Antimicrobial TSifran. Isticmaalka daroogada

Daawo "TSifran" waa wakiilka antimicrobial leh qaybaha kala duwan ee ficil iyo iska leh kooxda pharmacological of fluoroquinolones. qaybaha firfircoon ee daroogada waa ciprofloxacin iyo tinidazole. Sababo la xiriira xakamaynta of gyrase DNA iyo bakteeriyada Iscelin Avv DNA, kuwaas Walxaha firfircooni waa aadka u firfircoon ugu sheyga garaam-negative.

Gaar ahaan, hawl ficilka bactericidal of diyaarinta "TSifran" qoraalo diiwaanka marka la eego, kuwaas oo bakteeriyada: Neisseriagonorrhoeae, Neisseriameningitidis, Haemophilusinfluenzae, Pseudomonasaeruginosa, Salmonellaspp, Escherichiacoli iyo muruq sheyga kale soo saara oo aan soo saarin penicillinase, iyo sidoo kale noocyo Methicillin u adkaysta iyo Enterococcusspp, Chlamydiaspp, Mycobacteriumspp, Legionellaspp ... nooc.

tallaabo pharmacological of spectrum tilmaamaha bactericidal medicament ballaadhan "TSifran" si loogu isticmaalo waa sida soo socota: ". aalad waxaa loogu tala galay daaweynta heley faafa wax ku ool ah ee daaweynta ee geedi socodka bararka - cudurada isku qasan xanaajiyeen by waxqabad ee sheyga laylinta iyo anaerobic iyo protozoa".

Pharmacokinetics

The sinji daroogada "TSifran" tilmaamaha loo isticmaalo waxaa loola jeedaa aadka u socon. Oo ciprofloxacin iyo tinidazole leeyihiin nuugista wanaagsan ee mareenka caloosha iyo mindhicirka.

Ka fiirsaneysa kasta oo ka mid ah maaddooyinka firfircoon ee daroogada, waxaa in la xuso in ciprofloxacin uu leeyahay oo ku saabsan 70% bioavailability. Its nuugista waa xoogaa Kobocii, halka isticmaalka cuntada. daroogada waxa uu leeyahay permeability wanaagsan galay unugyo iyo dheecaannada jidhka, oo ay ku jiraan lafaha, muruqyada, baruurta, iyo unugyada carjawda. Waxa uu guskiisa galay xubnaha nidaamka kaadida, oo ay ku jiraan sida prostate ee jidhka ah. Waxa ay ahayd mid sir ah u waxyooday kiprofloksatsina content-fiirsashada sare ah, sida, runtii, iyo in shahwada, candhuufta, bile, dareeraha qanjirada, xab.

Tinidazole bioavailability buuxda kala duwan. qayb Tani waxay sidoo kale si degdeg ah dhaco uruureen sare ee unugyada jirka dadka ku irbadu dhexdhexaad ah ee dareeraha ah, gaar ahaan in cerebrospinal, kaas oo ku howlan sidii heerka plasma ee isku. About rubuc ka mid ah xaddiga walxaha daama raaca kaadida iska beddelin, oo ku saabsan 10% la sii daayay oo ah qaab metabolites, qayb ilaa xad yar oo qayb jirka ka baxo in saxarada ah.

Tilmaamayaasha for daroogada tilmaamaha "TSifran" loo isticmaalo waxaa loola jeedaa in daaweynta isku dhafan ee geedi socodka faafa. Waxaa ka mid ah heley gaar ah, oo lagu daweeyo daroogada hoos tixgelin taas oo loo isticmaalayo, cudurada soo socda:

• osteomyelitis chronic ;

• geeddi socodka bararka intra-faafa,

• dabadhiig qaba amoebic iyo dabadhiig qaba nooca isku dhafan (amoebic bakteeriyo);

• periodontitis, periostitis iyo cudurada kale ee faafa ee saabka afka laga qaato;

• cudurada bararka dumarka;

• hogaga chronic;

• cudurada maqaarka iyo unugyada jilicsan,

• cudurada faafa postoperative;

• malax sambabada.

Mid ka mid ah iyaga ka mid ah, iyo cudurada kale ee ay keento bakteeriyada laylinta iyo anaerobic xasaasi ah in ay tallaabo ka mid ah qaybaha daroogada.

diyaarinta la ajiibay "TSifran" postprandial. Kiniiniyada waa in la qaato biyo tiro ku filan. bukaanka Adult qaadashada daroogada laba jeer maalintii loox oo ka mid ah 500 / 600mg ama laba 250 / 300mg. Bukaan-socodka da'doodu ka yar tahay siddeed iyo toban sano jir, daroogada aan la maamulo. Waxaa laguma talinayo in loo isticmaalo uurka.

Sababo isticmaalka daroogada tilmaamay in therapy waa dareenka sii kordhaya in qaybaha ay qayb ka mid ah tsifran iyo cudurada dhiig, porfyri oo la xirrira.