ACTH (hormone a) - waa maxay? ACTH

shaqada ee jidhka ku salaysan yahay is dhexgalka ee dhammaan qaybaha ay dastuurka - unugyada iyo xubnaha. Si kastaba ha ahaatee, xakameeya weyn ee hawlaha ay yihiin walxaha runta ah ee qaab-dhismeedka kala duwan. qaababka waxaa ka mid ah hormoonada. Mid ka mid ah walxaha waa adrenocorticotropic muhiimka ah (ama ACTH) hormone.

ACTH (hormone a) - maxay tahay

walax waxaa soo saaray qanjirka pituitary ee - qanjirka hormoonada jidhka ugu weyn ee ka mas'uul ah fulinta gebi ahaanba hawlaha oo dhan. Waayo, wax soo saarka ee ACTH kulmi unugyada eosinophilic of pituitary ee jilibka.

Tarjumay magaca Laatiin ah hoormoonka macno u muuqataa sidii "xiriira in qanjidhada adrenal." Gudbinayeen socodka dhiigga iyaga, walax bilaabo hawlgalka qanjidhada, kuwaas oo, kaas oo kor u horumarinta wakiilada adrenal gaar ah. hab ay of tallaabo hormoonnada qanjidhada, kuwaas waxaa loogu talagalay hawshooda oo dhan hababka shiidaa ilaaliya in si firfircoon uga muuqato hoos stress.

keligeed, ACTH waa Britain protein ah. Its qaab-dhismeedka waa arrin adag, waxa ay leedahay qaybo badan, kuwaasoo mid walba uu u qabata shaqo gaar ah (la xidhiidha receptors gaar ah, xasilloon shaqo ee xubnaha, ayaa mas'uul ka ah saamaynta immunogenic).

Maandooriyaha Adeeca a kirkeydiyanka, ie waqti ay fiirsashada badan waqtiyada kale ee weyn.

biosynthesis

Sida ACTH ku dhexsameeysmo jirka (hormone a)? Waa maxay, waa ay adag tahay in la fahmo, tan iyo Britain oo isku xubno ka borotiinada (acids amino) iyo koox hydroxyl (-OH), iyo sifooyin of amines biogenic (-NH2). Tan iyo markii ugu of Britain waa silsilad ku harta amino acid in conventionally waxaa loo arkaa in ay peptide ama protein.

walaxda uu ku dhexsameeysmo ka ee loo yaqaan protein maamaan ah. Saldhig ahaan ereygu wuxuu ahaa ee pro-opiomelanocortin falalka Britain hormone.

hormone Adrenocorticotropic, sidii hore u soo sheegnay, waxaa la soo saaray ee la xidhiidha laxanka kirkeydiyanka, ie waqtiga maalinta. , Ereygu waxa uu sidoo kale ku xidhan tahay hormone - corticotropin (laga bilaabo hormone hypothalamic mas'uul ka keenaysay pituitary ee). Corticotropin si firfircoon uga soo saaray laga bilaabo 6 subaxnimo ilaa 9 am, iyo tirada yar ee ay lagu arkay dhiig u dhexeeya 19 iyo 23 saacadood. Iyadoo taas ku xiran, iyo variruetsya qadarka ACTH ee dhiigga.

Doorka hoormoonka

Sida ku xusan, hormone adrenocorticotropic ayaa mas'uul ka ah hawlaha oo ka mid ah qanjidhada adrenal. Helitaanka gelin dhiiga, hoormoonka kiciya ama wax soo saarka ee glucocorticoids - yaqaano Cortisol, cortisone iyo adrenokortikosterona. hormoonnada Kuwan waxaa si firfircoon uu jidhku u isticmaalo in uu ku dardar kuwa ama unugyada kale iyo qanjiro. hab tallaabo hormone ku salaysan yahay ay ku qabanaya in receptors adrenergic gaar ah oo ku yaalla unugyo badan, iyo xididdada dhiigga. Sida kor looga hadlay, hormoonnada kuwani waa "stress", i.e. la kordhiyo waxqabadka ee u shaqeeyo in joogitaanka halista ah iyadoo ay sabab u pathogene kasta.

hormoonnada waxay leeyihiin saamayn firfircoon anti-bararka, samaynta taagayo ay dardaro loo isticmaalay dawo.

