Daawada "Mikosist": dib u eegista, analogues, qiimaha. Drug "Mikosist": tilmaamaha loo isticmaalo

Drug "Mikosist" diiwaanka qeexayaa sida wakiilka ah antifungal. Walaxda firfircoon oo ka mid ah falalka fluconazole daroogada - inhibitor xulashada of Avv sterol in unugyada fangas. Waxaa lagu cabudhibayo nidaamka aadanaha cytochrome P450 ma muujiyaan waxqabad androgenic, waa wax ku ool ah oo la tixgelinayo wareer ah ee mycosis.

Pharmacokinetics

Ka dib markii medicament afka ama xididka "Mikosist" (user muujinaysaa this) si fiican u galay dareeraha jidhka iyo unugyada. In xaako, dheecaanka xuubka hoose iyo articular, candhuufta, caanaha naaska fiirsashada daroogada oo la mid ah in gaari ee plasma dhiigga. content ee fluconazole in dheecaanka lafdhabarka in bukaanka qaba fangas meningitis waa siddeetan boqolkiiba fiirsashada ee plasma oo, ee jeedo, waa si toos ah saamiyeed si ay qiyaasta. Marka codsiga mar-maalmeedka in maalintii afraad-shanaad oo 90 boqolkiiba waxaa lagu gaarayaa fiirsashada hoganaya. Haddii maalinta ugu horeysa ee la qaadanayo qiyaasta ah in ka badan caadiga ah laba jeer, waxaad heli kartaa maalintii labaad si ay u gaaraan 90 boqolkiiba raasamaal hoganaya ah. Kow iyo toban ilaa laba iyo toban boqolkiiba xidho fluconazole borotiinka plasma. yihiin metabolites dhiig durugsan lama dareemo. Pharmacokinetics ku xiran tahay muhiimad on kelyaha, sababta oo ah daroogo la raaca inta badan iyaga bandhigayaa, iyo siddeetan boqolkiiba - beddelin. saddex saacadood oo dialysis gudahood fiirsashada oo ah walaxda firfircoon ee plasma waa la dhimay by badh.

Tilmaamayaasha waayo,

Waxaa lagu talinayaa in la isticmaalo daroogada "Mikosist" cabeebka, oo ay ku jiraan guud, faafiyay, taranka, marka noocyo kale oo cudurka faafin Candida, candidemia, oo ay goobjoog ka ahaayeen arrimo ay sahla ah ee cabeebka. Sidoo kale muujiyay waa isticmaalka daroogada ee dadka qaba candidiasis xuubka: dalqada, candidiasis afka ay ka mid yihiin Atrophic, ka timi xiran la gashado; hunguriga. Daawo "Mikosist" diiwaanka ku talinaysaa in ay maamusho si ay bukaanka ka cabanaya cryptococcal meningitis, ama sepsis, cryptococcosis, cudurka cryptococcal maqaarka ama sambabada. Waxa uu sidoo kale codsatay hortagga xoogeystay ka mid ah kuwan aan caadi ahayn in dadka qaba AIDS iyo xaaladaha kale ee jirka. Daawooyinka loo isticmaalo si looga hortago cudurada fangas in dadka qaba burooyinka halista ah, u nugul iyada oo sababtu tahay shucaac ama chemotherapy in laga adkaado xogta. Sidoo kale, daroogada "Mikosist" waxaa loo isticmaalaa in lagu daaweeyo cudurada boqoshaa gumaarka iyo jir, mycoses-gud u qoto dheer, oo ay ku jiraan paracoccidioidomycosis, coccidioidomycosis, histoplasmosis in bukaanka qaba qaabka difaaca jirka ee caadiga ah.

Foomka qiyaasta, baakadaha, halabuurka

Laba nooc qiyaasta of medicament leeyahay "Mikosist": kaabsoosha oo xal loogu talagalay galiyey. Kaabsoosha ka samaysan yihiin oo ay ku jiraan 50, 100 iyo 150 milligram ee fluconazole. Dhamaan iyaga ka mid ah waa gelatin adag, la jirka ah mudane Doolaal ku cad, oo ku kala duwan yihiin oo kaliya in dabool color: kaabsoosha y ku jiraan 50 miligaraam oo ah qayb firfircoon, iftiinka cap buluug 100 milligram - sumurud, 150 milligram - buluug. Content waa a mass adag budada ah ama cad (ku dhowaad caddaan) budo. maaddooyinka siyaada dhaqmaan milmahayn magnesium, ammooniya lactose, Silicon Kolloidol dioxide, Rusheyn kartaa, titanium dioxide, galleyda, gelatin, Carmine indigo. Kaabsoosha oo ay ku jiraan 50 iyo 100 mg ah fluconazole, waxaa suuq in baakadaha la mid, laba, afar finan, toddoba xabbadood kasta. Iyo kuwa ay ku jiraan 150 milligram ee firfircoon - in hal ama laba xabbadood.

xal galiyey ayaa qaab dareere ah oo hufan, midab ama khafiif ah midab. Mid ka mid ah ku jira laba milligram per mililitir oo ah walaxda firfircoon. Qaybaha sare waa biyo la isku duro iyo chloride sodium. xal siiyey in galaas fijaan boqol millilitir meeleeyay kartoonno. Mid ka mid ah khariidadda ku jira mid ka mid ah ku shubtay.

