"Boudin" neefsasho: tilmaamaha loo isticmaalo, sharaxaad, halabuurka iyo dib u eegis

In daaweynta neefta bronki la agonist beta-blockers hubkaas ayaa loo isticmaalaa corticosteroids neefsado in la yareeyo inta jeer iyo adkaanta dhacdooyin of bronchospasm. Ka mid ah kooxdan oo ah daroogada waa in la siiyo "Boudin" for neefsasho. on codsiga ee buuga "Budenita" waxaa ku jira macluumaad faahfaahsan oo ku saabsan isticmaalka daroogada, si aan u bixiyo tixgelinta mid ah qaababka ugu muhiimsan iyo Gudigga farsamada ee codsiga dareenka inta lagu guda jiro therapy nebuliser.

Qaab dhismeedka macnaheedu yahay "Boudin steri-neb" (ganaax)

Waxbarashada waxay muujinaysaa in daroogada waa ganaax ah neefsasho, wax garad midab iyo ur, buuxiyey oo galay fijaan polyetylen of 2 ml, oo ka kooban 1 mg (0.5 mg / ml) ama 0.5 mg (0,25 mg / ml) budesonide qayb firfircoon. Qalabkan waxaa la xidhiidhaa kooxda pharmacological hormoonnada glucocorticoid codsiga la mariyo.

pharmacodynamics

Sida caddayn daroogada "Boudin" edbinta ee la neefsado, budesonide (qayb weyn ee firfircoon) ayaa anti-xasaasiyad, anti-bararka iyo anti-bararka saamayn. By madadaalo protein lipocortin budesonide saarka saamayn inhibitory on Avv phospholipase, taas oo keenta in hoos u dhac in ereygu acid arachidonic, hoos u wax soo saarka ee prostaglandins iyo leukotrienes. Nidaamkan waa mid heer gacanta keenaysaa in la yareeyo wax soo saarka cytokine, yareeyo socdaalka ee macrophages oo u wadin inuu hoos u dhac ku dhex dhuuntaan gacanta. Ugu dambayntii waxay keenaysaa in hoos u heer oo dhexdhexaadiyayaal bararka in si wanaagsan ay ka tarjumaysaa on yareeya neefta bronki iyo xasilinta ay dabcan kiliinikada.

Sida caddayn daroogada "Boudin steri-NEB 'tilmaamaha loo isticmaalo, in ay isticmaalka joogtada ah u keenaysaa in dib u soo celinta dareen geedka bronki daroogada, weynaadaa bronkie. Tani waxa ay noqonaysaa yaraynaysaa badnaanta isku isticmaalka dambeeyay, yaraynaysaa qadarka ahbaa dheecaan bronki xaako, yaraynaysaa dareen in xasaasiyadda, kaas oo sidoo kale waxay leedahay saamayn togan ku Dabcan caafimaad ee cudurka.

Daawada ma laha hawlaha mineralocorticoid, iyo waxyeelo ma laha systemic ay sabab u tahay tallaabo maxaliga ah, taas oo hoos u soo noqnoqoshada iyo adkaanta waxyeelo si fiican loo dulqaatay in loo isticmaalo daba dheeraaday.

Sida medicament ee "Boudin steri-neb" diiwaanka, analogs daroogada iyo waxaa si fiican loo dulqaatay oo ma keenaan dhacdo waxyeellooyinka la xidhiidha isticmaalaya corticosteroids systemic.

Ka dib markii codsi hal ka mid ah saamaynta ay ku daweyn yeesho in dhowr saacadood, oo gaarey qowlka ugu badan ka dib markii 1-2 toddobaad kadib markii bilowga isticmaalka. Daawada lagu ool ah loo isticmaali karaa ka hortaga cudurka neefta bronki stress jirka, laakiin ay sabab u ah muddo dheer oo hurda, Bilowgii hore ee tallaabo-daweynta ficil ahaan ma ku haboon yahay gargaarka ee xaaladaha ba'an ku lug bronchospasm.

Pharmacokinetics

Daawada waxaa maamula la isticmaalayo mashiinka a. Marka neefsado ceeryaamo wanaagsan budesonide degtaa on dusha sare ee geedka bronki. About 15% ka mid ah daroogada ay sabab u tahay nuugista in Lumen bronki galo wareegga systemic oo dheeraad ah metabolized iyadoo la isticmaalayo nidaamka cytochrome in metabolites shiidaa firfircoonayn (ay hawl ilaa 100 jeer ka yar hawl mid ah waxyaabaha la bilaabo). About 70% ka mid ah daroogada saxarrada kelyaha by yahay, iyo 10% waxaa raaca dhex mindhicirka.