Intaas waxaa sii dheer, oo u dhexeeya ACTH iyo hormoonnada adrenal leedahay xiriir gaar ah: walax kordhiyaa-fiirsashada ee hormoonnada adrenal iyo xad-dhaaf ah u keenaysaa in xaqiiqda ah in uu joojiyo soo saara ACTH (hormone). Waa maxay for ifafaale ah, iyo sababta ay tani ka dhacaya - weli lama yaqaan, laakiin isku liddiga ah laftiisa waxaa loo yaqaan "-celinta".

Muhiimadda caafimaad ee

ACTH wuxuu kobciyaa waxqabad ee adrenal. Haddii aan hormoonkan, qanjidhada noqon doono firfircoonayn, taasoo keeni lahayd in ay cudurro kala duwan.

Si kastaba ha ahaatee, waxa uu mararka qaar ka dhaca iyo in xaddiga ACTH in dhiig kala duwan yihiin, iyo qeexidda waa lagama maarmaan. Hormone ACTH, heerka of taas oo dhiigga ku noqon doonaa siman yahay si ka 9 ilaa 46 halbeeg (bogga / ml) ayaa muujinaya hawlaha caadiga ah oo sax ah functional of pituitary ee. Inta ay hormone la Qolol karaa ama hoos u dhac (sida caadiga ah - la'aanta ah waadaxa ah waxaa ka mid ah in dhiigga).

Si loo go'aamiyo heerka peptide adeegsaday imtixaanka ACTH ah.

Waxaa sida caadiga ah waa la fuliyay in xaaladood oo looga shakisan yahay joogitaanka cudurka. dadka Healthy daraasad this aan la tusay.

Siidi by heerka hoormoonka ee fiirsashada dhiigga, ku tirinnaa in, on wixii la hoos waa habka bahal - at heerka of dhidibka hypothalamic-pituitary ee ay sabab u tahay xidhiidh kasta oo u dhexeeya heerka qanjidhada adrenal iyo qanjirka pituitary ee.

Determination of heerarka hormone dhiig

Sida hore u soo sheegnay, si loo ogaado fiirsashada of hormone lagama maarmaanka u ah ACTH - imtixaanka. Habkani wuxuu kuu ogolaanayaa inaad si loo ogaado in hormone this ee dhiigga.

Habeeynimadii of daraasadda waxaa lagu talinayaa in aadan samayn jimicsi culus, iyo sidoo kale in ay ka fogaadaan khamriga iyo maandooriyayaasha kale psychotropic. Ma talinayaa in cuntooyinka ba'an iyo sigaar cabbin. 3 saacadood ka hor daraasadda waa mamnuuc in sigaar.

Dhiigga waxaa caadi ahaan la macaamilooday calool madhan subaxdii (oo keliya haddii ay jiraan no endocrinologist xeer khaas ah). Xaaladaha qaarkood (shakiyay cudurka Cushing ee), hormone ku bartay fiidkii.

Waayo, cilmi dhiigga arooriyaha ah ee bukaanka. Waa in la go'aamiyo by hormoonka adrenocorticotropic.

ACTH (heerka) ka dib natiijada waxaa la barbar qiimaha tixraaca (hormone caadiga ah ku jira ka 9 si ay u 46 bogga / ml). weecasho kasta waxaa caadi ahaan loo arko caadi ahayn.

Sababta u ah heerarka of ACTH sii kordhaya

Waa kuwee cudurada kordhay ACTH? Kuwani geedi socodka bahal ah waxaa ka mid ah:

• Cudurka Addison ee (cudur naxaas ah, yaridu adrenal hoose). heerka ACTH baxdo ay sabab u tahay xaqiiqada ah in aan soo saaro hormoon oo qanjidhada adrenal.
• kelyaha lagu dhasho.
• cudurka Cushing ee (xaddiga hormone kordhay sababo la uruureen bahal ee CRH).
• Syndrome ee wax soo saarka ACTH ectopic (cudur la xiriira horumarinta unugyada pituitary masuul ka ah wax soo saarka ee ACTH meel atypical).
• Nelson ee syndrome.
• syndrome Paraneoplastic (burada).
• Xaaladaha la xidhiidha qalliinka ama dhaawacyada.
• Virilism qanjidhada adrenal.
• Maamulka daawooyinka si toos ah (hormones si toos ah pituitary) ama si dadban (by saameeya hypothalamus oo lagu cabudhinayo qanjidhada adrenal) nidaaminaya qanjirka pituitary ee.
• stress daran ama xaalad aad u daran.

heerarka hormone Dhimay

Under waxa xaaladaha ACTH hoos?

