta iyo sambabada.
3. Sarkooma nooc unug jilicsan.
4. Haddii ay dhacdo in prostate iyo kansarka ilmo galeenka.
5. Marka sarcoma Ewing ee.
6. In the case of burooyinka Wilms '.
7. Marka retikulosarkome.

Sidoo kale diyaarinta sida "Cyclophosphamide", jawaabaha oo fiican, waa wax ku ool ah sida nooc ah wakiilka jirka la muujin horusocod ah, shalalka. Xaaladdan oo kale waxay ka dhigan tahay muuqaalka kore ee arthritis psoriatic iyo rheumatoid, anemia hemolytic, shalalka, collagen, nephrotic syndrome. Sidoo kale ayaa sheegay in hab lagu cabudhibayo reaction diidmada jab.

sababo

"Cyclophosphamide" ayaa sababo gaar ah. Ma loo isticmaali karaa:

1. Inta lagu jiro muddada naasnuujinta iyo uurka.
2. In xadgudub wayn ee function dhuuxa lafaha.
3. Haddii calaamadaha diidmo.
4. Marka la kaadinayo dib u dhac.
5. In jiritaanka cudurada firfircoon.
6. Inta lagu guda jiro muujinta cystitis.

digniin waa lagama maarmaan "Cyclophosphamide", analogues ah kuwaas oo kor ku xusan, maamulo xaaladaha qaarkood. Magac ahaan, iyadoo ay wada joogaan oo ka mid ah cudurada soo socda:

1. Nefrourolitiaza.
2. cudurka wadnaha daran, beerka iyo kelyaha.
3. Turqo.
4. dhexgalka buro unugyada dhuuxa lafaha.
5. Adrenalectomy.
6. Xakamaynta ee function dhuuxa lafaha.

Description of waxyeelo

"Cyclophosphamide", micne ah (analogues) kuwaas oo kor ku qeexan, waxaa laga yaabaa in ay gacan ka ah ee dhibaatooyinka soo socda:

1. nidaamka dheefshiidka muujin kara calaamado sida matag, yalaalugo, anorexia, raaxo, stomatitis, xanuun caloosha aagga, shuban ama calool. Sidoo kale loo yaqaan waa kiisas shaqsi ah cagaarshow iyo ulcerös dhiigbaxa.
2. In daliilka nidaamka hematopoietic ayaa lagu arkay neutropenia, dhiig yari, Torombositobiiniya, leukopenia. Maalinta 7-14 dhaweynta wax yar hoos u dhici doono tirada platelets iyo leukocytes.
3. On daliilka dubka alopecia arkay. mar kale Grow timaha ka dib markii dhamaystiran daroogada. Waxaa intaa dheer, inta lagu guda jiro daawaynta waxaa laga yaabaa in ay dhacaan on finan maqaarka. Waxaa sidoo kale laga yaabaa in joogitaanka midabka jirka ka mid ah isbedel maqaarka iyo cidiyaha.
4. In nidaamka wadnaha iyo markii ay maamusho qaadasho sare ee daroogada muddo waqti dheer waxaa laga yaabaa muujin ka timid cardiotoxicity. Waxaa muhiim ah in la xusuusto. Intaa waxaa dheer, waxaan arkay ah ee xaaladaha adag, iyo mararka qaarkood dhimasho, wadnaha oo istaagay. Tan waxa u sabab dhacdo ee nooca dhiigbaxa myocarditis.
5. In mareenka kaadida waxay keeni kartaa galleeyda oo ka mid ah channels kelyaha (oo ay ku jiraan dhimasho), cystitis dhiigbaxa ama urethritis, cystic kaadida kaadi heysta. Marar dhif ah, codsiga ah ee qaadashada sare ee daroogada dhici kara nephropathy, hyperuricemia iyo shaqada kelyaha. Joogitaanka ah unugyada kaadida laga yaabaa inuu dhaco.
6. In qaabka neefsashada laga yaabaa muujin ka timid fibrosis pulmonary interstitial.
7. The cudurada habka taranka dhici karaan oogenesis iyo spermatogenesis, iyo dhalaysnimo. calaamad Last xaaladaha qaarkood waxaa laga yaabaa karin. Inta badan haweenka ee codsiga of wakiilka arkay horumarinta amenorrhea. daaweynta ka dib, joogta ah ee caadada caadiga ah soo kabanayo. Ragga qaadashada daroogada waxay keeni kartaa in soo bixitaanka of oligospermia ama azoospermia, iyo sidoo kale heerarka atrophy Testicular kala duwan.
8. Xaaladdan oo kale oo laga dheehan karo oo dareen diidmo oo xasaasiyadeed. Taasi waa muujin of a finan maqaarka, cuncun, finan, ficil-celintan jirka.
9. Sidoo kale haddii ay taasi waxaa laga yaabaa inay dhacdo ee waxyeellooyin. Ie dhiig maqaarka wajiga ah, guduudasho, burooyinka sare malignant, dhidid xad-dhaaf ah, madax xanuun.