Tilmaamayaasha

Sida budesonide daroogada aasaasiga ah iyo analogues ay ku muujisan yihiin ee daaweynta iyo ka hortaga cudurka neefta, waxtardarradoodu ee isticmaalaya agonist beta-adrenergic doortaan hortagga cudurka iyo xasilinta ee sawirka clinical, iyo sidoo kale si loo yareeyo qaadasho ku daweyn of wakiilada glucocorticoid afka. Daawada ayaa la isticmaalay si guul leh lagu daaweyn jiray laryngotracheitis stenotic iyo chronic obstructive pulmonary disease.

sababo

"Boudin steri-neb" (ganaax neefsasho) waa u in joogitaanka dareen diidmo oo xasaasiyadeed ka mid ah ama in ka badan qaybaha ka kooban of daroogada, iyo sidoo kale carruurta da'doodu ka yar tahay 6 sano. Iyada oo daryeel weyn daroogada la qoray qaaxada sambabada, guuldaradii of Respiratory viral, bakteeriyada, fangas microflora, beerka. Diidaya isticmaalka daroogada iyadoo ay wada joogaan ee cudurada faafa uu keeno saamayn jirka deegaanka axaleedka in waxay keeni kartaa in la yareeyo jawaabaha difaaca iyo faafidda cudurka.

waxyeellooyin

Sababo la xaqiiqada ah in daroogada waxaa maamula neefsasho isticmaalaya nebulizer ah, siday suuragal u ah ee dhacdo of qallayl xuubka ee afka iyo sare ee marinada hawada, dareen dhuun xanuun iyo cuncun, dhadhan xun oo aan caadi ahayn, xabeeb ama xabeeb, qufac. Tan waxa u sabab dagitaan daroogada mikrochastichek dushiisa xuubka ah.

Waxay jeelyihiin in dhif arkay cudurada of habka dareemayaasha jirka, taas oo isu muujin qaab isku yaacsanaan oo kordhay excitability ah neuro-nafsi ah, xanuunada dabeecadda, madax xanuun. Intaa waxaa dheer, bukaan oo codsanaya "Boudin" mararka qaarkood waxay keeni dareen diidmo oo xasaasiyadeed xusay sida urtikaria, cuncun ama casaan maqaarka, dabac muruqyada siman bronki, iyo horumarinta candidiasis ee saabka afka iyo hunguriga.

dhacdo ee bronchoconstriction wada socda iyo dyspnea horumar ka dib bilowgii qiyaasta koowaad neefsado ay sabab u tahay diiqayaa tallaabo daroogada on xabka marinka hawada. Iyadoo horumarinta this dhinaca neefsashada saamayn waxaa lagu talinayaa in la joojiyo iyo in uu magacaabo therapy kale.

Inkastoo bioavailability hoose oo ka mid ah daroogada iyo saameynta ay ku badan degaanka, isticmaalka sii dheerayn ku dhici karo saamaynta systemic ee glucocorticoids. Tani waa hawl Iscelin muujiyey of kiliyaha adrenal, gaabis ah koritaanka carruurta, hoos cufnaanta lafaha macdanta, horumarinta xadgudubyada aragtida.

Xaaladaha qaarkood (dhif) waxay keeni kartaa cuncun maqaarka marka la isticmaalayo maaskaro nebulizer. Si looga hortago dhibaato this waa in la isticmaalaa xal lagu nadiifiyo, waayo, maaskaro, iyo ka dib neefsasho ah maqaarka hoostiisa socda biyo diiran. Waxa kale oo aad sii daayo kartaa cinjir xiisad haysta maaskarada wajiga. alternative A wanaagsan u shaqayn kartaa sida isticmaalka afka ama afka for neefsasho.

Isticmaal ee uurka iyo nuujinta

Tilmaamaha on "Boudin" talinaysaa daroogada loo isticmaalo si taxadir leh in haweenka uurka leh iyo inta lagu jiro naas-nuujinta (in kasta oo xogta ku saabsan alaabta galo maqan yahay caanaha hooyada). Daawada waxaa lagu talinayaa in la isticmaalo oo kaliya marka faa'iidooyinka ay hooyada u bi'isaa saamaynta gurracan ee suurogalka ah iyo dhibaatooyinka si ay ilmaha caloosha ku. Sayidka waxaa lagama maarmaan ah in la isticmaalo budesonide ugu yar wax ku ool ah in qiyaas in oggolaanayaa buuxda gacanta cudurka.

isdhexgalka Drug

At heerka xiriirka ka dhexeeya samaynta ioyo jaanqaadi xal isotonic of chloride sodium, iyo sidoo kale kale neefsado beta-agonister, mucolytics iyo expectorants. Si loo kordhiyo waxtarka iyo saamayn-ku-daweynta ee daroogada dabac yareeya bronki kooxahan laga yaabaa in lagu wada meeleeyay qolkii nebulizer. Wadaagista bronchodilators ma aha oo kaliya hagaajinaysaa socodka "budesonide" geedka bronchoalveolar, laakiin sidoo kale kordhinayaan in ay wax lays qoto dheer galay Lumen ah.