• kaafi adrenal Sare. hoos u dhac ACTH ahaa ay sabab u tahay xaqiiqada ah in hormoonnada adrenal waxaa horumariyo qadar xad-dhaafka ah oo waaweyn, si kastaba ha ahaatee, ma ay sheegi karin ee ay u shaqeeyaan.
• buro adrenal (Cushing ee syndrome). formation Tani waxay kordhinaysaa tirada unugyada hormone-soo saarka, iyadoo ay sabab u keenaysaa in heerka sii kordhaya ee adrenal Avv hormoonnada ACTH iyo is-celin.
• Isticmaalka kriptogeptadina. daroogada waxaa loogu talagalay xakamaynayaan xarunta gaajo ku yaalla hypothalamus ah. Sidaas darteed, tani waa la baabi'iyay karaan iyo liberinov Avv.
• neoplasms Kortizolprodutsiruyuschie. Waxbaa ka duwan burada la Cushing ee syndrome, laakiin saamaynta waa isku mid.
• Isticmaalka daroogada glucocorticoid in qaadasho sare. Jidka Silk yaraynaysaa wax soo saarka dabiiciga ah ee hormoonnada adrenal, laakiin ay sabab u tahay uruureen badan oo talooyin istaago saara ACTH.

Daaweynta bukaanka qaba heerarka hormone beddeli

Sidee dawayn karaa bukaanka haddii uu kordhay hormone adrenocorticotropic?

ACTH (a hormone) la kaantarooli karaa by therapy daroogada, soo-gaadhista iyo isticmaalka hababka qalliinka.

therapy Medical waxaa ka mid ah isticmaalka nudaha (marka loo isticmaalo sida midhaha canabka oo la hoos heerarka hormone). Inta badan, waxay ku waxaa loo isticmaalaa in xaqiijinaya jiritaanka kansarka. Waxaa ugu ballaaran loo isticmaalo "Hloditan", "Mercaptopurine".

Dawaynta ilayska waxaa loo isticmaalaa meesha uu formation buro degaanka ee maskaxda. Codso gamma-therapy ama saameyn proton.

qalliin loo xilsaaray in ay dhacdo failure of daaweyn muxaafidka ah (daawooyinka iyo cindiga). qanjirka adrenal waxaa inta badan laga saaray, waxaana ku xiga chemotherapy degdeg ah. burooyinka maskaxda ka ayaa sidoo kale laga saaro, si kastaba ha ahaatee, waxqabadka waa wax adag, sidaa daraadeed waxa la fuliyay qabsiyada.

Dhibaatooyinka la xiriira isbeddel ah ee heerarka hormone

Waxaa inta badan u dhacdaa in heerka dheeraad ah ama hoos u of ACTH keeni kara dhibaatooyin kala duwan.

dhibaatada adrenal - xaaladda ugu badan ee keenta in xaqiiqda ah in kor u ACTH (hormone a). Waa maxay?

dhibaatada adrenal waxa lagu gartaa heerka aan caadi ahayn sare ee hormoonnada adrenal in teedu tachycardia, cadaadis kordhay. Against asalka this, inta badan waxay yeeshaan wadne iyo stroke. Intaa waxaa dheer, dhibaatada keeni karta in ay yaraadan ee jirka, taas oo ah mid aad u khatar ah oo keeni kartaa dhimasho.

Qaadista heerka ACTH inta badan keenta in horumar kaafi adrenal, roonaadaan soo noqnoqda ee suuxid ama burburkii. Intaas waxaa sii dheer, qayb ahaan jebiyey iyo shaqada galmada (sida qanjidhada adrenal soo saaro xaddi yar oo ah testosterone oo estrogen).

Si hufan si looga hortago horumarinta cuduradaan, waxaa lagu talinayaa in hab wakhti in la xaddido heerka hormoonnada.