noocyada dhexgalka

Marka la helo daroogada this, xubno ka mid ah in ay gacan lagu qayilo microsomal beerka, hirgeliyaan hannaanka laaluusheen-shiid microsomal of cyclophosphamide. Tani waxay keenaysaa in arrimo gaar ah. Magac ahaan, si ay formation weyn alikiliruyuschego metabolites nooca. Tani waxa ay yaraynaysaa muddada kaas oo ah nus-nolosha ee cyclophosphamide waa la fuliyay, iyo sidoo kale kordhisaa dhaqdhaqaaqa. Cyclophosphamide, taas oo sicad sii dheeraaday oo uu hakiyo dhaqdhaqaaqa cholinesterase, xoojineysaa tallaabada of suxamethonium. waxay kaloo ka caawisaa si ay u yareeyaan ama hoos-shiid ee cocaine. Sidaas darteed, xooggan ama kor u kacay muddo ah ay saamayn iyo kordhiyaa halista ah ee waxyeello sun. Tani waxay leedahay saameyn xun ku shaqeeyo oo dhan. Intaa waxaa dheer, codsiga isku mar ah allopurinol laga yaabaa in ay gacan ka waxyeello sun on dhuuxa lafaha.

Marka co-maamula la allopurinol cyclophosphamide, colchicine, probenecid, sulfinpyrazone laga yaabaa in u baahan tahay qaadasho saxo protivopodagricakih nooca daawooyinka lagu daaweeyo turqo iyo hyperuricemia. Sidoo kale, marka kororkan muujin kara khatarta nephropathy oo la xidhiidha wax soo saarka kor u of acid uric isticmaalaya cyclophosphamide.

walax dambe waxay keeni kartaa in la kordhiyo hawlaha xinjirowga. Tan iyo Avv this beerka hoos arrimo kor u qaadida xinjirowga dhiigga iyo wax soo saarka dhiig xinjirowga sameeya si daciif ah. Si kastaba ha ahaatee, waxaa sidoo kale laga yaabaa inuu dhaco dhaqdhaqaaqa xinjirowga hoos u dhex ah nooca hab aan la aqoon.

Cyclophosphamide wanaajisaa cardiotoxicity ee daunorubicin iyo doxorubicin. wakiilada jirka kale (chlorambucil, azathioprine, takrolimus, corticosteroids, mercaptopurine, iwm) kordhin kartaa caabuq gala sare iyo burooyin.

Isticmaalka isku mar ah lovastatin in bukaanka qaba wadne kordhin kartaa halista cudurada sida rhabdomyolysis iyo kelyaha ba'an.

Haddii lagu daro daroogada this waxaa loo isticmaalaa daroogada myelosuppressive ama daaweynta shucaaca, waxaa suurtagal ah Iscelin daro muujinta function dhuuxa lafaha.

Maamulka wadajira ee cytarabine at qiyaasood sare leh qalab sida cyclophosphamide, marxalad diyaarinta ah in geeddi-socodka dhuuxa lafta keenaysaa in cardiomyopathy la sii kordhaya bilawga inta jeer dhimashada.

Shuruudaha ugu muhiimsan ee

In codsiga Xisaabiye ee soo socda:

1. Inta lagu guda jiro daawaynta la daroogada this waa in si joogto ah u fuliyaan baaritaan dhiig si loo qiimeeyo heerka uu myelosuppression. Waxaa si gaar ah loo baahan yahay in ay bixiyaan ay tirada platelets iyo neutrophils dareenka.
2. Waxa kale oo si joogto ah waa in aad samayn doona baaritaanka tijaabada kaadida ah jiritaanka unugyada dhiigga cas. Joogitaankooda laga yaabaa in qayb-qaato horumarinta ee cudurada sida cystitis dhiigbaxa. Marka la ogaado daaweynta calaamadaha sida la "Cyclophosphamide", qiimaha kaas oo la kor ku xusan, waa in aad joojiso.
3. Sida tirada platelets (in ka yar 100,000 / ml) iyo / ama unugyada cad dhiigga (<2500 / L) oo ka mid ah hab la helo waa in la joojiyay.
4. Marka cudurka ku dhacaa muddada daaweynta daroogada, ayaa sheegay in daawaynta waa in la joojiyo ama kala gooyey. Ama haddii la helo qiyaasta waa in la dhimay. Ragga iyo dumarka inta ay socoto daawaynta, "cyclophosphamide" Waa lagama maarmaan in la isticmaalo habab lagu kalsoonaan karo ee ka hortagga uurka.
5. Inta lagu guda jiro daawaynta la daroogada this u baahan tahay inaad ka fogaataan khamriga.
6. In kiiska halkaas oo elapse toban maalmood ee ugu horreeya qaliinka, uu wax ka sameeyay hoos suuxinta guud, iyo bukaan-socodka lagu soo qoray "Cyclophosphamide", qiimaha kaas oo la kor ku xusan ka dib, waa in aad soo sheegto shubtaa suuxiyaha.
7. Bukaanka ka dib markii uu qabtay adrenalectomy, waxaa lagama maarmaan ah si ay u fuliyaan haysta sixitaanka qiyaasta ah sida corticosteroids, taas waxaa loo isticmaalaa habka daaweynta bedelka, iyo daroogada noocan oo kale ah, sida daaweynta, "Cyclophosphamide".

taxadarka loo baahdo

Reception ee daroogada ayaa suuragal ah keliya iyada oo ay kormeerayaan dhakhtar kuwaas oo uu leeyahay waayo-aragnimo in chemotherapy. Waxaa sidoo kale waa in ay waafaqsan adag la taliskii qiyaasta. Tani waa in la sameeyaa gaar ahaan therapy isku dhafan. Sidoo kale, uma baahna in ay qaataan labanlaabay xiga ee dose haddii mid ka mid hore uga maqnaan. In diyaarinta daroogada this si loogu isticmaalo dhallaanka laguma talinayo in la isticmaalo diluents kuwaas oo ka kooban khamriga benzyl. Tan iyo markii ay tani keeni kartaa horumarinta dilaa syndrome sun. Magac ahaan, si ay u muuqaalka kore ee aysiidh dheefshiidka, murugada habdhiska, neefta, kelyaha, hypotension, qalal, hemorrhage intracranial.

Inta lagu guda jiray oo dhan ee daaweynta waxaa lagu talinayaa si ay u fuliyaan in dhiig lagu shubo (1 time toddobaadkii 100-125 ml). Tani waa in la sameeyaa ujeedada ka hortagga cudurada sida hyperuricemia iyo nephropathy, taas oo ay sabab u formation of xaddi kordhay of uric acid. calaamadahan inta badan ka dhacaan bilowga muddada daawaynta. Sidoo kale, ka hor sheegay in daaweynta daroogada iyo inta lagu jiro 72 saacadood ka dib markii maamulka waxaa lagu talinayaa in ay sameeyaan a cabbaan gaar ah (qiyaastii 3 litir maalintii), isticmaalka allopurinol (xaaladaha gaarka ah), iyo hab sameeyey kaadida xumadoodu. Waayo, ka hortagga daliilka cystitis dhiigbaxa inta badan waxaa lagama maarmaan ah si ay u fuliyaan faaruqinta kaadihaysta iyo in ay qaataan "UROMITEKSAN". Haddii ay jiraan calaamadaha hore ee cudurka, daawo ayaa sheegay in diyaarinta waa in la joojiyay ilaa tirtiridda dhamaystiran oo wax astaamo ah.

Si ufududeeyaan nooca ifafaale dyspeptic qaadan kartaa cyclophosphamide maalintii ugu horraysay ee qaadasho yar gudahood. Buuxi ama qayb ahaan alopecia, kaas oo laga yaabaa inuu dhaco inta lagu jiro daaweynta waa karo iyo ka dib Dabcan waa la dhimay shaqada koritaanka caadiga ah ee timaha. Si kastaba ha ahaatee, ay midabka iyo qaab dhismeedka laga yaabaa in la beddelo.

Haddii aad isku aragto qarqaryo, qandho, qufac ama xabeeb, xanuun aagga dhabarka hoose, ama kooxda, kaadida oo xanuun ama adag tahay, dhiig ama dhiig, saxaro madow, dhiig saxarada ama kaadida waa in isla markiiba la tasho dhakhtar.