Sababta oo ah ka qaybgalka kooxda ensaymes P450 cytochrome ee dheefshiidka ee dose budesonide waa in dib loo eego marka la isticmaalayo daroogada taas oo ku tuuji ama hawl ah eulayska madadaalo. Aan lagula talinayaa isticmaalka daroogada si wadajir ah daawooyin antifungal sida "ketokonazol" iyo "Itraconazole", maadaama ay tani waxay keeni kartaa in la kordhiyo fiirsashada of "budesonide" plasma.

Medicaments oo la kordhiyo waxqabadka ee falgalka microsomal ( "Phenobarbital", "phenytoin", "Rifampicin") loo yareeyo dhaqdhaqaaqa "budesonide".

Qadarka Qaadashada

Pretty fudud si ay u isticmaalaan, "Boudin" for neefsasho. Tilmaamaha loogu isticmaalo waxay muujinayaan baahida loo qabo in la isticmaalo nebulizer ah si loogu soo daweeyo. Daawada waxaa la geeyaa qalab nebuliser ah, iyo neefsanayo. Muddada neefsasho iyo qiyaasta waa in lagu doortay in kiis kasta oo la tixgelinayo xaaladda caafimaad ee bukaan-socodka iyo darnaanta cudurka marka la isticmaalayo daroogada "Boudin" neefsasho ah. Waxbarashada loogu talagalay carruurta 6 bilood illaa 12 sano tilmaamay in magacaabista budesonide laba jeer qiyaasta ka yar. Waayo, bukaanka ka weyn yahay 12 sano, qiyaasta dayactirka waa in si gaar ah beddelo.

Haddii loo baahdo, "Budenita" daro daroogada glucocorticoid afka lagu talinayaa in la kordhiyo qiyaasta of "Budenita" ka hortaga of dhacdo iyo in la yareeyo darnaanta waxyeellooyin.

Reviews

Daweynta dhakhaatiirta iyo bukaanka ku qancay isla oggolyahay ee daroogada. Tani waa caddaynta ku dib u eegis ah oo ka mid (ganaax neefsasho Teva «Boudin" - a daroogada quruxsan oo caan ah) dejinta. Fikirka A wanaagsan sameeyay dhacdooyinka hoose ee waxyeelo iyo daaweyn heer sare ah wax ku ool ah. Opinions ku saabsan "Boudin" dejinta for neefsasho loogu talagalay carruurta (edbinta, qiyaasta la siiyey ee maqaalka) waxay leeyihiin hooyooyinka wanaagsan, kaas oo sidoo kale waxaa sabab u ah dhacdooyinka hoose oo waxyeelo. neefsasho isticmaalaya nebulizers aan xanuun lahayn (oo lagu samayn karaa in noocyo kala duwan oo toys) ee carruurta yaryar sidoo kale ka hadlay ay guushu ku isticmaalka daroogada, ama analogues ay.

badinta

In xad dhaafka ba'an calaamadaha caafimaad oo aad u daran ayaa la arkay. Daaweynta waa astaamaha, la baabiiyo of daroogada iyo magacaabidda-simaha gaaban nooca tallaabo bronchodilator ah.

Waa in la dhasha maskaxda ku haysaa in la isticmaalo daba dheeraaday "Budenita" at qiyaasood oo aad iyo aad u sredneterapevticheskih laga yaabaa in waxyeelo heer systemic (hypercortisolism, niyad-jabka ee function adrenal). Tani waa caddaynta ku "Boudin" edbinta inhalant. Its qiimaha waa la heli karaa si loogu isticmaalo muddada-dheer ee daroogada sida therapy a aasaasiga ah ee neefta bronki.

tilmaam iyo talo gaar ah

Tilmaamaha loogu isticmaalo daroogada "Boudin" ayaa sheegay in aysan waxaa loogu talagalay in laga nafiso weerar ba'an ee bronchospasm. Waqtiga celceliska ah ee saamaynta ku daweynta ee ku saabsan 10 maalmood, laakiin waa la kordhin karaa joogaan in Lumen geedka bronki ama xaddi badan oo dheecaan xab viscous. Xaaladdan oo kale waxa suurto gal ah si ay u qabtaan daaweynta isku dhafan oo glucocorticoid afka kala guurka xiga oo kaliya "Boudin steri-neb" neefsasho.