Sida loo qaato "Mikosist"? qiyaasta

Qiyaasta caadiga ah ee fluconazole in cudurka cryptococcal waa maalinta ugu horeysa ee daaweynta, 400 mg, wakhtigii socda - 200-400 milligram. Muddada daaweynta waxay ku xiran tahay xaqiijiyey daraasad mycological ee waxtarka caafimaad, waa inta badan wax ka badan lix - siddeed toddobaad. In cryptococcal meningitis isticmaali daawo "Mikosist" tilmaamaha loo isticmaalo talinayaa in toban - iyo toban toddobaad ka dib natiijada ahaa baarka waxbarasho xun ee cerebrospinal. bukaan AIDS ka dib marka daaweeyntu kuu dhammaato bilawga ah waxaa lagu tilmaamay ka hortagga ah ee ku xoogeystay of cryptococcal meningitis muddo dheer soo dhaweynta ka dhigan tahay "Mikosist" at dose ah oo aan ka yarayn laba boqol oo milligram per maalintii.

In bukaanka qaba candidiasis faafiyay, candidemia iyo cudurrada kale ee invasive Candida, inta badan maalinta ugu horreysa ee ay afar miligaraam oo ah daroogada, iyo in maalmaha soo socda - laba boqol oo milligram maalin kasta. In case of dose daran khamiir systemic lagu kordhin karaa ilaa sideed boqol oo milligram per maalintii. Daaweynta waa in la sii ugu yaraan laba toddobaad ka dib markii tirtiridda calaamadaha iyo helitaanka dhaqan dhiig xun. Haddii candidiasis cunaha, oo ay ku jiraan in bukaanka qaba difaaca oo yaraada, qiyaasta daawada maalin kasta waa konton - boqol iyo milligram, qaadashada inuu noqdo muddo toddoba - afar iyo toban maalmood. In candidosis Atrophic keentay ka xiran la gashado sida caadiga qoray qaato maalin konton miligaraam oo ah daroogada isku dhafan oo aalkolada. Daaweynta sii waday muddo laba toddobaad ah. Waayo, cudurrada kale ee Candida (candiduria, esophagitis, maqaarka iyo candidiasis xuubka) dose maalin kasta daawada waa konton - boqol iyo milligram, therapy waa afar iyo toban - intii soddon maalmood ah.

Si aad u baabi'iyo medicament candidiasis siilka "Mikosist" qaab diiwaanka ay qaataan waallayn qadarkuu of 150 milligram. Waxay noqon kartaa afar - laba iyo toban bilood bishiiba mar ah oo aan cabbo hal kaabsal (150 mg) si loo yareeyo inta jeer ee soo noqoshada. Inta badan loogu candidiasis lagu daro daroogada "Mikosist" shumaca, tusaale ahaan, "Terzhinan", "Clione-D", "Ginezol". Iyadoo ku xiran xaddiga khatarta cudurka fangas, ka hortagga ah ee candidiasis dose maalin walba lagu talinayo ee daroogada ku kala duwanaan kara konton ilaa afar boqol oo milligram.

In the case of mycoses-gud u qoto dheer u baahan karaan in ay qaataan daawada ee qiyaasta ah laba boqol - afar boqol oo milligram per maalintii muddo laba sano ah. Muddada aad daawada ku xiran tahay qofka shakhsiga ah iyo sawirka clinical: la coccidioidomycosis, waxaa u dhaxayn karo kow iyo afar iyo labaatan bilood, paracoccidioidomycosis - laba ilaa toddoba iyo toban bilood, histoplasmosis - saddex ilaa toddoba iyo toban bilood.

xeerarka codsiga

diyaarinta faleebo xididka waa in la maamulo heer ah in aan ka badnayn labaatan millilitir halkii daqiiqo. Ma jirto baahi loo qabo in la beddelo qiyaasta maalin kasta marka wareejinta bukaanka ka xididka daawada afka laga qaato. Xalka for galiyey jaanqaadi dvadtsatiprotsentnym xal glucose, xal Hartman oo Ringer; xal of carbonate sodium hydrogen, chloride potassium in glucose ah, chloride sodium (0.9%). Faleebo lagu qaban karaa iyadoo la isticmaalayo xirmooyinka fluconazole caadiga ah ee lagu shubo, iyadoo la isticmaalayo mid ka mid ah xalka soo socda.