Suurtagalnimada ee Torombositobiiniya, taasoo keentay in baahida loo qabo daryeel gaar ah inta lagu guda jiro hawlaha sida nidaamka invasive iyo nidaamka ilkaha. Waa in si joogto ah kormeeri maqaarka iyo xuubabka oo goobta xididka. Tani waa si loo ogaado calaamadaha dhiig. Waxa kale oo lagama maarmaan ah in la xaddido inta jeer ee venipuncture iyo diidi duridda. Waxaa lagama maarmaan ah in la xakameeyo content dhiig saxarada, mataga, kaadida. bukaanadaan si taxadar leh u daran waa in oofin habka xiirashada, lugaha, dentifrices, findhicil, iwm Goobaha Isla mar ahaantaana waa in si adag loo fogaadaa inuu dhaco iyo dhaawacyo kale. Acetylsalicylic acid iyo khamriga waxaa sidoo kale mamnuucay in ay kordhiyaan halista dhiig-bax caloosha iyo mindhicirka. Xaaladdan oo kale waxaa lagama maarmaan ah si ay u hirgeliyaan jadwalka talaalka dib u dhac ah (ka dib markii 3-12 bilood ka dib markii koorsada dhamaystirka la soo dhaafay chemotherapy). Waa suurad wacan in ay ka fogaadaan xiriir la bukaan faafa. Inta lagu guda jiro daawaynta waxaa lagama maarmaan ah si aad u dalbato ka hortag ku filan.

Markaad la xiriirayso sheegay daroogada la xabka ama maqaarka waa in si fiican biyo saafi qayb ama saabuun ku maydhin, siday u kala horreeyaan.

Naas-nuujinta iyo uurka

Waxaa jira xad hanti arrintan la xiriira, taas oo uu leeyahay "Cyclophosphamide". Buugga muujinaysaa in ahaan uu u yahay isticmaalka daroogada this inta lagu guda jiro uurka. Xaaladdan oo kale, category ee saamaynta on caloosha ku muujinaysaa «D» by FDA. Inta lagu guda jiro daawaynta waxaa lagama maarmaan ah in la joojiyo naas-nuujinta.

badinta

Xaaladdan oo kale, waxaa jira Gudigga qaarkood. Joogitaanka daawo gaar ah la badinta ah ayaa sheegay in samaynta lama garanayo. Waxaa xaqiiqo ah oo lagu kalsoonaan karo. In codsiga xad dhaafka ah waa in loo fuliyo tallaabooyin taageeraya oo ay ku jiraan daaweynta ku haboon cudurrada faafa, iyo sidoo kale dhacdooyinka of wadnaha iyo / ama myelosuppression.

xaaladaha kaydinta

Marka tan la eego, waxay u baahan tahay xaaladaha qaarkood diyaarinta sida "Cyclophosphamide". Tilmaamaha loogu isticmaalo dhigayaa in waa in lagu kaydiyaa heerkulka aan ka badnayn 10 ° C meel in uu yahay mid qalalan iyo in laga ilaaliyo iftiin. In this carruurta ay helaan waxa ay u tahay in la xadiday.

nolosha shelf

Waxaa jira muddo waqti go'an inta lagu guda jiro kuwaas oo daroogada noocan oo kale ah waxaa loo isticmaali karaa sida "Cyclophosphamide". Tilmaamaha loogu isticmaalo muujinaysaa in ay nolosha shaqada waa 3 sano. Xaaladdan oo kale, waa in aad u hoggaansamaan shuruudaha qaarkood. Waa been in xaqiiqda ah in gebi ahaanba la mamnuucay isticmaalka daroogada this ka dib markii muddo this dhacayo.

fulinta

In jihada this, waxaa sidoo kale waa xaalad in uu yahay "Cyclophosphamide". Tilmaamaha on codsiga muujinaysaa in daawada la sii daayo kaliya farmasiyada by qoro.

gunaanad

In text this, waxaa jira macluumaad badan oo faa'iido leh. Oo kaliya waa waxa a "Cyclophosphamide", tilmaamaha loo isticmaalo, qiimaha daroogada this. Si kastaba ha ahaatee, waa in mid ka mid ah ku haay maanka in ka hor inta codsanaya daroogada waa in la dhakhtar aqoon u leh la tasho.