Tilmaamaha in daroogada ayaa sheegay in, inkastoo jaaniska waxyeellooyinka heerka nidaamka aad uga hooseeya, waxaa lagama maarmaan ah in titrate qiyaasta ugu yar ee wax ku ool ah daweynta saamayn ugu badnaan. In codsanaya daroogada ee carruurta gol leeyahay in aqoonsiga waqtigii of waxyeello ka soo gaartey waa in la joogto ah loola socdo koritaanka ilmaha muddo dheer. Iyadoo horumarinta waxyeellooyin waa in la hoos u qiyaasta ugu yaraan wax ku ool ah, kaas oo u ogolaanaya in la xakameeyo weerarada xiiqda.

Wixii ka hortaga cudurada fangas in saabka afka ee bukaanka waa in la wargeliyo baahida loo qabo in biyo raaci afka iyo ka saari harta ka dib neefsasho kasta. Tani waxay kor u soo celinta difaaca maxalliga ah iyo xabka afka.

Tilmaamo Technical Isticmaal

Neefsasho "Budenita" isticmaalaya nebulizers ultrasonic ahaan uu u. Qiyaasta wax ku ool ah ee daroogada waa in la xisaabiyaa iyada oo la tixgelinayo qaababka farsamo ee gaarka ah ee nebulizer (tixgelinayo heerka socodka hawada, mugga ah nebuliser iyo D. t.) Oo xaaladda bukaanka.

Ka hor inta la isticmaalayo "Boudin" nebulizer daroogada neefsasho ee edbinta nebulizer waa qasab waa in la bartay. Tani waxay iska ilaali doonaan xidhiidhka aan habboonayn ee qalabka iyo isticmaalka hawlqabad la'aan ah daroogada. Haddii nebulizer loo isticmaalo markii ugu horeysay, waxaa lagu talinayaa in aad tijaabiso isticmaalaya xal sodium chloride nafsaaniga ah si loo hubiyo in ay Oxperts Consultants iyo waxaa ka dibna loo isticmaalo daawooyinka.

Ka hor inta neefsasho sanduuqa soo kabsaday ampule caag ah, waxaa la furay laga- dabool, daroogada lagu meeleeyo qolkii nebulizer of qalab ah, gashaday maaskarada wajiga (ama afka demisay) iyo quudin jiray si ay u socodka hawada. Inta lagu guda jiro ku neefsasho oo isticmaalaya afka u baahan tahay in aad neefsato oo keliya afka (gashado sanka clip gaar ah). Marka la isticmaalayo a codsiga maaskaro neefsashada sanka optionally clip.

Waayo, neefsasho waxaa lagu talinayaa in la isticmaalo nebuliser si ay u qalab biiyaha kaas oo bixiya cirbad daroogo buufis wanaagsan si toos ah xilligan ee neefsasho oo xirtey outlet ee daroogada waqtiga uu dhacayo ah. Tani waxay kordhisaa bixinta daroogada ee qori bronchoalveolar iyo yaraynaysaa khasaaraha ka mid ah daawada inta lagu guda jiro katimaada.

"Boudin steri-neb": analogues, qiimaha

analogues Drug "Boudin steri-neb" waa daawooyin sida "Pulmicort" iyo "Pulmicort Turbuhaler", "Kortimen", "Tafen", "Budoster", "Budenofalk" iyo kuwo kale oo badan. At daawooyinka, kuwaas oo, sida diyaarinta "Boudin" neefsasho, edbinta waa isku mid sabab u ah joogitaanka qayb ka mid ah oo firfircoon. kharashka Data daroogooyinka waxay ku xiran tahay shabakadda farmashiyaha iyo gobolka, iyo sidoo kale qiyaasta. Celcelis ahaan, qiimaha u dhaxeysa 650 si 2550 rubles.

gunaanad

medicament aadka wax ku ool ah ee daaweynta iyo ka hortaga cudurka neefta waa "Boudin" neefsasho. Tilmaamaha in daroogada ku siinayaa macluumaad faahfaahsan oo ku saabsan qiyaasta iyo shuruudaha isticmaalka daroogada this. Bixiyo codsiga budesonide iyadoo la raacayo tilmaamaha iyo talinayaa qaadashada of medicament ku bixisaa daaweynta ku ool ah. Haddii sabab uun aadan iibsan kartaa asalka ah, waxaa jira analogues. "Boudin steri-neb" (tilmaamo qiimaha aad hadda loo yaqaan ah) idinka badbaadin doonaa, cuduro badan oo ka mid ah qaabka neefsashada.