waxyeellooyin

Inta badan bukaanka qaatay daroogada "dib u eegista Mikosist 'oo ku saabsan waxa ay ka dhigeysa wanaagsan. Drug dhab wax ku ool ah ay meesha caabuq fangas laakiin waxay sababi kartaa waxyeello ka soo gaartey. Sidaas daraaddeed, nidaamka dheefshiidka waa khatarta ah lallabo, yaaqyaaqsi, beerka aan caadi ahayn, dhibaatooyin la xiriira dareenka dhadhanka, shuban. Sidoo kale, qaar ka mid ah dadka tixraac dhacdo ee madax xanuun, suuxitaan, wareer. Waxay sheegeen in ay ifafaale sida waajibo wax yar ka dib qaadashada daroogada, "Mikosist". Reviews bukaanada kale ee ku jira macluumaad ku saabsan horumarinta xasaasiyadda therapy daroogada ee foomka of erythema, finan, anjioedema, urtikaria. Ka mid ah waxyeelooyin kale oo suurtagal ah in la xuso alopecia, aamba ventricular, shaqada kelyaha oo yaraada, hypertriglyceridemia, hypercholesterolemia, iyo hypokalemia.

sababo

In foomka of kaabsoosha waa in aan lagu soo qoray daawo in carruurta ka yar lix bilood jir (ee dhallaanka loo ogol yahay in ay isticmaalaan daroogada ee foomka of xal faleebo). Ha isticmaalin daawada this "Mikosist" dumarka nuujinaya (haweenka uurka leh waxay u baahan yihiin in ay ku wareejinayso daryeelka), iyo sidoo kale dadka qaba dareen sare si ay Cuntadan waxaa ka mid ahaa in ka kooban. Iyada oo baahida loo qabo in kor u kacay in ay isticmaalaan taxadar in bukaanka qaba la'aan kelyaha / cagaarshowga, dulqaad of acetylsalicylic acid.

badinta

"Mikosist" diiwaangelisay kiisas muujinaya badinta daroogada. Reviews dadka qaatay daroogada ee xaddi badan, ayaa tilmaamaya horumarka shuban, lallabo, matag. Xaaladaha daran, waxaa jira muuqaalka kore ee qalal, dhaqanka khayaano, dhalanteed. Qofka qaba calaamadaha xad dhaafka ah waa in loo qaaday isbitaalka, halkaas oo lavage gastric lagu sameyn doonaa isaga, dialysis, diuresis qasbay, therapy astaamaha.

"Mikosist" ama "fluconazole", taas oo ka wanaagsan?

Haddaba su'aashu waxay is weydiiyo by bukaanka. Dhab ahaantii, labada daroogada waa isku mid, waxaan dhihi karaa in ay yihiin isku mid ah. Faraqa kaliya ee waa in daawada "Mikosist" dhigaysa shirkadda Hungarian dawooyinka "Gidcoon Richter", halka "fluconazole" - diyaarinta soo saarka gudaha. Dabcan, tani waxay leedahay saameyn toos ah ku kharashka daawooyinka. Doorashada waxa ay u soo iibsadaan - "Mikosist" ama "fluconazole" - badan door bidaan in ay daroogada, taas oo ka jaban. Indeed, farqiga weyn ee qiimaha. Sidaas daraaddeed, Waayo, baakada of "Mikosista" (mid ka mid kaabsal oo ka kooban 150 milligram ee fluconazole) inaad bixiso celcelis ahaan 295 rubles, halka xirmo isku "fluconazole" qiimaha keliya 8-20 rubles. celceliska qiimaha ee dhalada 100 ml oo ah xal loogu talagalay galiyey "Mikosist" waa 311 rubles.

Marka la eegayo hantida pharmacological oo ka mid ah laba daawooyin, waxay shiidaa isku mid yihiin, farqiga loo arki karaa marka laga reebo in heerka of nuugista: sida ay macluumaadka la heli karo, midda ugu badan ee jirka ku jira "fluconazole" waxaa gaadhin 1-2 saacadood ka dib markii codsi ka dib, iyo "Mikosista" - 0.5 -1,5 saacadood. Si kastaba ha ahaatee, ma bukaan oo dhan ka jawaabo labada daawooyinka si siman. Qaar ka mid ah ma aragno wax faraqa u dhaxeeya, halka ay aaminsan yihiin in tayada ay ku xiran tahay qiimaha, taas oo macnaheedu yahay in daroogadu waa ka qaalisan, ayaa u roon. inta badan waxaad ka heli kartaa dib u eegista, taas oo haweenka ku andacoodaan in ka dib markii ay "fluconazole" cabeebka ayay dib u noqdeen, laakiin "Mikosist" oggol yahay in laga takhaluso waxaa ka mid ah si joogto ah. Si kastaba ha ahaatee, doorashada adigaa leh.

analogs

Waxa intaa dheer in "fluconazole", waxaa jira daawooyin kale oo badali karto daroogada "Mikosist". Analogs medicament isagoo qayb sida firfircoon walax la mid ah, waxaa sidoo kale wakiil. In foomka of kaabsoosha lagu daaweyn jiray khamiirka iyo cudurrada kale ee fangas, waxaad isticmaali kartaa daawooyinka "Diflucan" "Flucostat", "mikomaks" iyo kuwa kale. hab wax ku ool ah waa "Mikoflyukan" (kiniin). "Mikosist" ka, kuwaas oo dhan analogs kala duwan by tilmaamayaasha sida bioavailability, bar-nolosha, heerka of nuugista.

isdhexgalka daroogada

Waa lagama maarmaan in si taxadar leh loola socdo ee waqtiga prothrombin in bukaanlayda qaadato fluconazole oo ay la socdaan xinjirowga lidka dadban group coumarin, maxaa yeelay, waxaa jira halis ah oo sii kordhaya VWP ah. Marka concomitantly la sulfonylureas daroogada "Mikosist" cimrigiinnu ku badhkiis nolosha iyaga ka mid ah, si aad u baahan tahay si ay u eegaan suurtogalnimada ah hypoglycemia. In the case of fluconazole iyo qaybsiga phenytoin laga yaabaa degree Caafimaad ahaan la taaban karo ee u siyaadiyaa fiirsashada ee la soo dhaafay, sidaas daraaddeed, haddii ay muhiim tahay marka la isku daro helo qiyaasta waa in la dhimay. Wada jir ah ula gelitaanka macnihiisu yahay "Mikosist" iyo rifampicin waxaa la qorayaa mid hoos u dhac ku fiirsashada of fluconazole sidaas daraaddeed qiyaasta "Mikosista" loo baahan yahay in la kordhiyo. Isticmaalka isku derivative ah azole la medicament a isku dhafan oo terenadinom ahaan uu u, sida horumarin karaan daran, arrhythmia naf-gooyada ah. Haddii aad u qaadato dawada "Mikosist" si wadajir ah ula cisapride, muujin karaan dareen diidmo oo aan loo baahnayn on qayb ka mid ah waxyaalaha qalbiga ku jira, oo ay ku jiraan tachycardia ventricular. Iyadoo la isticmaalayo isku mar ah fluconazole iyo theophylline hoos heerka ansixin celcelis ahaan ka plasma dhiigga ee la soo dhaafay, oo sidaas daraaddeed waxay kordhisaa suurtagalnimada of horumarinta ee saamaynta ay sun iyo badinta.

ganaaxyada

Waa in ay sii wadaan daaweyn "Mikosist" ilaa dembidhaafka caafimaad iyo hematological. joojiyo dhicis ah ee daaweynta waa ben la soo noqoshada. Sida hore u soo sheegnay, bukaanka qaba la'aan kelyaha waa in ay isticmaalaan daroogada si taxadir leh ugu badnaan, maxaa yeelay, waxaa raaca inta badan by kelyaha. Qiyaasta inta lagu jiro daaweynta mudada dheer waa in la sameeyaa, iyada oo la tixgelinayo CC ah. Mararka qaarkood fluconazole ku lug leedahay waxyeello sun beerka ku dul yaal, sidaas awgeed waa lagama maarmaan si ay ula socdaan hawlaha jidhka this. Marka la ogaado calaamadaha lesions waa in ay joojiyaan daawada.

Bukaan-socodka ku saabsan asalka ah "Mikosist" waxa laga wadaa ahayd aragtida dhif ah cadaanyo cutaneous exfoliative, sida necrolysis epidermal sun iyo Stevens-Johnson syndrome. Bukaanka qaba neoplasms malignant iyo AIDS waa ka badan u nugul ah ee reactions maqaarka daran marka la isticmaalayo diyaarinta ka kooban fluconazole. Haddii inta lagu guda jiro daawaynta cudurka fangas maqaar saar finan ka muuqataa, daroogada aad rabto in aad joojisid. Haddii aad isku aragto finan in dadka qaba cudurka fangas invasive ama systemic dhakhtarka waa in la xoojiyo kormeerka iyo ka qaato daroogada ay dhacdo in la horumariyo doonaa multiforme erythema, ama lesions bullous. Inta lagu jiro daaweynta, daawo "Mikosist" (dib u eegista ay u xaqiijin) waxay keeni kartaa wareer, sidaas darteed bukaanka u baahan tahay in si gaar ah taxaddar marka la farsamo iyo maareynta gaadiidka ka shaqeeya.